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Human Polyclonal PPIP5K1 Primary Antibody for ICC, IF - ABIN4317533
Yousaf, Gu, Ahmed, Khan, Friedman, Riazuddin, Shears, Riazuddin: Mutations in Diphosphoinositol-Pentakisphosphate Kinase PPIP5K2 are associated with hearing loss in human and mouse. in PLoS genetics 2018
PPIP5K is a rare example of a single protein that catalyzes a kinase/phosphatase futile cycle. (Review)
This study characterized kinetic properties of the bifunctional inositol pyrophosphate 5-diphosphoinositol 1,2,3,4,6-pentakisphosphatekinase/inositol pyrophosphate, 1,5-bisdiphosphoinositol 2,3,4,6-tetrakisphosphate phosphatase activities of full-length diphosphoinositol pentakisphosphate kinase 1 and 2.
results suggest that PPIP5K1 might play an important role in regulating function of exocyst complex in establishing cellular polarity and directional migration of cells
Upon activation of the appropriate cell-surface receptors to stimulate PtdIns(3,4,5)P3 synthesis, human PPIP5K1 translocates from the cytoplasm to the plasma membrane.
This gene encodes a dual functional inositol kinase. The encoded enzyme converts inositol hexakisphosphate to diphosphoinositol pentakisphosphate and diphosphoinositol pentakisphosphate to bis-diphosphoinositol tetrakisphosphate. This protein may be important for intracellular signaling pathways. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 15.
, VIP1 homolog
, histidine acid phosphatase domain containing 2A
, histidine acid phosphatase domain-containing protein 2A
, inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
, inositol pyrophosphate synthase 1
, insP6 and PP-IP5 kinase 1
, PP-IP5 kinase 1
, diphosphoinositol pentakisphosphate kinase 1
, Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1