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Full name:: anti-Cytokine Inducible SH2-Containing Protein Antibodies (CISH)

On www.antibodies-online.com are 30 Cytokine Inducible SH2-Containing Protein (CISH) Antibodies from 10 different suppliers available. Additionally we are shipping CISH Proteins (10) and many more products for this protein. A total of 45 CISH products are currently listed.

Synonyms:: AI385595, BACTS2, Cis, CIS-1, CIS1, cish, cish.a, F17, F23, G18, ptk9l, SOCS, twf1l, wu:fk57g04, zgc:91817, zgc:154062

list all antibodies	Gene Name	GeneID	UniProt
	CISH	1154	Q9NSE2
	CISH	12700	Q62225
	CISH	83681
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anti-Rat (Rattus) CISH Antibodies:

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More Antibodies against CISH Interaction Partners

Zebrafish Cytokine Inducible SH2-Containing Protein (CISH) interaction partners

This study indicates that CISH functions as a conserved in vivo target and regulator of STAT5 (show STAT5B Antibodies) in the control of embryonic hematopoiesis.

Rainbow Trout (Oncorhynchus mykiss) Cytokine Inducible SH2-Containing Protein (CISH) interaction partners

the type II SOCS genes (CISH, SOCS1 (show SOCS1 Antibodies)-3) are particularly relevant to immune regulation in fish

Human Cytokine Inducible SH2-Containing Protein (CISH) interaction partners

CIS interacted with phosphorylated EpoR (show EPOR Antibodies) at Y401, which was critical for the activation of STAT5 (show STAT5A Antibodies) and ERK (show EPHB2 Antibodies).
Studies indicate that suppressors of cytokine signaling (SOCS) proteins CIS, SOCS1 (show SOCS1 Antibodies), and SOCS3 (show SOCS3 Antibodies) can be considered the third immunocheckpoint molecules since they regulate cytokine signals that control the polarization of CD4 (show CD4 Antibodies)(+) T cells and the maturation of CD8 (show CD8A Antibodies)(+) T cells.
CISH rs414171 and rs6768300 variants might be associated with protection from pulmonary tuberculosis in Zahedan, Southeast Iran.
This study showed that there was significantly increased levels of CIS mRNA in elderly and Alzheimer's disease brains.
Data indicate that CIS protein stability is regulated through multiple mechanisms, including ubiquitination and interaction with Elongin B (show TCEB2 Antibodies)/C proteins, whereas CIS functional inhibition of PRLR (show PRLR Antibodies) signaling is dependent on the Elongin B (show TCEB2 Antibodies)/C interaction.
SOCS single nucleotide polymorphism is associated with breast cancer.
Study in Chinese Han population confirms that previously identified variants of CISH are associated with susceptibility to pulmonary tuberculosis.
CISH gene polymorphisms at -292 (rs414171) are associated with HBV clearance in HBeAg-positive CHB patients in the immune active phase, and AA is a favorable genotype for this effect.
Two SNPs (rs414171 and rs2239751) in the CISH gene were associated with persistent HBV infection in Han Chinese population
two genetic variants in CISH gene appear to increase susceptibility to TB in Chinese Han population

Mouse (Murine) Cytokine Inducible SH2-Containing Protein (CISH) interaction partners

CIS interacted with phosphorylated EpoR (show EPOR Antibodies) at Y401, which was critical for the activation of STAT5 (show STAT5A Antibodies) and ERK (show EPHB2 Antibodies).
this study identifies CIS as a critical negative regulator of IL-15 (show IL15 Antibodies) signaling in NK cells
Data show that cytokine inducible SH2-containing protein Cish is induced upon T cell receptor stimulation and in the tumor microenvironment.
Results show that CISH has no non-redundant functions in beta cell proliferation or glucose homeostasis during pregnancy in mice. Socs2 (show SOCS2 Antibodies) might compensate for the loss of Cish during pregnancy.
CIS has a critical role in controlling the proallergic generation of helper T cells.
CISH expression at the later stage of dendritic cell development triggers the shutdown of DC progenitor cell proliferation and facilitates DC differentiation into a potent stimulator of CTLs.
CIS and SOCS3 (show SOCS3 Antibodies) play a role as negative feedback inhibitors of PRL (show PRL Antibodies) action; Inhibition of CIS and SOCS3 (show SOCS3 Antibodies) expression by glucocorticoids contributes to the positive effect of glucocorticoids on PRL (show PRL Antibodies)-induced STAT5 (show STAT5A Antibodies) activation.
Induction of CIS in response to EPO (show EPO Antibodies) stimulation depends on Stat5 (show STAT5A Antibodies) but not MAP kinase (show MAPK1 Antibodies) or PI 3 (show PI3 Antibodies)-kinase. Overexpression negatively regulates EPO (show EPO Antibodies)-mediated cell proliferation, Stat5 (show STAT5A Antibodies) phosphorylation, & activation of a Stat (show STAT1 Antibodies)-dependent luciferase reporter.
CIS negatively regulates signaling at two levels, apoptosis and proliferation, and thereby sets a threshold for signal transduction
IL-6 (show IL6 Antibodies) inhibits hepatic GH signaling by upregulating Cis and Socs-3 (show SOCS3 Antibodies), which may involve activation of STAT3 (show STAT3 Antibodies).

CISH Antigen Profile

Antigen Summary

The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with CISH

cytokine inducible SH2 containing protein (CISH) antibody
cytokine inducible SH2-containing protein (cish) antibody
cytokine inducible SH2 containing protein (cish) antibody
cytokine inducible SH2-containing protein (Cish) antibody

AI385595 antibody
BACTS2 antibody
Cis antibody
CIS-1 antibody
CIS1 antibody
cish antibody
cish.a antibody
F17 antibody
F23 antibody
G18 antibody
ptk9l antibody
SOCS antibody
twf1l antibody
wu:fk57g04 antibody
zgc:91817 antibody
zgc:154062 antibody

Protein level used designations for CISH

cytokine inducible SH2-containing protein , cytokine-inducible SH2-containing protein , cytokine inducible SH2 containing protein , cytokine inducible SH2-containing protein A , twinfilin, actin-binding protein, homolog 1, like , Cytokine-inducible SH2-containing protein , cytokine-inducible inhibitor of signaling type 1B , suppressor of cytokine signaling , CIS-1 , SOCS , cytokine-inducible SH2 protein , cytokine inducible SH2-containing protein 1 , CIS

GENE ID	SPECIES
470819	Pan troglodytes
484757	Canis lupus familiaris
701456	Macaca mulatta
767678	Danio rerio
100135018	Xenopus (Silurana) tropicalis
100144307	Takifugu rubripes
100144373	Oryzias latipes
100190868	Gasterosteus aculeatus
100196184	Salmo salar
100329195	Oncorhynchus mykiss
1154	Homo sapiens
12700	Mus musculus
83681	Rattus norvegicus
616753	Bos taurus
395335	Gallus gallus

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