Browse our Methyl CpG Binding Protein 2 Proteins (MECP2)

Human Methyl CpG Binding Protein 2 (MECP2) interaction partners

1. Autism-related protein MeCP2 regulates FGF13 expression and emotional behaviors

2. the apparent length-dependent trends previously observed in MeCP2 microarray and RNA-sequencing datasets disappear after estimating baseline variability from randomized control samples.

3. our data suggest that MeCP2 plays an essential role in TGF-beta1-induced myofibroblast differentiation and extracellular matrix production in nasal polyp-derived fibroblasts

4. These findings highlight the critical role of miR-137-c-Met nexus in colorectal cancer (CRC) development and reveal Mecp2-regulated epigenetic silence causes the downregulation of miR-137 in colorectal adenoma and carcinoma.

5. Here we report a 10-year--10-months old male patient having overlapping clinical features of MECP2 duplication syndrome, AS and ASDs. He had mental retardation, lack of speech and developmental delay, and also dysmorphic features such as plagiocephaly, retrognathia, hyperextensible joints in fingers and elbows, broad great toe and three different sizes of cafe au laits.

6. These data showed an intimate interplay among miR-19a/b methylation, MeCP2 activity, and multidrug resistance, revealing a potential therapeutic target for gastric cancer.

7. In an Indian population, the yield of the mutation detection in MECP2 is higher in classical Rett syndrome. In girls with some Rett like features, but not fulfilling revised Rett syndrome diagnostic criteria, mutation testing for MECP2 gene has a low yield.

8. C5-cytosine methylation entropically favors complexation by the MBD domain of the human MeCP2 protein with almost no contribution of the binding enthalpy.

9. The authors find that astrocyte stimulation in wild-type mice increases excitatory synaptic activity that is absent in male mice lacking MeCP2 globally. The defect is dependent upon MeCP2 expression status in the astrocytes and not in the neurons.

10. These dysregulated genes provide a better understanding of the underlying mechanisms of the effect of MeCP2 on heart failure and might be used as targets and prognostic markers of heart failure.

11. MECP2 gene rs17435 polymorphism was associated with juvenile idiopathic arthritis predisposition. Considering the involvement of genetic polymorphisms of MECP2 gene in susceptibility to adult-onset RA, this gene might basically play a role in the initiation of arthritis during early stages of life.

12. MECP2 is not associated with disease susceptibility in JSLE patients, implying the involvement of different susceptibility genes in the pathogenesis of Systemic Lupus Erythematosus and Juvenile-Onset Systemic Lupus Erythematosus

13. We report on two dizygotic twins with an MECP2-related psychiatric disorder without intellectual disability. We found a c.491G>T [ChrX:153296788C>A (Hg19)] transversion in exon 4 of the MECP2 gene in both patients. It was predicted to change a highly conserved serine to isoleucine, p.(Ser164Ile)

14. Males with Rett syndrome and missense mutations in MECP2 display a phenotype that correlates with impaired function of MECP2.

15. Tyr120Asp mutation alters domain flexibility and dynamics of MeCP2 DNA binding domain leading to impaired DNA interaction

16. This study suggests that methylation of Wnt pathway genes, in addition to known CpG island methylator phenotype markers, may help predict treatment outcome and survival in patients with CRC[colorectal cancer.

17. Results show that highly expressed phospho-MeCP2-S421 and its association with VEGF in proliferative diabetic retinopathy (PDR) membranes suggests that phospho-MeCP2-S421 might involve in the pathogenesis of PDR.

18. MeCP2 behaves similarly to histone H1 and HMGD1 in creating a higher-order chromatin structure, which is susceptible to chromatin remodeling by ISWI.

19. these lines of evidence strongly suggest that MeCP2-P152L, MeCP2-R294X, and MeCP2-P376S, identified in autism patients, affect the proper physiological functions of the MeCP2 protein and thus may contribute the pathogenesis of autism.

20. Data show that miR-98 could inhibit Mecp2 expression by binding the 3'-untranslated region (UTR) of methyl CpG binding protein 2 (Mecp2).

Mouse (Murine) Methyl CpG Binding Protein 2 (MECP2) interaction partners

1. Autism-related protein MeCP2 regulates FGF13 expression and emotional behaviors

2. MeCP2 interacts with microRNAs in mouse primary cortical neurons.

3. the apparent length-dependent trends previously observed in MeCP2 microarray and RNA-sequencing datasets disappear after estimating baseline variability from randomized control samples.

4. MeCP2 expression in the excitatory cells of mouse visual thalamus

5. Pup gathering behaviour and associated auditory cortical plasticity are impaired in female Mecp2 knockout mice.

6. Decreased MeCP2 binding near splice junctions facilitates intron retention via reduced recruitment of splicing factors, including Tra2b, and increased RNA polymerase II stalling.

7. we found that MeCP2 plays a critical role in regulating fate determination of adult NSCs. These evidences further suggest that abnormal development of NSCs may play a role in the pathogenesis of the MECP2 duplication syndrome.

8. MeCP2 regulated mRNA splicing in the brain through interacting with 5-hydroxymethylcytosine and epigenetic changes in histone markers.

9. Study in female mouse model for Rett syndrome shows that low-level MECP2 expression in the brain can have a disproportionately positive impact on health and survival.

10. genetic reactivation of Xi-linked Mecp2 in cerebral cortical neurons of living mice bearing a homozygous XCIF deletion. Collectively, our results further establish the feasibility of pharmacological reactivation of Xi-linked MECP2 as a therapeutic approach for RTT.

11. Authors used a well-characterized motor suppressive effect of nAChR agonists on mouse open field locomotor behavior to probe effects of MeCP2 mutation on cholinergic transmission.

12. Protein levels of p-MeCP2 were increased in high glucose or TGF-beta-treated mouse glomerular mesangial cells. The SIAH1/HIPK2/MeCP2 axis played a novel role for in suppressing miR-25 processing and thereby upregulating NOX4 in early diabetic nephropathy.

13. Study shows defective GABAergic neurotransmission in the nucleus tractus solitarius (NTS) methyl-CpG binding protein 2-null mice, a model of Rett syndrome. In addition the study found an increase in the delta subunit of the GABAA-receptors in the NTS in Mecp2-null mice, consistent with increased extrasynaptic receptors.

14. The results of this study indicated significant structural and functional impairments in the barrel cortex of animal model for the Rett syndrome.

15. disruption of AT-hook 1 domain in MeCP2 caused behavioral abnormality in mice, which suggests that AT-hook 1 is a critical region for the function of MeCP2 protein

16. temporal regulation of S164 phosphorylation controls the ability of MeCP2 to regulate neuronal morphology.

17. Two putative modulators of MeCP2, HIPK2 (homeodomain-interacting protein kinase 2) and PP2A (protein phosphatase 2A), were validated as stabilizers of MeCP2 in vivo.

18. BMP/TGF-beta signaling pathway regulates X-inactive specific transcript (XIST), and whose down-regulation reactivated the methyl CpG binding protein 2 (MeCP2) reporter on the inactive X chromosome (Xi).

19. These subtle changes in myelinated peripheral nerve fibers in heterozygous Mecp2 knockout mice could potentially explain some RTT phenotypes.

20. MeCP2 tunes gene expression in neurons by binding within the transcribed regions of genes to impede the elongation of RNA polymerase

Zebrafish Methyl CpG Binding Protein 2 (MECP2) interaction partners

1. Mecp2 is required for tnfa expression during zebrafish development and inflammation.

2. The results of this study imply that Mecp2 is an important functional regulator of bdnf gene expression during neural circuit formation in zebrafish embryo

3. a proteomic analysis to examine protein expression changes in mecp2-null vs. wild-type larvae and adult zebrafish

4. A mecp2-null allele mutation zebrafish model is developed and the animals are viable and fertile.