Recombinant Human IgG2 Isotype Control
In vivo Grade
IsoC, in vivo
IgG2
Recombinant Antibody
unconjugated
Catalog No. ABIN7211742
-15% Promotion 2026
$555.77
save $98.08 (-15 %)
Plus shipping costs $50.00
1 mg
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United States
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Quick Overview for Recombinant Human IgG2 Isotype Control (ABIN7211742)
Target
IgG2
Antibody Type
Recombinant Antibody
Application
Isotype Control (IsoC), In vivo Studies (in vivo)
Grade
In vivo Grade
Isotype
IgG2
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Reactivity
- Human
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Host
- Human
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Expression System
- Mammalian cells
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Purpose
- In Vivo Grade Recombinant Human IgG2 Fc Protein
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Characteristics
- Human Fc (IgG2) is the tail region of an immunoglobulin G2 (IgG2) that interacts with cell surface receptors called Fc receptors and some proteins of the complement system. The ~230 amino acid fragment generally exists as a dimer, although under reducing conditions, it exists as a monomer. It is the basis of prolonged pharmacokinetics of antibodies and is commonly used as a fusion to extend half-life of fusion proteins. IgG2 has a shorter hinge than IgG1, with 12 amino acid residues and four disulfide bridges at the Fab base. The hinge region of IgG2 also lacks a glycine residue, which along with its shortness almost completely prevents rotation and restricts lateral movement of the Fabs.
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Purification
- Protein A or G affinity column
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Purity
- >95 % by SDS-PAGE under reducing conditions
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Sterility
- Sterile filtered
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Endotoxin Level
- < 1 EU per 1 mg of the protein by the LAL method
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- PBS, pH 7.4
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Storage
- 4°C,-20 °C
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Storage Comment
- 1 month from date of receipt, 2 to 8°C as supplied. 3 months from date of receipt, -20°C to -70°C as supplied.
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Expiry Date
- 3 months
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- IgG2
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Target Type
- Antibody
Target
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