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Human SOCS3 Protein expressed in Wheat germ - ABIN1320930
Jiang, Biswas, Steinle: Serine 307 on insulin receptor substrate 1 is required for SOCS3 and TNF-? signaling in the rMC-1 cell line. in Molecular vision 2014
we report the surprising finding that zebrafish respond to optic nerve lesion by inducing the expression of Sfpq and Socs3a
stat3 (show STAT3 Proteins)/socs3 pathway is a key response in all tissue regeneration in zebrafish.
Trpm7 (show TRPM7 Proteins) regulates exocrine pancreatic development via the Mg(2 (show MCOLN1 Proteins)+)-sensitive Socs3a pathway.
SOCS3 expression in response to trauma is unaffected by blockade of the mitogen-activated protein kinase (show MAPK1 Proteins) pathway by chemical inhibitors
The suppressor of cytokine signaling 3 gene was identified in this species, and the base sequence and deduced amino acid sequence are presented.
in homozygotes, GH signaling is reduced by the action of the SOCS1 (show SOCS1 Proteins) and SOCS3 proteins.
SOCS3 overexpression decreased JAK (show JAK3 Proteins)-STAT3 (show STAT3 Proteins) signaling pathway activity, declined Bcl-2 (show BCL2 Proteins) expression, inhibited cell proliferation, elevated cell apoptosis, and enhanced Adriamycin sensitivity in T24 cells
miR203 expression may be upregulated by IL17 (show IL17A Proteins) stimulation, and miR203 is a positive regulator of IL17induced VEGF (show VEGFA Proteins) secretion.
SOCS3 DNA methylation (show HELLS Proteins) is associated with body weight and moderates the effect of cumulative stress on obesity.
SOCS3 was targeted by miR30a- 5p in allergic rhinitis
Cellular viability was significantly decreased, whereas IL6 (show IL6 Proteins) and TNFalpha (show TNF Proteins) levels were significantly increased, following High Glucose stimulation of A549 cells. In addition, the protein levels of SOCS3, pJAK2 and pSTAT3 were significantly increased in High Glucosetreated cells.
this study shows that Nrf2 (show GABPA Proteins) activation induces lipocyte phenotype in hepatic stellate cells via enhancing SOCS3-dependent feedback inhibition on JAK2 (show JAK2 Proteins)/STAT3 (show STAT3 Proteins) cascade
SOCS-1 (show SOCS1 Proteins), SOCS-2 (show SOCS2 Proteins), and SOCS-3 proteins may directly or indirectly, have important roles in development and pathogenesis of papillary thyroid cancer
Our study showed that the expressions of HER2 (show ERBB2 Proteins), STAT3 (show STAT3 Proteins), and SOCS3 are associated with the progression of ovarian cancer (OC), and higher expressions of HER2 (show ERBB2 Proteins) and STAT3 (show STAT3 Proteins) and lower expression of SOCS3 predict poor prognosis of OC.
Authors found that SOCS3 and SOCS1 (show SOCS1 Proteins) expression was reduced in vivo, in tumor lesions of BCC and SCC (show CYP11A1 Proteins), as compared to other skin inflammatory conditions such as psoriasis, despite the high number of IL-22 (show IL22 Proteins)-secreting TILs.
the presence of SOCS3 methylation is a marker to predict treatment response and prognosis in HCC (show FAM126A Proteins) patients receiving TACE (show ADAM17 Proteins) therapy.
In porcine circovirus type 2 subclinical infection, SOCS3 interacted with STAT3 (show STAT3 Proteins) and TNF receptor-associated factor 2 (show TRAF2 Proteins), suggesting mechanisms by which SOCS3 inhibits IL-6 (show IL6 Proteins) and TNF-alpha (show TNF Proteins) signaling.
SOCS3 is an important negative regulator of insulin (show INS Proteins) signaling in porcine adipocytes.
Low SOCS3 expression is required for milk synthesis and proliferation of dairy cow mammary epithelial cells in vitro.
Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 (show IL10 Proteins) and SOCS-3, which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.
Lentivirusmediated overexpression of SOCS3 was revealed to ameliorate neutrophilic airway inflammation by inhibiting pulmonary Th17 responses in mice with chronic Pseudomonas aeruginosa lung infections.
These data demonstrate that loss of SOCS3 in cardiomyocytes promotes deoxycorticosterone-acetate -salt-induced cardiac remodeling and inflammation.
In the present study, we investigated the hypothesis that SOCS3 expression in the VMH could exert an important role regulating the metabolic changes typically observed during pregnancy and lactation.
SOCS3 was upregulated in lung CD4 (show CD4 Proteins)+ T cells in a mouse model of chronic PA lung infection and exogenous SOCS3 suppressed Th17-mediated neutrophil recruitment in vitro.
findings show SOCS3 does not appear to mediate the early inflammatory or leucine-induced changes in protein synthesis in skeletal muscle
The strength of long bones is determined by coalescence of trabeculae during corticalization.This process is regulated by SOCS3 via a mechanism dependent on IL-6 (show IL6 Proteins) and expression of sex hormones.
High SOCS3 expression is associated with glioma.
Mechanistic analysis indicated that E47 (show TCF3 Proteins) activated expression of the transcription factor Spi-B (show SPIB Proteins) and the suppressor of cytokine signaling 3 (SOCS3), which both downregulated Foxp3 (show FOXP3 Proteins) expression. These findings demonstrate that the balance of Id3 (show ID3 Proteins) and E47 (show TCF3 Proteins) controls the maintenance of Foxp3 (show FOXP3 Proteins) expression in Treg cells and, thus, contributes to Treg cell plasticity.
Our results show, for the first time, that SOCS-3 regulates leptin (show LEP Proteins)-induced responses in cartilage
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
suppressor of cytokine signaling 3
, suppressor of cytokine signaling 3a
, STAT-induced STAT inhibitor 3
, cytokine-inducible SH2 protein 3
, cytokine signaling suppressor
, E2a-Pbx1 target gene in fibroblasts 10
, cytokine inducible SH2-containing protein 3
, suppressors of cytokine signaling 3