Application: Inhibition Assay (InhA), Functional Studies (Func)
Purpose: A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Characteristics: Tradename: CLOZARIL
Source of Compound: synthetic, HF-1854
Target: Histamine Receptor antagonist,5-HT receptor antagonist,AChR antagonist,Adrenergic Receptor agonist ,Dopamine Receptor antagonist
Receptor: Histamine receptor,5-HT Receptor,Muscarinic AChR,β-adrenergic receptor,Dopamine receptor
Purification: All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
Purity: 98 %
Formula: C18H19ClN4
Solubility: Water: 11.8 mg/L

Geldanamycin

Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Radicicol

Inh 12772-57-5

Geldanamycin- FITC

Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Nicotinamide

Inh 98-92-0 Pyridine-3-carboxylic acid amide

5-Azacytidine

Inh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one

SAHA (Vorinostat)

Inh Cell-permeable 149647-78-9 Suberoylanilide-hydroxamic acid

Phenylbutyrate Na

Inh 1716-12-7 4-Phenylbutyric acid, sodium salt

CI-994

Inh 112522-64-2 4-(Acetylamino)-N-(2-aminophenyl)benzamide

Tranylcypromine hemisulfate (±)

Inh Cell-permeable 13492-01-8 Trans (±)-2-phenylcyclopropanamine, hemisulfate salt

Tenovin-1

Inh 380315-80-0 N-[(4-Acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide

Application Notes: Optimal working dilution should be determined by the investigator.
Restrictions: For Research Use only

Format: Solid
Storage: -20 °C
Storage Comment: For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
Expiry Date: 24 months

Background: Neuroscience
Molecular Weight: 326.82 g/mol
CAS-No: 5786-21-0

Clozapine

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