Browse our anti-STAT3 (STAT3) Antibodies

Mouse (Murine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

1. TRYP improves the health condition of mice with DSS (show PMP22 Antibodies) induced colitis by regulating the TNF-&alpha (show TNF Antibodies);/NF-κBp65 and IL-6 (show IL6 Antibodies)/STAT3 signaling pathways via inhibiting the degradation of IκBα and the phosphorylation of STAT3.

2. Stat3 role in a regulatory module in inflammatory signaling.

3. Data identify a novel role for phospholipid phosphate phosphatase type 1 activity and hepatocyte lysophosphatidic acid levels in glucagon (show GCG Antibodies) sensitivity via a mechanism involving STAT3.

4. MicroRNA-125a-5p mediates preadipocyte proliferation and differentiation by negatively regulating STAT3.

5. Blockade of JAK1 (show JAK1 Antibodies)-JAK3 (show JAK3 Antibodies) accelerated, and selective inactivation of STAT3 decelerated differentiation of progenitor cells.

6. KMT1A (show SUV39H1 Antibodies) positively regulated the self-renewal and tumorigenicity of human Bladder cancer stem cells via KMT1A (show SUV39H1 Antibodies)-GATA3 (show GATA3 Antibodies)-STAT3 circuit, in which KMT1A (show SUV39H1 Antibodies) could be a promising target for bladder cancer therapy.

7. these findings suggest that the endothelial STAT3 signaling plays an important role in limiting kidney dysfunction in ischemic acute kidney injury

8. The result also reveals that Stat3 may be a crucial link between the induction of the four factors and the cell remodeling, suggesting its potential role as a target to fight melanoma.

9. Treatment with nifuroxazide inhibited the activation of STAT3, resulting in the regulation of the CD4 (show CD4 Antibodies)+ T cells and CD4 (show CD4 Antibodies)+CD25 (show IL2RA Antibodies)+ T cells and reduction of interferongamma and tumor necrosis factora levels

10. STAT3 restrained cytotoxic gene expression in CD8 (show CD8A Antibodies)+ T cells responding to viral infection in vivo.

Human Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

1. STAT3 signaling is hyperactivated in systemic sclerosis in a TGFbeta (show TGFB1 Antibodies)-dependent manner

2. Structural characterization of STAT3 for the purpose of development of anticancer therapies has been reported. (Review)

3. High stat3 expression is associated with Prostate Cancer.

4. STAT3 activation via Tyr705 phosphorylation plays role in he tumor-associated macrophage polarization.

5. The expression level of Sox4 correlates with HCC development, clinical severity and prognosis of patients. LncSox4 interacts with and recruits Stat3 to the Sox4 promoter to initiate the expression of Sox4, which is highly expressed in liver tumor-initiating cells (TICs) and required for liver TIC self-renewal.

6. In summary, CAPE attenuates Nasopharyngeal carcinoma (NPC (show NPC1 Antibodies))cell proliferation and invasion by upregulating NDRG1 (show NDRG1 Antibodies) expression via MAPK (show MAPK1 Antibodies) pathway and by inhibiting phosphorylation of STAT3. Considering the poor prognosis of NPC (show NPC1 Antibodies) patients with metastasis, CAPE could be a promising agent against NPC (show NPC1 Antibodies).

7. PBX1 (show PBX1 Antibodies) plays an oncogenic role in clear cell renal carcinoma (show TSC2 Antibodies) via JAK2 (show JAK2 Antibodies)/STAT3 pathway

8. the activation of STAT3, a major tumourigenic IL-6 (show IL6 Antibodies) effector, was examined in adipose-derived stem cells conditioned medium treated endometrial cancer cells.

9. ERRalpha (show ESRRA Antibodies) suppression inhibited signal transducer and activator of transcription (show STAT1 Antibodies) (STAT3) protein expression.

10. in oral tumor cells, overexpression of cyclin D1 (show CCND1 Antibodies) occurs through the activation of STAT3 and the deregulation of degradation pathway of cyclin D1 (show CCND1 Antibodies) which may favors maintaining its accumulated level in cells. It also demonstrated that cyclin D1 (show CCND1 Antibodies) expression can be controlled by targeting the STAT3 with its siRNA.

Cow (Bovine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

1. variations in the STAT3 gene promoter regions, most notably haplotype H3H3, may benefit marker-assisted breeding of Qinchuan cattle.

2. Thus, activation of STAT3 and inactivation of AKT (show AKT1 Antibodies) signaling are involved in structural regression of the corpus luteum.

3. STA3 (show ARHGEF3 Antibodies) facilitates TLR4 (show TLR4 Antibodies)-dependent IL-6 (show IL6 Antibodies) and IL-8 (show IL8 Antibodies) production via IL-6 (show IL6 Antibodies) receptor-positive feedback in endometrial cells.

4. STAT3 might have potential effects on production traits in beef cattle populations and could be used for marker-assisted selection.

5. Single-SNP analysis revealed a statistically significant association between SNP25402 in STAT3 and fertilization rate

6. results show for the first time that interleukin-6 (show IL6 Antibodies) (IL), in the presence of its soluble receptor (show IFNAR1 Antibodies) (sIL (show STIL Antibodies)-6R), induces activation of JAK1 (show JAK1 Antibodies), JAK2 (show JAK2 Antibodies), and STAT1 (show STAT1 Antibodies)/STAT3 proteins in bovine articular chondrocytes

7. peroxynitrite causes increased expression of VEGF (show VEGFA Antibodies) in vascular endothelial cells by a process that requires the activation of STAT3

8. Simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase (show NOX1 Antibodies)-mediated activation of STAT3.

Pig (Porcine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

1. STAT3tyr705 phosphorylation/total STAT3 protein at early reperfusion significantly increased by ischemic preconditioning

2. In porcine circovirus type 2 subclinical infection, SOCS3 (show SOCS3 Antibodies) interacted with STAT3 and TNF receptor-associated factor 2 (show TRAF2 Antibodies), suggesting mechanisms by which SOCS3 (show SOCS3 Antibodies) inhibits IL-6 (show IL6 Antibodies) and TNF-alpha (show TNF Antibodies) signaling.

3. this study shows that weaning caused severe inflammation associated with activation of the STAT3 pathway in the jejunum of piglets

4. maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 (show CCND2 Antibodies) and PSEN1 (show PSEN1 Antibodies) genes via a STAT3-dependent pathway

5. Studied effect of recombinant porcine leukemia inhibitory factor (show LIF Antibodies) on in vitro maturation of porcine oocytes; p-STAT3 markedly increased in both cumulus cells and oocytes cultured in pLIF (show FTH1 Antibodies)-supplemented media.

6. Data suggest that IL-6 (interleukin 6 (show IL6 Antibodies)) prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst/embryo viability through IL-6 (show IL6 Antibodies)/STAT3 signaling pathway (including up-regulation of STAT3 expression and phosphorylation).

7. the distribution of tyrosine phosphorylated signal transducer and activator of transcription 3.

8. Mitochondrial STAT3 activation has a causal role in mediating ischemic postconditioning cardioprotection through better mitochondrial function.

9. STAT3 is likely altering mitochondrial function via transcriptional regulation or indirect signaling pathways

10. Nuclear translocation of activated STAT3 and binding to STAT3 consensus DNA sequence were increased in the atrial fibrillation (AF) group.

Rabbit Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

1. Osteoarthritis-cartilage injuries are caused by activating JAK2 (show JAK2 Antibodies)/STAT3 pathway.

2. This is the first report of the genetic polymorphisms of the JAK1 (show JAK1 Antibodies) and STAT3 genes and their associations with the incidence of non-specific digestive disorder in rabbits.

Guinea Pig Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

1. Studied the role of T help 17 cells (Th17) and STAT3-VEGF (show VEGFA Antibodies) pathway in pathogenesis of psoriasis.

2. Activation of Stat3 signaling pathway may be involved in up-modulating the expression of MMP-2 (show MMP2 Antibodies) in guinea pig sclera fibroblasts, and not affect integrinbeta(1) expression.

Zebrafish Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

1. Stat3 regulates cell proliferation and axis extension in part via upregulation of Cdc25a (show CDC25A Antibodies) expression during oogenesis. Accordingly, restoring Cdc25a (show CDC25A Antibodies) expression in stat3 mutants partially suppressed cell proliferation and gastrulation defects.

2. PTPN9 (show PTPN9 Antibodies) plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 (show GATA1 Antibodies) and ZBP-89 (show ZNF148 Antibodies).

3. Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.

4. Transgenic Stat3 inhibition in cardiomyocytes restricted injury-induced proliferation and regeneration, but did not reduce cardiogenesis during animal growth.

5. This study demonistrated that Stat3 is necessary for the maximal number of Muller glia to proliferate during regeneration of the damaged zebrafish retina.

6. The results of this study suggested that the stat3/socs3 (show SOCS3 Antibodies) pathway is a key response in all tissue regeneration in zebrafish.

7. stat3, a known oncogene (show RAB1A Antibodies) and a target of ss-catenin in multiple tissues, is upregulated in apc mutant zebrafish embryos.

8. Cells undergoing convergence and extension movement may sense the gradient of signaling molecules, which are expressed in gastrula organizer by STAT3 and activate PCP (show PRCP Antibodies) in neighboring cells during zebrafish gastrulation.