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anti-Human Endothelin 3 Antibodies:
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This is the first report of the cDNA encoding the precursor protein of ET-3 in a non-mammalian species.
the critical physiological role of the KIT-ET3-NO pathway in fulfilling high demand (exceeding basal level) of endothelium-dependent NO generation for coping with atherosclerosis, pregnancy, and aging, is reported.
genome-wide association studies in population of women in China: Data suggest that EDN3 (endothelin 3) and EDNRB (endothelin receptor type B) play important roles in the molecular mechanisms underlying cervical cancer.
EDN3 expression in left internal mammary arteries depends on tissue harvesting technique.
Down-regulated expression of ET3 attenuates the malignant behaviors of human melanoma cells partially by decreasing the expression of SPARC.
Waardenburg syndrome type II and mutations of EDNRB, EDN3 and SOX10 genes are responsible for Waardenburg syndrome type IV. (review)
Our data showed that almost all patients, regardless of individual characteristics such as gender or age, expressed the endothelin receptor genes, but did not express the genes for ET-3.
Studies revealed hypermethylation of EDN2 and EDN3 genes in human primary colon cancers and in a panel of human colon cancer cell lines. Epigenetic inactivation of ET-2 and ET-3 occurs frequently in both rat and human colon cancers.
plasma levels of big ET-2, and big ET-3 are markedly increased in patients with end stage renal disease on hemodialysis
A novel missense mutation in EDN3 and a deletion mutation in DMD has been found in the same Indian family members affected with Waardenburg syndrome and Duchenne muscular dystrophy.
These data suggest that autocrine EDN3/EDNRB signaling is essential for maintaining GSCs. Incorporating END3/EDNRB-targeted therapies into conventional cancer treatments may have clinical implication for the prevention of tumor recurrence.
ET-1 and the ET-1/ET-3 ratio are elevated in cirrhotic patients with portopulmonary hypertension (PPHT) and that ET-1 is associated with a poor outcome irrespective of PPHT.
Finding suggest that mutations in RET and NTRK3 acting together are necessary and sufficient for the appearance of Hirschsprung disease and that the EDN3 mutation acts as a phenotype modifier.
EDN3 may be considered as a common susceptibility gene for sporadic Hirschsprung disease in a low-penetrance fashion.
EDN3, in contrast to EDN1 and EDN2, may act as natural tumour suppressor in the human mammary gland
Mutations are found in Hirschsprung's disease in a Chinese population.
KEL6 red blood cells have endothelin-3-converting enzyme activity
neither polymorphism nor mutation was observed in EDN3 in Chinese Hirschprung disease patients
Endothelin-3 molecule is specifically upregulated in metastatic melanoma cells, showing that an abnormal autocrine stimulation pathway involving ET-3 is present in metastatic melanoma cells.
Endothelin signaling axis activates osteopontin expression through PI3 kinase pathway in A375 melanoma cells.
ET3 induced activation of IkappaB & MAPK in epithelial cells. ET3 is involved in regulating human colonic epithelial cell proliferation & survival, particularly for goblet cells.
study of the interplay between the EDN3 and beta1-integrin signalling pathways during ENS ontogenesis and the role of EDN3 in enteric neural crest cell adhesion
Control of differentiation of mouse enteric nervous system progenitor cells by EDN3 requires regulation of Ednrb expression by SOX10 and ZEB2.
Endothelin3 signaling has a critical role in development of UV-induced melanoma in a mouse model
colonic migrating motor complexes occur in mice lacking the endothelin-3 gene
Enterocolitis causes profound lymphoid depletion in endothelin receptor B- and endothelin 3-null mouse models of Hirschsprung-associated enterocolitis.
changes in spinal afferent innervation and visceral pain transmission from the aganglionic rectum in ls/ls mice with deletions of the endothelin-3 gene
EDN3 worked synergistically to induce melanocyte differentiation in vitro
a coordinate and balanced interaction between SOX10, endothelin-3 and endothelin B receptor is required for normal enteric nervous system and melanocyte development
Using quantitative real-time polymerase chain reaction (PCR) we demonstrated reduced levels of endothelin-3 mRNA in the male mouse bowel at the time that ENS precursors migrate into the colon.
an ENU-induced mutation in endothelin 3 results in a mouse model of Waardenburg syndrome type IV
Endothelin 3 induces skin pigmentation in a keratin-driven inducible mouse model.
Polymorphisms within the EDN3 gene are associated with meat color in the pig.
The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.
, endothelin 3
, lethal spotting