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5-Azacytidine

Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
Catalog No. ABIN7233228
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Quick Overview for 5-Azacytidine (ABIN7233228)

Chemical Name

4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one

Permeability

Cell-permeable
  • Purpose

    DNA hypomethylation agent

    Characteristics

    Specific inhibitor of DNA methyltransferase1. Incorporates into DNA and covalently reacts with and inhibits DNA methyltransferases. Induces demethylation and reactivation of silenced genes2. Increases stem cell reprogramming efficiency3. Induces cardiac differentiation of human mesenchymal stem cells by activating ERK4. Induces apoptosis in multiple myeloma cells via ATR-mediated DNA double strand breaks5. Cell permeable.

    Purity

    >98 %

    Formula

    C8H12N4O5

    Solubility

    Soluble in DMSO (up to 25 mg/ml), or in Water (up to 12 mg/ml).
  • Restrictions

    For Research Use only
  • Format

    Powder

    Precaution of Use

    GHS – Classification
    Acute toxicity, Oral (Category 4), H302
    Germ cell mutagenicity (Category 2), H341
    Carcinogenicity (Category 1A), H350
    Reproductive toxicity (Category 1B), H360
    Specific target organ toxicity - repeated exposure (Category 1), H372
    Long-term (chronic) aquatic hazard (Category 1), H410

    Storage

    -20 °C

    Storage Comment

    -20°C
  • Background

    Ladakamycin, U-18496, NSC-102816, AzaC,Epigenetics,Chromatin,DNA methyltransferase,Stem cells,Cell death,Infectious disease,Apoptosis inducer,DNA damage

    Molecular Weight

    244.2

    CAS-No

    320-67-2
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