Dacomitinib (PF299804, PF299)

Details for Product No. ABIN3220489
Inhibition Assay (InhA), Functional Studies (Func)
Purpose Dacomitinib(PF299804, PF-00299804) is a potent, orally available, irreversible tyrosine kinase HER 1 (EGFR), HER2 and HER4 inhibitor with IC50 of 6, 45.7 and 73.7 nM for EGFR, ERBB2 and ERBB4, respectively.
Characteristics Target: EGFR inhibitor, HER2 inhibitor
Receptor: EGFR/ErbB2/ErbB4
Purification All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
Purity 97 % +
Formula C24H25ClFN5O2
Solubility DMSO > 10 mM
Background JAK/STAT Signaling,Tyrosine Kinase/Adaptors
Molecular Weight 469.94 g/mol
CAS-No 1110813-31-4
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Solid
Storage -20 °C
Storage Comment For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
Expiry Date 24 months