Endothelin 3 antibody (AA 168-197)

Catalog No. ABIN3030805

This Rabbit Polyclonal antibody specifically detects Endothelin 3 in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for Endothelin 3 antibody (AA 168-197) (ABIN3030805)

Target: Endothelin 3 (EDN3)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Endothelin 3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Endothelin 3 Antibody

Binding Specificity: AA 168-197

Purpose: EDN3 Antibody

Purification: Antigen affinity

Immunogen: A portion of amino acids 168-197 from the human protein was used as the immunogen for this EDN3 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the EDN3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the EDN3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Endothelin 3

Target: Endothelin 3 (EDN3)

Alternative Name: EDN3

Background: The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.

UniProt: P14138

Pathways: Hormone Transport, Negative Regulation of Hormone Secretion, Regulation of Systemic Arterial Blood Pressure by Hormones