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Human SOCS3 Protein expressed in Wheat germ - ABIN1320930
Jiang, Biswas, Steinle: Serine 307 on insulin receptor substrate 1 is required for SOCS3 and TNF-? signaling in the rMC-1 cell line. in Molecular vision 2014
we report the surprising finding that zebrafish respond to optic nerve lesion by inducing the expression of Sfpq and Socs3a
stat3 (show STAT3 Proteins)/socs3 pathway is a key response in all tissue regeneration in zebrafish.
Trpm7 (show TRPM7 Proteins) regulates exocrine pancreatic development via the Mg(2 (show MCOLN1 Proteins)+)-sensitive Socs3a pathway.
SOCS3 expression in response to trauma is unaffected by blockade of the mitogen-activated protein kinase (show MAPK1 Proteins) pathway by chemical inhibitors
The suppressor of cytokine signaling 3 gene was identified in this species, and the base sequence and deduced amino acid sequence are presented.
in homozygotes, GH signaling is reduced by the action of the SOCS1 (show SOCS1 Proteins) and SOCS3 proteins.
miR (show MLXIP Proteins)-2909 could play a vital role in prostate carcinogenesis through modulation of ISGylation system and TGFbeta (show TGFB1 Proteins) signalling via STAT1 (show STAT1 Proteins)/SOCS3.
Data show that miR (show MLXIP Proteins)-222-3p targeted SOCS3 genes and down-regulation of SOCS3 correlated with an increased expression of STAT3 (show STAT3 Proteins) activation.
increased SOCS3 in combined IL-33 (show IL33 Proteins) heterozygotes and minor allele homozygotes may be relevant for hay (show GTF2H5 Proteins) fever development
In summary, this study has shown that LIF (show LIF Proteins) is implicated in the HG-mediated inhibition of osteoblast differentiation, via promoting STAT3 (show STAT3 Proteins)/SOCS3 signaling. This study may provide insights into the signal pathway of HG-induced bone loss or delayed injured joint healing.
Data suggest that SOCS3 is an important signaling protein in CLL, and Hsp90 (show HSP90 Proteins) inhibitors represent an approach to target transcriptional repression in B cell lymphoproliferative disorders.
6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiated the inhibitory effect of IFN-alpha (show IFNA Proteins) on hepatocellular carcinoma cell proliferation through activation of the JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) signaling pathway by inhibiting SOCS3 expression.
SOCS3 was down-regulated in CML cell lines and most of BMNCs from CML patients, and the expression level of SOCS3 was associated with the inhibition of cell proliferation and drug resistance of CML cells.
SOCS3 is involved in suppression of Helicobacter pylori induced STAT3 (show STAT3 Proteins) phosphorylation by docosahexaenoic acid pretreatment.
The increased miR (show MLXIP Proteins)-203 expression is associated with the reduced anti-inflammatory mediator SOCS-3 expression and the increased endothelial adhesion molecule (show NCAM1 Proteins) expression in maternal vessel endothelium in preeclampsia.
Our results show, for the first time, that SOCS-3 regulates leptin (show LEP Proteins)-induced responses in cartilage
SOCS3 is an important negative regulator of insulin (show INS Proteins) signaling in porcine adipocytes.
Low SOCS3 expression is required for milk synthesis and proliferation of dairy cow mammary epithelial cells in vitro.
Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 (show IL10 Proteins) and SOCS-3, which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.
The strength of long bones is determined by coalescence of trabeculae during corticalization.This process is regulated by SOCS3 via a mechanism dependent on IL-6 (show IL6 Proteins) and expression of sex hormones.
High SOCS3 expression is associated with glioma.
Mechanistic analysis indicated that E47 (show TCF3 Proteins) activated expression of the transcription factor Spi-B (show SPIB Proteins) and the suppressor of cytokine signaling 3 (SOCS3), which both downregulated Foxp3 (show FOXP3 Proteins) expression. These findings demonstrate that the balance of Id3 (show ID3 Proteins) and E47 (show TCF3 Proteins) controls the maintenance of Foxp3 (show FOXP3 Proteins) expression in Treg cells and, thus, contributes to Treg cell plasticity.
Loss of suppressor of cytokine (SOCS3) expression in mature muscle fibers increased the inflammatory response to myotoxic injury but did not impair muscle regeneration in either adult or old mice. Therefore, reduced SOCS3 expression in muscle fibers is unlikely to underlie impaired muscle regeneration.
Findings revealed a novel participation of SOCS3 regulating several endocrine and metabolic aspects.
Findings indicate that inactivation of the Rb family proteins (Rb, p107 (show RBL1 Proteins), and p130) in hematopoietic stem cells (HSCs) progressively impairs their homeostasis, which is rescued upon repression of suppressor of cytokine signaling 3 protein (Socs3) expression in triple knockout (TKO (show MRPS12 Proteins)) HSCs.
Data suggest that, in B cell lymphoma, expression of MIRN30 is up-regulated in both granulocytic myeloid-derived suppressor cells and monocytic myeloid-derived suppressor cells; in B cell lymphoma, 3prime untranslated region of Socs3 appears to be direct target of MIRN30 in myeloid-derived suppressor cell differentiation. (MIRN30 = microRNA 30; Socs3 = suppressor of cytokine signaling 3 protein)
Cell type-specific, different roles for viral immediate early (show JUN Proteins) or early gene expression and/or viral tegument proteins in the early stimulation of SOCS1 (show SOCS1 Proteins) and SOCS3 during murine cytomegalovirus infection.
oncostatin M (show OSM Proteins) mitigated the proliferation of Th17 cells and decreased the expression of IL-17 (show IL17A Proteins) and IL-21 (show IL21 Proteins); it promoted the activation of suppressor of cytokine signaling 3 (SOCS3), STAT3 (show STAT3 Proteins), and STAT5 (show STAT5A Proteins); observations suggest that OSM (show OSM Proteins) can inhibit Th17 differentiation by reciprocally controlling SOCS3, STAT3 (show STAT3 Proteins), and STAT5 (show STAT5A Proteins)
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
suppressor of cytokine signaling 3
, suppressor of cytokine signaling 3a
, STAT-induced STAT inhibitor 3
, cytokine-inducible SH2 protein 3
, cytokine signaling suppressor
, E2a-Pbx1 target gene in fibroblasts 10
, cytokine inducible SH2-containing protein 3
, suppressors of cytokine signaling 3