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Mouse (Murine) Polyclonal HTR2C Primary Antibody for IEM, ICC - ABIN617931
Holmes: 5-Hydroxytryptamine2C receptors on pudendal motoneurons innervating the external anal sphincter. in Brain research 2005
Show all 4 Pubmed References
Human Polyclonal HTR2C Primary Antibody for ELISA, WB - ABIN250397
Castensson, Aberg, McCarthy, Saetre, Andersson, Jazin: Serotonin receptor 2C (HTR2C) and schizophrenia: examination of possible medication and genetic influences on expression levels. in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2005
Our work suggests that the studied polymorphisms, 5HT1A (rs6295), 5HT1B (rs6296), and 5HT2C (rs6318), were not related to the presence of temporal lobe epilepsy (TLE), psychiatric comorbidities in TLE, and epilepsy-related factors.
Demonstrated that a 5-HT2AR:5-HT2CR interaction occurs in cultured cells using three complementary biophysical techniques with increasing spatial resolution. Findings indicate these receptors form a close biophysical interaction within 10 nm in living cells.
two structures of the 5-HT2C receptor in complex with the highly promiscuous agonist ergotamine and the 5-HT2A-C receptor-selective inverse agonist ritanserin at resolutions of 3.0 A and 2.7 A, respectively.
The multivariate analysis showed the following factors as associated with the polymorphism: higher cigarette consumption, being a woman, and not having abdominal obesity. The area under the ROC curve was 0.706. An association was found between increased cigarette consumption over the years and the presence of the C allele of the rs1414334 polymorphism in the HTR2C gene
The study emphasised the potential role of 5HT2C receptor gene polymorphisms in Egyptian patients with lifelong premature ejaculation.
No differences were found between murderers and thieves either concerning 5HTTLPR and 5-HT2C genotypes or concerning psychological measures. Comparison of polymorphism distribution between groups of prisoners and controls revealed highly significant associations of 5HTTLPR and 5-HTR2C (rs6318) gene polymorphisms with being convicted for criminal behavior.
Genetic variants in HTR2C are involved in the susceptibility to metabolic syndrome in patients treated with atypical antipsychotics.
The presence of the G allele of rs6318 of the HTR2C gene was found to be associated with characteristics of aggressive behavior and social problems, and aggressive behavior was found to be associated with heterozygosis in females.
The aim of our study was to explore the role of the HTR2C gene variant Cys23Ser (rs6318) in the pathogenesis of suicidal behavior through a systematic review and meta-analysis. Our findings suggest that the rs6318 (Cys23Ser) polymorphism is not associated with suicidal behavior.
The constitutive activity of 5HT2C is decreased by pre-mRNA editing as well as alternative pre-mRNA splicing, which generates a truncated isoform that switches off 5HT2C receptor activity through heterodimerization; showing that RNA processing regulates the constitutive activity of the 5HT2C system.
The results suggest that region-specific changes in RNA editing of 5-HT2CR mRNA and deficient receptor function likely contribute to the etiology of major depressive disorder or suicide.
Therefore, the 5-HT2C gene polymorphism rs3813929 (more specifically, the TT genotype) predicted greater %EWL 12 months after RYGB surgery among female patients.
findings indicate that polymorphisms rs3813929 and rs1800849 from 5-HT2C and UCP3 genes were related to type 2 diabetes mellitus prevalence among the Brazilian obese women candidates for bariatric surgery.
A significant association was established between various HTR2C polymorphisms and Hyperprolactinaemia (HPRL). The study revealed an association between HPRL and X-chromosome haplotypes comprised of the rs569959 and rs17326429 polymorphisms.
C-carriers showed blunted rather than exaggerated cortisol responses to lab-induced stress in multilevel models (b=0.467, p<0.001), which persisted when covarying subclinical depressive symptoms. This effect was not moderated by sex. Results support a role for the rs6318 C-allele in dysregulated stress responding, and suggest that the C-allele may contribute to risk for depression.
We examined cortisol reactivity to a social evaluative stressor in the laboratory. The HTR2C Cys23 allele was associated with greater cortisol reactivity. The consistency of the results across the two sites in this paper as well as the additional site in the companion paper (total N = 426) provides strong support for an association of the Cys23Ser polymorphism with cortisol reactivity in the Trier Social Stress Test.
Authors found that 22 patients presented the -759C/T polymorphism in 5-HTR2C gene.
heterodimerization with 5-HT2C receptors does not alter 5-HT2C Galphaq-dependent inositol phosphate signaling, 5-HT2A or 5-HT2B receptor-mediated signaling was totally blunted. This feature can be explained by a dominance of 5-HT2C on 5-HT2A and 5-HT2B receptor binding; in 5-HT2C-containing heterodimers, ligands bind and activate the 5-HT2C protomer exclusively.
This study demonstrated that -759C>T Polymorphism of the HTR2C Gene is Associated with Second Generation Antipsychotic-Induced Weight Gain in Female Patients with Schizophrenia.
the occurrence of hyperprolactinemia, although asymptomatic, was higher in the presence of the C allele of the rs6318 SNP of the HTR2C gene.
RNA splicing and editing modulation of 5-HT2CR function is relevant to aggression in VGV (full edited VGV isoform of 5-HT2CR) mice.
interplay between 5-HT2C and 5-HT1A receptors in the dorsal periaqueductal gray in the modulation of fear-induced antinociception in mice
The 5-HT2C receptor mRNA is expressed in the posterior pituitary gland.
Results indicate that 5-HT may facilitate nociception and intensify fear-induced antinociception, respectively, at 5-HT1A and 5-HT2C receptors located in the amygdala of mice. The impairment produced by systemic fluoxetine on fear-induced antinociception provoked by intra-amygdala MK-212 suggests that this type of fear-induced antinociception may be modulated by serotonin reuptake inhibitors.
cortisol up-regulated the expression and function of two serotonin (S) receptors, HTR2c and HTR5a.
Activation of the subpopulation of 5-HTCR neurons within the ventral tegmental area is sufficient to reduce homeostatic feeding.
Data suggest that Htr2c and leptin in hypothalamic nuclei may be involved in the effects of corticosterone on food intake/appetite regulation. (Htr2c = 5-hydroxytryptamine type 2C receptor)
These data provide new insight into the significance of Htr2c pre-mRNA processing to the physiological regulation of appetite and potentially the pathological manifestation of hyperphagia in Prader-Willi syndrome.
olanzapine exerts some of its untoward metabolic effects via antagonism of HTR2C
5HTR2C regulates neurite growth and RGC activity and is necessary for normal amplitude of RGC response to physiologic stimuli.
Study identified the 5-hydroxytryptamine (5-HT) 2C receptor (5-HT2CR) population in DA neurons as one potential target for antibinge therapies, and provided preclinical evidence that 5-HT2CR agonists could be used to treat binge eating.
Both dorsal raphe serotonergic activity during aversive reinforcement and amygdala serotonin 2C receptor (5-HT2CR) activity during memory consolidation were necessary for stress enhancement of fear memory, but neither process affected fear memory in unstressed mice. Prior stress increased amygdala sensitivity to serotonin by promoting 5-HT2CR surface expression without affecting tissue levels of serotonin in the amygdala.
results demonstrate that CHL1 regulates signal transduction pathways through constitutively active 5-HT2c receptor isoforms, thereby altering 5-HT2c receptor functions and implicating CHL1 as a new modulator of the serotonergic system.
Social Behavioral Deficits Coincide with the Onset of Seizure Susceptibility in Mice Lacking Serotonin Receptor 2c.
Study demonstrates that the GHS-R1a/5-HT2C receptor interaction translates into a biologically significant modulation of ghrelin's orexigenic effect
This study showed that reduced expression of the 5ht1c which modulate antidepressant action in hippocampus.
Suppressed feeding behavior in novelty stress-exposed aged male mice may be mediated by 5-HT(2C)R hypersensitivity, leading to hypoghrelinemia. The hypersensitivity may partly be due to estrogen receptor activation in aged male mice.
Results show that mice solely expressing the unedited INI form of 5-HT2C receptors exhibit a hyperactive HPA axis driven by increased CRH, a normal response to chronic stress and decreased depressive-like behaviors and fear-associated memory
The direct reinforcing effects of a 5-HT(2C)R-selective antagonist in any species.
5HT1A receptor may lose sensitivity to the suppressive effect of estradiol after 5 months, whereas the 5HT2C receptor increases, however, addition of progesterone in the EP5 regimen maintains the regulatory effects
5-HT(2) receptors are coupled to phospholipase C in bovine ciliary epithelium.
although the expression of the long transcriptional variant of HTR2C is raised in infanticidal animals, the overall patterns of editing in the hypothalamus are similar between the two states.
Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. Three transcript variants encoding two different isoforms have been found for this gene.
, 5-hydroxytryptamine receptor 1C
, 5-hydroxytryptamine receptor 2C
, 5-hydroxytryptamine receptor-1c
, serotonin 5-HT-2C receptor
, serotonin receptor 2C
, 5-HT2C receptor
, serotonin 1c receptor
, 5-hydroxytryptamine (serotonin) receptor 2C
, 5HT2C serotonin receptor
, 5-alpha-hydroxytryptamine receptor 2C
, 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled