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- Application
- Inhibition (Inh)
- Purpose
- SIRT1 and 2 inhibitor
- Characteristics
- Activates p53 via inhibition of SIRT1 and SIRT2. Induces apoptosis in a variety of cancer cell lines including cutaneous T-cell lymphoma and melanoma among others. Induces cellular senescence in cultured rat primary astrocytes6 as well as other cell types.
- Purity
- >98 %
- Chemical Name
- N-[(4-Acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide
- Formula
- C20H23N3O2S
- Solubility
- Soluble in DMSO (up tp 10 mg/ml, warm)
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Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
RadicicolInh 12772-57-5
Geldanamycin- FITCInh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
NicotinamideInh 98-92-0 Pyridine-3-carboxylic acid amide
5-AzacytidineInh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
SAHA (Vorinostat)Inh Cell-permeable 149647-78-9 Suberoylanilide-hydroxamic acid
Phenylbutyrate NaInh 1716-12-7 4-Phenylbutyric acid, sodium salt
CI-994Inh 112522-64-2 4-(Acetylamino)-N-(2-aminophenyl)benzamide
Tranylcypromine hemisulfate (±)Inh Cell-permeable 13492-01-8 Trans (±)-2-phenylcyclopropanamine, hemisulfate salt
Sodium valproateInh 1069-66-5 2-Propylpentanoic acid Na
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- Restrictions
- For Research Use only
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- Format
- Powder
- Storage
- -20 °C
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- Background
- Posttranslational modification,Epigenetics,Chromatin,Cell cycle,Protein deacetylase,Transcription factor,Cancer,Senescence,p53
- Molecular Weight
- 369.5
- CAS-No
- 380315-80-0
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