Endothelin 1 antibody (C-Term)

Catalog No. ABIN655912

This Rabbit Polyclonal antibody specifically detects Endothelin 1 in WB, IF and IHC (p). It exhibits reactivity toward Human.

Quick Overview for Endothelin 1 antibody (C-Term) (ABIN655912)

Target: Endothelin 1 (EDN1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Endothelin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB20657

Product Details anti-Endothelin 1 Antibody

Binding Specificity: AA 176-203, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This EDN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176-203 amino acids from the C-terminal region of human EDN1.

Isotype: Ig Fraction

Application Details

Application Notes: IF: 1:10~50. WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for Endothelin 1

Target: Endothelin 1 (EDN1)

Alternative Name: EDN1

Background: The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 24425

Gene ID: 1906

NCBI Accession: NP_001161791, NP_001946

UniProt: P05305

Pathways: Hormone Transport, Negative Regulation of Hormone Secretion, Regulation of Systemic Arterial Blood Pressure by Hormones, cAMP Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of Cell Size