Application: Inhibition Assay (InhA), Functional Studies (Func)
Purpose: Zonisamide is a sulfonamide anticonvulsant approved for use as an adjunctive therapy in adults with partial-onset seizures. Zonisamide may be a carbonic anhydrase inhibitor although this is not one of the primary mechanisms of action. Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels leading to a reduction of T-type calcium channel currents, or by binding allosterically to GABA receptors. This latter action may inhibit the uptake of the inhibitory neurotransmitter GABA while enhancing the uptake of the excitatory neurotransmitter glutamate.
Characteristics: Tradename: ZONEGRAN
Source of Compound: synthetic
Target: Carbonic anhydrase inhibitor,Calcium Channel inhibitor,Sodium Channel inhibitor
Receptor: CA,Calcium Channel,Sodium channel
Purification: All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
Purity: 98 %
Formula: C8H8N2O3S
Solubility: Soluble in DMSO

Geldanamycin

Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Radicicol

Inh 12772-57-5

Geldanamycin- FITC

Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Nicotinamide

Inh 98-92-0 Pyridine-3-carboxylic acid amide

5-Azacytidine

Inh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one

SAHA (Vorinostat)

Inh Cell-permeable 149647-78-9 Suberoylanilide-hydroxamic acid

Phenylbutyrate Na

Inh 1716-12-7 4-Phenylbutyric acid, sodium salt

CI-994

Inh 112522-64-2 4-(Acetylamino)-N-(2-aminophenyl)benzamide

Tranylcypromine hemisulfate (±)

Inh Cell-permeable 13492-01-8 Trans (±)-2-phenylcyclopropanamine, hemisulfate salt

Tenovin-1

Inh 380315-80-0 N-[(4-Acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide

Application Notes: Optimal working dilution should be determined by the investigator.
Restrictions: For Research Use only

Format: Solid
Storage: -20 °C
Storage Comment: For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
Expiry Date: 24 months

Background: Membrane Transporter/Ion Channel,Metabolism
Molecular Weight: 212.23 g/mol
CAS-No: 68291-97-4

Zonisamide

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