Recombinant Human IgG4 Isotype Control
In vivo Grade
IsoC, in vivo
IgG4
Recombinant Antibody
unconjugated
Catalog No. ABIN7211744
Quick Overview for Recombinant Human IgG4 Isotype Control (ABIN7211744)
Target
IgG4
Antibody Type
Recombinant Antibody
Application
Isotype Control (IsoC), In vivo Studies (in vivo)
Grade
In vivo Grade
Isotype
IgG4
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Reactivity
- Human
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Host
- Human
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Expression System
- Mammalian cells
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Purpose
- In Vivo Grade Recombinant Human IgG4 Fc Protein
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Characteristics
- Human IgG4 Fc is the tail region of the immunoglobulin G4 (IgG4) that interacts with cell surface receptors called Fc receptors and some proteins of the complement system. The ~230 amino acid fragment generally exists as a dimer, although under reducing conditions, it exists as a monomer. It is the basis of prolonged pharmacokinetics of antibodies and is commonly used as a fusion to extend half-life of fusion proteins. IgG4's hinge is shorter than that of IgG1, its flexibility is intermediate between IgG1 and IgG2 and some rotation may occur around the glycine residue in its hinge region.
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Purification
- Protein A or G affinity column
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Purity
- >95 % by SDS-PAGE under reducing conditions
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Sterility
- Sterile filtered
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Endotoxin Level
- < 1 EU per 1 mg of the protein by the LAL method
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- PBS, pH 7.4
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Storage
- 4°C,-20 °C
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Storage Comment
- 1 month from date of receipt, 2 to 8°C as supplied. 3 months from date of receipt, -20°C to -70°C as supplied.
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Expiry Date
- 3 months
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- IgG4
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Target Type
- Antibody
Target
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