Browse our anti-IFNB1 (IFNB1) Antibodies

Human Interferon, beta 1, Fibroblast (IFNB1) interaction partners

1. The overexpression of NPIPB3 restored the interferon-beta responses in severe acute respiratory syndrome coronavirus open reading frame 6 (SARS-CoV ORF6) expressing cells, indicating that the interaction of SARS CoV ORF6 and NPIPB3 reduced Type I interferon antagonism by SARS-CoV ORF6.

2. The results demonstrate that cystatin B (show CSTB Antibodies) interferes with the STAT-1 (show STAT1 Antibodies) signaling and IFN-beta-antiviral responses perpetuating HIV in macrophage reservoirs.

3. The review focuses on the value of the type I and III interferon (show IFNA Antibodies) subtypes (alphas, beta and lambdas) as therapeutics for prevention and treatment of viral infections (influenza, herpes, human immunodeficiency virus and hepatitis viruses).

4. This review briefly discusses the dysregulation of main T cell subpopulations in CNS autoimmunity and summarized the T cell targeted effects of endogenous and exogenous IFN-beta in health and EAE/MS, with emphasis on the direct actions of IFN-beta on each T cell subset involved in the disease.

5. c-Cbl (show CBL Antibodies) negatively regulates IFN-beta signaling and cellular antiviral response by promoting IRF3 (show IRF3 Antibodies) ubiquitination and degradation.

6. YPEL5 silencing enhanced the induction of IFNB1 by pattern recognition receptors and phosphorylation of TBK1 (show TBK1 Antibodies)/IKBKE (show IKBKE Antibodies) kinases, whereas co-immunoprecipitation experiments revealed that YPEL5 interacted physically with IKBKE (show IKBKE Antibodies).

7. The effect of topical TREX1 (show TREX1 Antibodies) knockdown and local interferon (show IFNA Antibodies) production on HIV transmission in human cervicovaginal explants and humanized mice, is reported.

8. this study shows that the IFN-beta/STAT1 (show STAT1 Antibodies) pathway is dysregulated in inflammatory bowel disease

9. results demonstrate that Sphingosine 1-phosphate lyase (SPL (show SGPL1 Antibodies)) is a host factor that augments type I IFN responses during influenza A virus infection; study delineates the relationship between IKKepsilon (show IKBKE Antibodies) and SPL (show SGPL1 Antibodies), which provides a mechanistic understanding of the pro-IFN activity of SPL (show SGPL1 Antibodies)

10. results suggest that, in addition to its well-known signaling activity, IFN-beta may be directly antimicrobial and be part of a growing family of cytokines and chemokines, called kinocidins, that also have antimicrobial properties.

Mouse (Murine) Interferon, beta 1, Fibroblast (IFNB1) interaction partners

1. Mycobacterium smegmatis induces higher Ifnb expression in macrophages than Mycobacterium avium subspecies.

2. In experimental autoimmune encephalomyelitis, IFN-beta inhibited downstream inflammatory cytokines through the inhibition of PI3K/AKT (show AKT1 Antibodies)/NF-kappaB (show NFKB1 Antibodies) axis and p38 (show CRK Antibodies), JNK (show MAPK8 Antibodies)-MAPK (show MAPK1 Antibodies), as well as the regulation of mTOR (show FRAP1 Antibodies) complexes. Moreover, IFN-beta inhibited Th17 differentiation and influenced the acetylation of the Il17a (show IL17A Antibodies) and Opn (show SPP1 Antibodies) gene promoters. IFN-beta plays a role in Th17 differentiation partly through the inhibition of OPN (show SPP1 Antibodies).

3. This review briefly discusses the dysregulation of main T cell subpopulations in CNS autoimmunity and summarized the T cell targeted effects of endogenous and exogenous IFN-beta in health and EAE/MS, with emphasis on the direct actions of IFN-beta on each T cell subset involved in the disease.

4. Rb selectively inhibits innate IFN-beta production by enhancing deacetylation of Ifnb1 promoter, exhibiting a previous unknown non-classical role in innate immunity, which also suggests a role of Rb in the regulation of type I IFN production in inflammatory or autoimmune diseases.

5. c-Cbl (show CBL Antibodies) negatively regulates IFN-beta signaling and cellular antiviral response by promoting IRF3 (show IRF3 Antibodies) ubiquitination and degradation.

6. The effect of topical TREX1 (show TREX1 Antibodies) knockdown and local interferon (show IFNA Antibodies) production on HIV transmission in human cervicovaginal explants and humanized mice, is reported.

7. The TBK1 (show TBK1 Antibodies) Y179A mutant failed to rescue type I IFN production by virally infected RAW264.7 macrophages deficient in TBK1 (show TBK1 Antibodies).

8. this study shows that poly I:C treated PAR-1 (show MARK2 Antibodies)-/- mice given the thrombin (show F2 Antibodies) inhibitor dabigatran etexilate exhibited less IFNbeta and CXCL10 (show CXCL10 Antibodies) expression in the spleen and plasma

9. The data demonstrate that an atypical TLR7 (show TLR7 Antibodies) signaling pathway contributes to type interferon-beta expression during Y. pestis infection and suggest that the TLR7 (show TLR7 Antibodies)-driven type I IFN response plays an important role in determining the outcome of plague.

10. Long-term exposure to atmospheric particulates, PM2.5 up-regulated H3K4 and H3K9 methylation in IL-6 (show IL6 Antibodies) and IFN-beta promoter regions through down-regulating Kdm6a (show KDM6A Antibodies) expression. The results suggest that short-term exposure to PM2.5 significantly enhances the survival rate of influenza A-contaminated mice, while long-term PM2.5 inhalation lowers the capacity of pulmonary macrophages to secrete IL-6 (show IL6 Antibodies) and IFN-beta.

Cow (Bovine) Interferon, beta 1, Fibroblast (IFNB1) interaction partners

1. BVDV2-E significantly increased IFN-beta activity compared to BVDV2-wt.

2. The data confirm the involvement of EHMT2 (show EHMT2 Antibodies) in the epigenetic regulation of IFN-b and demonstrate the activation of a general antiviral state after EHMT2 (show EHMT2 Antibodies) inhibition.

3. The authors provide evidence that ICP27 protein encoded by bovine herpesvirus type 1, a viral early protein that shuttles between the nucleus and cytoplasm inhibits transcriptional activity of two bovine IFN-beta gene promoters (IFN-beta1 and IFN-beta3).

4. The authors demonstrate that bovine herpesvirus 1 bICP0 effectively inhibits bovine IFN-beta promoter activity and induces IRF3 (show IRF3 Antibodies) degradation.

5. These studies provide evidence that virus infection differentially stimulates expression of the three bovine IFN-beta genes.

6. recombinant bovine respiratory syncytial virus lacking the NS proteins, and those lacking NS2 in particular, are strong inducers of IFN-alpha (show IFNA Antibodies)/beta in bovine nasal fibroblasts and bronchoalveolar macrophages.

Pig (Porcine) Interferon, beta 1, Fibroblast (IFNB1) interaction partners

1. Nuclear export of NSP1alpha of porcine reproductive and respiratory syndrome virus was necessary for its ability for IFN beta inhibition.

2. Porcine deltacoronavirus nsp5 (show SPECC1 Antibodies), the 3C-like protease, inhibits interferon-beta production through the cleavage of NEMO (show IKBKG Antibodies).

3. Highly pathogenic Porcine reproductive and respiratory syndrome virus modulates Interferon-beta expression mainly through attenuating IRF-3 (show IRF3 Antibodies) phosphorylation.

4. Porcine epidemic diarrhea virus nsp1 inhibited the IFN-beta and IRF3 (show IRF3 Antibodies) promoter activities.

5. poIFIT3 plays a significant role in the clearance of swine influenza virus in pigs and potentiates IFN-beta production.

6. DDX41 (show DDX41 Antibodies) is involved in the dsDNA- and dsDNA-virus-mediated type IFN-beta signaling pathway in porcine kidney cells.

7. VIral NS4 (show SOS1 Antibodies) protein antagonizes beta interferon (show IFNA Antibodies) expression by targeting the NF-kappaB (show NFKB1 Antibodies) essential modulator.

8. Swine IFN-beta promotes genetic mutation of porcine reproductive and respiratory syndrome virus.

9. Expression of LSm14A (show LSM14A Antibodies) in HEK293 or Marc (show CCL7 Antibodies)-145 cells enhanced activities of IFN-beta and NF-kappaB (show NFKB1 Antibodies) promoters, induced IFN-beta transcription, and potentiated IFN-beta promoter activation, indicating that LSm14A (show LSM14A Antibodies) is a potential signal molecule (show WNT4 Antibodies) in the IFN-beta pathway.

10. Overall, data provide evidence for the possible role of PI3K in the activation of the transcription of IFN-alpha (show IFNA Antibodies)/beta by PRRSV; study concludes that PRRSV inhibits the induction of IFN-alpha (show IFNA Antibodies) in monocyte-derived dendritic cells by as yet undefined post-transcriptional mechanisms.

Rhesus Monkey Interferon, beta 1, Fibroblast (IFNB1) interaction partners

1. either JC1 or DS1 C/EBP site is sufficient to mediate IFN beta-induced down-regulation of SIV long terminal repeat activity and virus replication in macrophages

2. Hepatitis A virus protein 2B suppresses beta interferon (show IFNA Antibodies) (IFN) gene transcription by interfering with IFN regulatory factor 3 activation.