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CPI-455

Inh 1628208-23-0 7-Oxo-5-phenyl-6-propan-2-yl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile

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Catalog No. ABIN7233243

Datasheet as PDF

Application

Inhibition (Inh)

Purpose

Lysine demethylase KDM5 inhibitor

Characteristics

CPI-455 (1628208-23-0) is a potent (IC50 = 10 nM) and selective inhibitor of the lysine demethylase KDM5 (equal inhibition of KDM5A, 5B, 5C). CPI-455 reduced the number of drug-tolerant persister cancer cells (DTPs) in a dose-dependent, KDM5-dependent manner in multiple cell lines treated with standard chemotherapy or targeted agents. CPI-455 synergized with 5-aza-2'-deoxycytidine (DAC) to reduce the viability of luminal breast cancer cells in vitro. KDM5 demethylases have recently been shown to repress the immune response to tumors via suppression of STING.

Purity

>98 %

Chemical Name

7-Oxo-5-phenyl-6-propan-2-yl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile

Formula

C16H14N4O

Solubility

Soluble in DMSO (up to at least 25 mg/ml)
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Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Radicicol
Inh 12772-57-5

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Phenylbutyrate Na
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Tranylcypromine hemisulfate (±)
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Tenovin-1
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Restrictions

For Research Use only
Format

Powder

Storage

-20 °C
Background

Epigenetics,Chromatin,Protein demethylase,STING,Immunology,Cancer,Posttranslational modification,Cytokine

Molecular Weight

278.32

CAS-No

1628208-23-0