BX795

Details for Product No. ABIN4875286
Application
Inhibition Assay (InhA), Functional Studies (Func)
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Purpose BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.
Characteristics Target: PDK inhibitor,c-Kit inhibitor, CDK inhibitor, PKA inhibitor
Receptor: PDE1/TBK1,c-kit,CDK2,PKA
Purification All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
Purity 98 %
Formula C23H26IN7O2S
Solubility DMSO > 100mM
Background Cell Cycle/Checkpoint,PI3K/Akt/mTOR Signaling,Tyrosine Kinase/Adaptors
Molecular Weight 591.47 g/mol
CAS-No 702675-74-9
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Solid
Storage -20 °C
Storage Comment For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
Expiry Date 24 months