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anti-Human NCOA2 Antibodies:
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Human Polyclonal NCOA2 Primary Antibody for ICC, IF - ABIN151282
Tognoni, Chadwick, Ackeifi, Tetel: Nuclear receptor coactivators are coexpressed with steroid receptors and regulated by estradiol in mouse brain. in Neuroendocrinology 2011
Show all 3 Pubmed References
Cow (Bovine) Polyclonal NCOA2 Primary Antibody for WB - ABIN2780788
Strehl, Nebral, König, Harbott, Strobl, Ratei, Struski, Bielorai, Lessard, Zimmermann, Haas, Izraeli: ETV6-NCOA2: a novel fusion gene in acute leukemia associated with coexpression of T-lymphoid and myeloid markers and frequent NOTCH1 mutations. in Clinical cancer research : an official journal of the American Association for Cancer Research 2008
Using quantitative biochemical, biophysical, and solution structural methods study shows that ligand and DNA cooperatively recruit the intrinsically disordered steroid receptor coactivator-2 (SRC-2/TIF2/GRIP1/NCoA-2) receptor interaction domain to peroxisome proliferator-activated receptor gamma (show PPARG Antibodies)-retinoid X receptor alpha (show RXRA Antibodies) (PPARgamma (show PPARG Antibodies)-RXRalpha (show RXRA Antibodies)) heterodimer and reveal the binding determinants of the complex.
T3 promotes differentiation towards chondrocytes-like cells in our in vitro model, that this differentiation is mediated by steroid receptor (show ESR2 Antibodies) co-activator 2 (SRC2) and does not induce hypertrophy
Pancreatic involvement occurs in mesenchymal chondrosarcoma harboring the HEY1 (show HEY1 Antibodies)-NCOA2 gene fusion.
Data suggest that steroid receptor (show ESR2 Antibodies) coactivators (NCOA1 (show NCOA1 Antibodies), NCOA2, NCOA3 (show NCOA3 Antibodies)) are over-expressed in a number of hormone-dependent cancers where they promote tumor growth, invasion, metastasis, and chemo-resistance; with their multiple roles in cancer, steroid receptor (show ESR2 Antibodies) coactivators are promising targets for development of antineoplastic agents that can interfere with their function. [REVIEW]
SRC-2 may exhibit oncogenic or tumor suppressor activity depending on the target genes and nuclear receptors that are expressed in distinct tissues
NCOA2ETV4 protein would contain the helixloophelix, PAS_9 and PAS_11, CITED domains, the SRC1 (show SRC Antibodies) domain of NCOA2 and the ETS (show ETS1 Antibodies) DNAbinding domain of ETV4 (show ETV4 Antibodies).
Altered expression of TIF2 may play a role in adenomyosis development and treatment outcome with levonorgestrel-releasing intrauterine system.
evaluating if NCOA2 relative copy-number gain presents prognostic value for prostate cancer
Report NcoA2-regulation of the AhR (show AHR Antibodies)-ARNT (show ARNT Antibodies)-HIF-1a (show HIF1A Antibodies) interaction.
Data suggest that LRH1/NR5A2 (show NR5A2 Antibodies) (liver receptor homologue-1) exhibits phospholipid-mediated allosteric control of protein-protein binding interface in interactions with TIF2 and SHP (show LAMC1 Antibodies) (co-repressor; small heterodimer partner (show NR0B2 Antibodies) protein).
studies demonstrate that SRC-2 provides an essential link between the behavioral activities influenced by light cues and the metabolic homeostasis maintained by the liver
the expression of MOZ-TIF2 fusion protein represses the transcription of p16INK4a and p19ARF and blocks senescence.
findings position SRC-2 as a major regulator of polygenic inputs to metabolic gene regulation and perhaps identify a previously unappreciated model that helps to explain the clinical spectrum of glucose dysregulation
fetal lungs produce signals to initiate labor when mature, and SRC-1 (show NCOA1 Antibodies)/-2-dependent production of SP-A (show SFTPA1 Antibodies) and PAF (show PAF Antibodies) is crucial for this process
In a murine model, overexpression of NCoA2 in the prostate epithelium resulted in neoplasia.
the PAX3 (show PAX3 Antibodies)-NCOA2 fusion gene has a dual role in the tumorigenesis of rhabdomyosarcoma
Transcription factor 23 (Tcf23 (show TCF23 Antibodies)), a basic-helix-loop-helix transcription factor (show HEY1 Antibodies), is a new progesterone-induced target gene that requires SRC-2 for full induction.
SRC-2 is a transcriptional coactivator for BMAL1 (show ARNTL Antibodies):CLOCK. Ablation of SRC-2 disrupts the central clock.
SRC-2 is critical to transcriptional control modulated by MEF2 (show MEF2C Antibodies), GATA-4 (show GATA4 Antibodies), and Tbx5 (show TBX5 Antibodies), thereby enhancing gene expression associated with cardiac growth.
SRC2 regulates anxiety response with SRC2(-/-) females showing decreased anxiety in novel environments.
The tif2 is involved in embryogenesis and in primitive hematopoiesis. tif2-knockdown zebrafish embryos are smaller than controls.
SNP 1718 in the NCOA2 gene was significant for early pregnancy probability (P=0.02) and age at first calving (P=0.03), and SNP 2038 in the same gene was significant for days to calving (P=0.03).
The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below), are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 (MIM 140571) and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene's transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation (Hong et al., 1997
class E basic helix-loop-helix protein 75
, glucocorticoid receptor-interacting protein-1
, transcriptional intermediary factor 2
, glucocorticoid receptor interacting protein 1
, glucocorticoid receptor-interacting protein 1
, steroid receptor coactivator 2
, nuclear receptor coactivator 2
, transcriptional intermediary factor-2
, Transcriptional intermediary factor 2
, nuclear receptor coactivator 2-like