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anti-Human Endothelin 1 Antibodies:
anti-Mouse (Murine) Endothelin 1 Antibodies:
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Human Monoclonal Endothelin 1 Primary Antibody for IP, ELISA - ABIN560688
Ghoul, Serova, Astorgues-Xerri, Bieche, Bousquet, Varna, Vidaud, Phillips, Weill, Benhadji, Lokiec, Cvitkovic, Faivre, Raymond: Epithelial-to-mesenchymal transition and resistance to ingenol 3-angelate, a novel protein kinase C modulator, in colon cancer cells. in Cancer research 2009
Show all 3 Pubmed References
Dog (Canine) Monoclonal Endothelin 1 Primary Antibody for ICC, FACS - ABIN152685
Talati, West, Blackwell, Loyd, Meyrick: BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertension. in American journal of physiology. Lung cellular and molecular physiology 2010
Show all 2 Pubmed References
Human Monoclonal Endothelin 1 Primary Antibody for IHC (fro), IRMA - ABIN2473438
Papalambros, Sigala, Georgopoulos, Menekakos, Giatromanolaki, Bastounis, Sivridis: Immunohistochemical expression of metalloproteinases MMP-2 and MMP-9 in abdominal aortic aneurysms: correlation with symptoms and aortic diameter. in International journal of molecular medicine 2003
Study shows that cerebrovascular muscle cells can express endothelin-1 (ET-1). The production of ET-1 in cerebrovascular muscle cells stimulated by oxyhemoglobin occurs partially through the NF-[kappa]B signal pathway.
Plasma ET-1 levels of rabbits increased significantly in fluorinated groups compared with those in the control group.
Dynamic monitoring and comparison of plasma levels of ET, CGRP, NO, and MDA as well as SOD activity revealed that appropriate intervention of these factors may reduce reperfusion injury
In a saline lavage-induced lung injury model, both circulatory and pulmonary ET-1 levels increased.
Data suggest elevated levels of endothelin-1, as exhibited in cardiovascular diseases, facilitate development of ventricular arrhythmia by steepening action potential duration restitution and by increasing beat-to-beat variability of repolarization.
High levels of ET-1 are closely associated with BBB disruption. ET-1 may play an important role in the pathogenesis of secondary brain injury after ICH.
After subarachnoid hemorrhage, the contractile response to ET-1 was enhanced, and the ET(A) receptor expression was upregulated in the basilar artery.
After acute pulmonary thromboembolism, thrombolytic and anti-inflammatory treatment could decrease acute lung injury induced by ET-1 and NF-kappaB activation. [endothelin-1; NFKB]
The increase in myocardial distensibility induced by endothelin-1 is absent in heart failure and is dependent on nitric oxide and prostaglandin release.
Endothelin-1 enhances nuclear Ca2+ transients in atrial myocytes through Ins(1,4,5)P3-dependent Ca2+ release from perinuclear Ca2+ stores
The enhancement of gap junction intercellular communication is activated by endothelin-1 via modulating the expression of connexin43, and plays an important role in the pathogenesis of cerebral vasospasm
In conclusion, endothelial vWF knockdown prevented angiotensin II-induced ET-1 upregulation through attenuation of NOX-mediated O2- production.
sub-vasomotor concentration of ET-1 leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 kinase-mediated production of superoxide from NADPH oxidase following ETA receptor activation
ET1 was lowest in kidneys removed from live pigs, greater in kidneys from pigs with brain death, and greatest in kidneys from pigs with cardiac arrest.
ET-1 contributes to formation of oedema during experimental sepsis by a novel mechanism involving increased HBP release from neutrophils.
Endothelin-1 expression is upregulated following therapeutic hypothermia after cardiac arrest.
Our experiment with isolated porcine ophthalmic ciliary arteries revealed a refractoriness phase to ET after an acute stimulation with ET. This refractoriness was transient and disappeared after 4 h.
ET-1 produces contraction of the urinary bladder neck muscles via muscular ET(A) receptors coupled to extracellular Ca(2+) entry via VOC (L-type) and non-VOC channels.
urinary biomarker to determine kidney graft injury
Endothelin-1 elevation is not only a conserved phenomenon in a pig traumatic brain injury (TBI) model, but it is a likely target for understanding the observed enhanced vascular response to TBI.
interleukin-6, endothelin ET-1, and apoptotic Bak and Bcl-XL genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury
ET-1 elicits a different pattern of Src family kinase (SFK) activation and might trigger a different pattern of SFK activation from that caused by ATP and UTP.
Compared with the untreated group, the levels of serum ET-1 after acute myocardial infarction and reperfusion were significantly decreased in the Xuefu Zhuyu-treated group.
study suggests a possible role for endothelin-1(resulting from the actions of endothelin-converting enzyme-1) acting via endothelin receptor A in the control of luteolytic sensitivity in the pig
vasoconstrictor influence of endogenous as well as exogenous ET on coronary circulation in vivo is reduced in myocardial infarct
Data show the presence of a continuative and differentially regulated stimulating mechanism of ET-1 expression during pig endotoxaemia as well as a fundamental role of ET-1 system in the cardiovascular and respiratory derangement.
These data support a linkage between the proinflammatory cytokine IL-1beta and vascular dysfunction within the intestinal circulation, mediated, at least in part, by the ET system.
extracellular ET-1 regulates the abundance of ET-1 mRNA in PAECs, in an ETB receptor-dependent manner, by modulating both mRNA stability and transcription via mechanisms involving receptor endocytosis and both ERK and p38 MAPK pathways
Cyclosporine-A stimulates angiotensin I/II secretion by kidney glomeruli.
Left ventricular unloading with intra-aortic counter pulsation prior to reperfusion reduces myocardial release of endothelin-1 and decreases infarction size in a porcine ischemia-reperfusion model.
The beneficial effect of carvedilol on myocardial no-reflow could be due to its effect on ET-1 via the activation of the K(ATP) channel.
Increased expression of ET-1 exaggerates diabetes-induced endothelial dysfunction.
Reduction of NO bioavailability and release results from elevated Arg-2, accumulation of intracellular ADMA, and imbalance of ET-1 and ETBR, further leading to IUGR-associated vascular endothelial dysfunction.
The present study demonstrated that the circulating bigET-1 was valuable in the assessment of the severity of CAC.
Unfavorable genotype of polymorphic variant of candidate gene participating in endothelial dysfunction EDN1 (Lys198Asn) was associated with changes in levels of their active substances in individuals exposed to mercury.
Endothelin-1, nitric oxide, and serotonin are related to blood pressure in adolescent males.
this study provides that infants with genotype GT eNOS 894G > T have 3.4-fold higher risk of developing of IVH if they are born before 28 + 6 weeks of gestation.
Preeclamptic plasma stimulates the expression of miRNAs in HUVECs, leading to a decrease in endothelin-1 levels.
According to the results of the present study, the culture solution with HUVECs affected the differentiation ofdental pulp stem cells (DPSCs). In addition, ET1 may promote the odontoblastic differentiation of DPSCs.
EZH2, ET-1, and CD34 may act as biomarkers of aggressive cervical squamous cell carcinoma
The plasma D-dimer and ET-1 levels provided a novel marker for treatment selection for the T-segment elevation acute myocardial infarction patients with a type 2 diabetes mellitus history.
EDN1 rs5370 polymorphism was associated with large artery stroke development.
Endothelin-1 is a regulator of Mena expression in the serous ovarian cancer.Endothelin-1 role in the invadopodian function.
Studied effects of dexamethasone on gene expression regulation of sirtuin 1 (SIRT1), interleukin 6 (IL6), and endothelin 1 (EDN1) in gingival derived aging stem cells. Dexamethasone downregulated expression of SIRT1 and IL6 but upregulated EDN1 in stem cells.
Baseline big ET-1>0.56pmol/L was independently associated with higher all-cause mortality and HFH among CRT recipients.
this study provides the first evidence that a 2-SNP haplotype of the ET-1 gene is associated with increased risk of hormone refractory prostate cancer
During exercise, we noted a rapid and significant reduction in venous ET-1 levels in obese subjects but no significant change in lean subjects.
Serum levels of miR-31 and endothelin-1are elevated in psoriasis vulgaris and are suggested to play significant roles in the pathophysiology of psoriasis.
Plasma big ET-1 level is a valuable independent predictor of ST in patients with coronary stents, especially in the acute coronary syndrome population.
Although our study revealed higher serum ET-1 and lower serum alpha-Klotho levels in systemic sclerosis patients compared to healthy controls, there were not any significant correlations between their serum levels with severity of organ involvement.
plasma EDN1 levels were significantly increased in Korean patients with fibromyalgia syndrome (FMS) compared with those in healthy controls. EDN1 SNP was revealed to be associated with susceptibility to FMS.
Knocking down basolateral amygdala (BLA) ET1 expression enhanced anxiety-like behaviors, whereas over-expressing ETBRs, but not A-type receptors (ETARs), had an anxiolytic effect
Increased ROS, notably H2O2, contributes to enhanced afferent arteriolar responses to ET-1 in diabetes, which is closely associated with Wnt signaling.
Endothelin-1 expression is increased in a model of kidney injury, along with fibroblast expansion.
strial capillary basement membrane thickening results in hypoxic stress further elevating extracellular matrix and ET-1 gene expression, exacerbating strial pathology
TWEAK may stimulate endothelial ET-1 synthesis, through the up-regulation of ECE-1.
c-Src tyrosine kinase mediates high glucose-induced endothelin-1 expression
SIX1 regulates dorsal arch development not only by inducing dorsal Jag1 expression but also by inhibiting endothelin 1 (Edn1) expression in the pharyngeal endoderm of the dorsal arch, thus preventing dorsal EDNRA signaling.
NOX4-derived reactive oxygen species in general, and possibly superoxide in particular, are involved in flow-stimulated inner medullary collecting duct ET-1 production.
in normal tissues the tandem of serine carboxypeptidases, Scpep1 and CathA likely constitutes an important part of the physiological mechanism responsible for the balanced elimination of heightened levels of ET-1 that otherwise would accumulate in tissues and consequently contribute to development of the hyper-proliferative corneal dystrophy and abnormal skin thickening
Newborn endothelial cells express high levels of ET-1 peptides, rapidly release ET-1 in response to endothelial stimulation, and initiate ET-1-mediated endothelium-dependent constriction
cellular and molecular mechanisms of ET-1 action in periodontitis
Taken together, these data indicate that during high-salt feeding, the autocrine actions of ET-1 via upregulation of the ETB receptor are critical for IMCD NO production, facilitating inhibition of ion reabsorption.
reduced lung levels of PPARgamma and increased levels of microRNA-27a (miR-27a), v-ets avian erythroblastosis virus E26 oncogene homolog 1 (ETS1), endothelin-1 (ET-1), and markers of endothelial dysfunction (platelet/endothelial cell adhesion molecule 1 and E selectin).
Increased circulating Edn1 and expression of Ednra in endothelial cells are characteristic of diabetic kidney disease-susceptible mice.
Review and Meta-Analysis of ET-1 Transgenic Mice provides robust evidence that global ET-1 overexpression in mice lowers blood pressure in an age-dependent manner. Older ET-1+/+ mice have a somewhat more pronounced reduction of blood pressure.
evidence supports a model in which aldosterone activation of the mineralocorticoid receptor (MR) results in the MR-hormone complex binding at HRE at -671bp to open chromatin structure around other regulatory elements in the Edn1 gene
Decreased ET-1 levels were associated with greater activation of NLRP3 and IL-1beta in normal glucose. High glucose increased NLRP3 markers and activation compared to normal and low glucose
AMPAR-mediated glutamatergic neurotransmission may underlie the mechanism of ET1-ET(A)R signaling pathway in the regulation of anxiety.
Phylogenetic analysis of conserved grhl-binding sites in gene regulatory regions identified endothelin-1 (edn1) as a putative direct grhl3 target gene, and this was confirmed by chromatin precipitation assays in embryos.
EDN1 plays an important role in hepatocellular carcinoma progression by activating the PI3K/AKT pathway and is regulated by miR-1.
Data suggest that edn1/ednraa (endothelin-1/endothelin-1 receptor type A) signaling is involved in acid-base regulation and transepithelial proton secretion via vacuolar proton-translocating ATPase in zebrafish embryonic skin.
These findings point to complexity of regulation by edn1 and hand2 at the earliest stages of pharyngeal arch development, in which control of growth and morphogenesis can be genetically separated.
Endothelin 1 combines with Bone Morphogenetic Proteins to pattern the dorsal-ventral axis of the craniofacial skeleton.
Development of lamprey mucocartilage and its dorsal-ventral patterning by endothelin signaling, with insight into vertebrate jaw evolution.
activation of Endothelin-1 signaling in craniofacial patterning
Edn1 from the pharyngeal ectoderm signals through Ednra proteins to direct early dorsoventral patterning of the skeletogenic neural crest.
The role of endothelin-1 and light in the regulation of melanopsins and the clock proteins in an embyronic cell line is reported.
EDN-1 may be involved in the protection of sperm from phagocytosis by polymorphonuclear neutrophils in the bovine oviduct, supporting sperm survival until fertilization
Data suggest that, in Fallopian tubes, endothelins (EDN1, EDN2, EDN3) and EDN-converting enzymes (ECE1, ECE2) are expressed in epithelial cells; EDN receptors (EDNRA, EDNRB) are present in smooth-muscle. Expression of EDN1, EDN2, and ECE2 is highest on day of ovulation. EDN/ENDR signaling appears to participate Fallopian tube function. These studies were conducted in Holstein cows.
results suggest that ET-1-induced activation of proMMP-2 is mediated via cross-talk between NADPH oxidase-PKCalpha-p(38)MAPK and NFkappaB-MT1MMP signaling pathways along with a marked decrease in TIMP-2 expression in the cells
We demonstrated that (i) treatment of bovine pulmonary artery smooth muscle cells with ET-1 stimulates cPLA2 activity in the cell membrane.
Differential cell-specific and spatiotemporal expression of the EDN1 system and NOS in the bovine utero-placental unit may be associated with regulation of vascular and cellular functions during pregnancy.
Oxidized LDL is a stimulus of ET-1 production in cultured vascular endothelial cells.
Endothelin-1 decreases ethanolamine plasmalogen levels and evokes platelet-activating factor production in brain microvessels
prostaglandin F2alpha, endothelin-1, and angiotensin II may interact with each other in a local positive feedback manner to activate their secretion in the regressing corpus luteum, thus accelerating and completing luteolysis
LOX-1 and CD40 synergistically, but through a distinct pathway, work to induce endothelin-1 expression in endothelial cells.
Elevated local expression of ET-1 and Ednra/Ednrb during the peri-ovulatory period induces the high contractile activity of the oviduct to optimize gamete transport.
Suggest that the activation of a local positive feedback mechanism in the corpus luteum among ET-1, Ang II and PGF2alpha might play a functional role in the paracrine modulation of luteolytic cascade.
The combined metabolic burden of homocysteine and high glucose stimulates ET-1 synthesis in bovine aortic endothelial cells via a mechanism dependent on the production of mitochondrial ROS, but may not be generalisable to all types of endothelial cells.
hypoxia and endothelin-1 have roles in mediating vasa vasorum neovascularization with pulmonary artery adventitial fibroblasts
The present study thus showed that neither leptin nor resistin affects the expression of endothelin-1 or adrenomedullin in bovine brain microvascular endothelial cells.
Intraluteal OXT may locally modulate secretion of vasoactive substances, particularly EDN1 and PGF(2alpha) within the corpus luteum.
Endothelin may be associated with final maturation of follicles.
Dehydroepiandrosterone stimulates phosphorylation of FoxO1 in vascular endothelial cells via phosphatidylinositol 3-kinase- and protein kinase A-dependent signaling pathways to regulate ET-1 synthesis and secretion
Short-term hyperinsulinaemia leads to increased vascular resistance in the equine digit and increased expression of ET-1 in the laminar tissue.
This is the first report describing the cDNA encoding preproendothelin-1 in an amphibian species.
A new role for et-1 signaling during early neural crest specification is reported.
The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene.
, gene for endothelin
, endothelin 1
, preproendothelin 1
, endothelin 1 L homeolog