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Mouse (Murine) Polyclonal HTR2C Primary Antibody for IEM, ICC - ABIN617931
Holmes: 5-Hydroxytryptamine2C receptors on pudendal motoneurons innervating the external anal sphincter. in Brain research 2005
Show all 4 Pubmed References
Human Polyclonal HTR2C Primary Antibody for ELISA, WB - ABIN250397
Castensson, Aberg, McCarthy, Saetre, Andersson, Jazin: Serotonin receptor 2C (HTR2C) and schizophrenia: examination of possible medication and genetic influences on expression levels. in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2005
The aim of our study was to explore the role of the HTR2C gene variant Cys23Ser (rs6318) in the pathogenesis of suicidal behavior through a systematic review and meta-analysis. Our findings suggest that the rs6318 (Cys23Ser) polymorphism is not associated with suicidal behavior.
The constitutive activity of 5HT2C is decreased by pre-mRNA editing as well as alternative pre-mRNA splicing, which generates a truncated isoform that switches off 5HT2C receptor activity through heterodimerization; showing that RNA processing regulates the constitutive activity of the 5HT2C system.
The results suggest that region-specific changes in RNA editing of 5-HT2CR mRNA and deficient receptor function likely contribute to the etiology of major depressive disorder or suicide.
Therefore, the 5-HT2C gene polymorphism rs3813929 (more specifically, the TT genotype) predicted greater %EWL 12 months after RYGB surgery among female patients.
findings indicate that polymorphisms rs3813929 and rs1800849 from 5-HT2C and UCP3 (show UCP3 Antibodies) genes were related to type 2 diabetes mellitus prevalence among the Brazilian obese women candidates for bariatric surgery.
A significant association was established between various HTR2C polymorphisms and Hyperprolactinaemia (HPRL). The study revealed an association between HPRL and X-chromosome haplotypes comprised of the rs569959 and rs17326429 polymorphisms.
We examined cortisol reactivity to a social evaluative stressor in the laboratory. The HTR2C Cys23 allele was associated with greater cortisol reactivity. The consistency of the results across the two sites in this paper as well as the additional site in the companion paper (total N = 426) provides strong support for an association of the Cys23Ser polymorphism with cortisol reactivity in the Trier Social Stress Test.
Authors found that 22 patients presented the -759C/T polymorphism in 5-HTR2C gene.
heterodimerization with 5-HT2C receptors does not alter 5-HT2C Galphaq-dependent inositol phosphate signaling, 5-HT2A or 5-HT2B receptor-mediated signaling was totally blunted. This feature can be explained by a dominance of 5-HT2C on 5-HT2A and 5-HT2B receptor binding; in 5-HT2C-containing heterodimers, ligands bind and activate the 5-HT2C protomer exclusively.
This study demonstrated that -759C>T Polymorphism of the HTR2C Gene is Associated with Second Generation Antipsychotic-Induced Weight Gain in Female Patients with Schizophrenia.
Data suggest that Htr2c and leptin (show LEP Antibodies) in hypothalamic nuclei may be involved in the effects of corticosterone on food intake/appetite regulation. (Htr2c = 5-hydroxytryptamine type 2C receptor)
These data provide new insight into the significance of Htr2c pre-mRNA processing (show PRPF39 Antibodies) to the physiological regulation of appetite and potentially the pathological manifestation of hyperphagia in Prader-Willi syndrome.
olanzapine exerts some of its untoward metabolic effects via antagonism of HTR2C
5HTR2C regulates neurite growth and RGC activity and is necessary for normal amplitude of RGC response to physiologic stimuli.
Study identified the 5-hydroxytryptamine (5-HT) 2C receptor (5-HT2CR) population in DA neurons as one potential target for antibinge therapies, and provided preclinical evidence that 5-HT2CR agonists could be used to treat binge eating.
Both dorsal raphe serotonergic activity during aversive reinforcement and amygdala serotonin 2C receptor (5-HT2CR) activity during memory consolidation were necessary for stress enhancement of fear memory, but neither process affected fear memory in unstressed mice. Prior stress increased amygdala sensitivity to serotonin by promoting 5-HT2CR surface expression without affecting tissue levels of serotonin in the amygdala.
results demonstrate that CHL1 regulates signal transduction pathways through constitutively active 5-HT2c receptor isoforms, thereby altering 5-HT2c receptor functions and implicating CHL1 as a new modulator of the serotonergic system.
Social Behavioral Deficits Coincide with the Onset of Seizure Susceptibility in Mice Lacking Serotonin Receptor 2c.
The direct reinforcing effects of a 5-HT(2C)R-selective antagonist in any species.
5HT1A (show HTR1A Antibodies) receptor may lose sensitivity to the suppressive effect of estradiol after 5 months, whereas the 5HT2C receptor increases, however, addition of progesterone in the EP5 regimen maintains the regulatory effects
5-HT(2) receptors are coupled to phospholipase C (show PLC Antibodies) in bovine ciliary epithelium.
although the expression of the long transcriptional variant of HTR2C is raised in infanticidal animals, the overall patterns of editing in the hypothalamus are similar between the two states.
Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. Three transcript variants encoding two different isoforms have been found for this gene.
, 5-hydroxytryptamine receptor 1C
, 5-hydroxytryptamine receptor 2C
, 5-hydroxytryptamine receptor-1c
, serotonin 5-HT-2C receptor
, serotonin receptor 2C
, 5-HT2C receptor
, serotonin 1c receptor
, 5-hydroxytryptamine (serotonin) receptor 2C
, 5HT2C serotonin receptor
, 5-alpha-hydroxytryptamine receptor 2C
, 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled