Browse our anti-STAT3 (STAT3) Antibodies

Mouse (Murine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

1. BATF2 activates DUSP2 gene expression and up-regulates NF-kappaB activity via phospho-STAT3 dephosphorylation

2. These findings imply that regionally distinct patterns of STAT3 phosphorylation in the Sertoli cells depend on either location or spermatogenic activity in normal healthy testes in vivo, highlighting a novel entry point to understanding STAT signaling in mammalian spermatogenesis.

3. this study demonstrates a previously unrecognized protective role of myeloid cell-specific STAT3 signaling in immune cell-mediated skin fibrosis

4. Studied effect of Papaver nudicaule extract on reduction of inflammation through inactivating NF-kappaB and signal transducer and activator of transcription 3 (STAT3) in lipopolysaccharide treated RAW264.7 cells.

5. Study provides evidence that Stat3 activity is required for HC11 mammary epithelial cell differentiation.

6. PRMT1 thus regulates Th17 differentiation by controlling the reciprocal recruitment of STAT3 and STAT5.

7. Findings indicate excess signal transducer and activator of transcription 3 (STAT3) activity negatively regulated preproopiomelanocortin (POMC) expression in hypothalamus of diet induced obesity (DIO) mice.

8. Results indicate that dopamine receptor D5 (DRD5)-signalling in dendritic cells (DCs) was mediated through the attenuation of signal transducer and activator of transcription 3 (STAT3)-activation.

9. Study identified Fam3a, a cytokine-like protein, as a major Stat3 downstream effector in muscle stem cells and demonstrated that Fam3a is required for muscle stem cell commitment and skeletal muscle development. These findings indicate that Fam3a is a Stat3-regulated secreted factor that promotes muscle stem cell oxidative metabolism and differentiation.

10. miR-151-3p inhibited lipopolysaccharide-induced IL-6 production by targeting Stat3.

11. DLX3 is a critical regulator of STAT3 signaling network that maintains skin homeostasis.

12. Stat3 conditional knockout adult mice were significantly resistant to collagen-induced arthritis.

13. STAT3 inhibition caused significant reduction of tumor burden as well as liver-associated myeloid-derived suppressor cells (L-MDSC) due to decrease in pSTAT3 levels. STAT3 inhibition activated apoptotic signaling pathways in L-MDSC, upregulating pro-apoptotic proteins and FAS, while down-regulating Bcl-2 and pro-survival proteins. This is a previously unrecognized link between STAT3 inhibition and MDSC FAS apoptosis.

14. FLLL32, a small molecule inhibitor of JAK2/STAT3 signaling, reduces neurofibroma growth in mice.

15. These data underscore a critical sex-specific role for epithelial Stat3 signaling in K-ras mutant Lung adenocarcinomas.

16. The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators.

17. Promoter regions of ZO-1 and SOCS3 were directly regulated by transcriptional activation of STAT3. These findings suggest that regulation of the STAT3 pathway is essential for corneal endothelial homeostasis via barrier function and may protect from various inflammatory factors.

18. Denervation-activated fibro-adipogenic progenitors exhibited persistent STAT3 activation and secreted elevated levels of IL-6, which promoted muscle atrophy and fibrosis.

19. B-cell-specific STAT3 deficiency: Insight into the molecular basis of autosomal-dominant hyper-IgE syndrome.

20. the absence of epithelial Stat3 in mice leads to delayed incisor amelogenesis.

Human Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

1. There is a strong link between pri-miR-124-1 rs531564 and STAT3 rs1053023 and gastric cancer that may be pathogenic, and so worthy of further investigation.

2. A significant increase was observed in expression of STAT3 and lnc-DC genes but not SOCS1 in coronary artery disease \+ versus coronary artery disease- patients.

3. Study shows that high expression of IL22RA1 is associated with poor prognosis in pancreatic cancer. IL22 promotes pancreatic cancer stemness via IL22RA1/STAT3 signaling, identifying the mechanism of regulation of cancer stem cells by microenvironmental factors. Moreover, STAT3 activation is indispensable for the maintenance of IL22RA1-hi cells, both in the absence or presence of IL22.

4. these data indicate that miR-124 suppresses the growth and invasion of breast cancer cells via downregulation of STAT3 expression.

5. We further demonstrate that RIP4-activated STAT3 binds CCL20 promoter region and regulates its expression.

6. In extranodal NK/T-cell lymphoma, STAT3 activation correlated significantly with PD-L1 expression.

7. IFN-beta, by virtue of its activating the IDO/Kyn/AhR cascade and serine phosphorylation of STAT3, induces dormancy of melanoma tumor-repopulating cells

8. Study that STAT3 expression is regulated in colorectal neoplasm by PTPN4 which directly dephosphorylates pSTAT3 at the Tyr705 residue and suppresses its transcriptional activity.

9. SOCS3 overexpression rescued the IL-9-induced effects. Altogether, IL-9 participates in the pathogenesis of Ulcerative colitis (UC) through STAT3/SOCS3 signaling pathway and has the potential to serve as a possible therapeutic candidate in patients with UC

10. LncRNA PTCSC3 was low-expressed in anaplastic thyroid cancer (ATC) tissues and cells. Over-expressed PTCSC3 inhibited the drug resistance of ATC to doxorubicin. PTCSC3 negatively regulated STAT3, and STAT3 promoted expression of INO80. PTCSC3 regulated INO80 through STAT3. PTCSC3 suppressed stem cells properties and drug resistance of ATC to doxorubicin.

11. STAT3 is not only a downstream effector of sorafenib, but also a key regulator of cellular sensitivity to sorafenib induced cell death

12. SHP2 associates with nuclear localization of STAT3: significance in progression and prognosis of colorectal cancer

13. The association between STAT3 single nucleotide polymorphism rs4796793 and susceptibility to lung cancer in Chinese lung cancer patients.

14. Description of the role of inherited STAT1 and STAT3 mutations in the setting of human disease with highly variable phenotypes that include immunodeficiency, malignancy, and autoimmunity (review).

15. a second tyrosine phosphorylation within the SH2 domain at position Y640, induced by Tyk2, negatively controls STAT3 activity.

16. reveals a new role of mitochondrial Stat3 in preventing ASK1/p38(MAPK)-mediated apoptosis.

17. a crucial role of STAT3 in regulating the epigenetic status of T cells in Latent autoimmune diabetes of adults (LADA).

18. In the hypopharyngeal squamous cell carcinoma (HSCC) samples, low AIM2 expression was closely related to lymph node metastasis and intravascular tumor thrombus and were strongly associated with poor survival. AIM2 expression was negatively correlated with pSTAT3 expression in the HSCC tissue samples, and combined analysis revealed that patients with low AIM2 and high pSTAT3 levels had the worst survival rate.

19. The present results indicate that activation of the IL-6/STAT3 pathway contributes to the pathogenesis of thromboangiitis obliterans (TAO) by regulating cellular adhesion molecules and cytoskeleton of vascular endothelial cells.

20. The molecules inhibit STAT3 by interacting with its SH2 domain.

Cow (Bovine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

1. variations in the STAT3 gene promoter regions, most notably haplotype H3H3, may benefit marker-assisted breeding of Qinchuan cattle.

2. Thus, activation of STAT3 and inactivation of AKT signaling are involved in structural regression of the corpus luteum.

3. STA3 facilitates TLR4-dependent IL-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells.

4. STAT3 might have potential effects on production traits in beef cattle populations and could be used for marker-assisted selection.

5. Single-SNP analysis revealed a statistically significant association between SNP25402 in STAT3 and fertilization rate

6. results show for the first time that interleukin-6 (IL), in the presence of its soluble receptor (sIL-6R), induces activation of JAK1, JAK2, and STAT1/STAT3 proteins in bovine articular chondrocytes

7. role of shear flow in attenuating activation in endothelial cells

8. peroxynitrite causes increased expression of VEGF in vascular endothelial cells by a process that requires the activation of STAT3

9. Simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase-mediated activation of STAT3.

Pig (Porcine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

1. STAT3tyr705 phosphorylation/total STAT3 protein at early reperfusion significantly increased by ischemic preconditioning

2. In porcine circovirus type 2 subclinical infection, SOCS3 interacted with STAT3 and TNF receptor-associated factor 2, suggesting mechanisms by which SOCS3 inhibits IL-6 and TNF-alpha signaling.

3. this study shows that weaning caused severe inflammation associated with activation of the STAT3 pathway in the jejunum of piglets

4. maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 and PSEN1 genes via a STAT3-dependent pathway

5. Studied effect of recombinant porcine leukemia inhibitory factor on in vitro maturation of porcine oocytes; p-STAT3 markedly increased in both cumulus cells and oocytes cultured in pLIF-supplemented media.

6. Data suggest that IL-6 (interleukin 6) prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst/embryo viability through IL-6/STAT3 signaling pathway (including up-regulation of STAT3 expression and phosphorylation).

7. the distribution of tyrosine phosphorylated signal transducer and activator of transcription 3.

8. Mitochondrial STAT3 activation has a causal role in mediating ischemic postconditioning cardioprotection through better mitochondrial function.

9. STAT3 is likely altering mitochondrial function via transcriptional regulation or indirect signaling pathways

10. Nuclear translocation of activated STAT3 and binding to STAT3 consensus DNA sequence were increased in the atrial fibrillation (AF) group.

Rabbit Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

1. Osteoarthritis-cartilage injuries are caused by activating JAK2/STAT3 pathway.

2. This is the first report of the genetic polymorphisms of the JAK1 and STAT3 genes and their associations with the incidence of non-specific digestive disorder in rabbits.

Guinea Pig Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

1. Studied the role of T help 17 cells (Th17) and STAT3-VEGF pathway in pathogenesis of psoriasis.

2. Activation of Stat3 signaling pathway may be involved in up-modulating the expression of MMP-2 in guinea pig sclera fibroblasts, and not affect integrinbeta(1) expression.

Zebrafish Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

1. Stat3 is required for hepatocyte cell differentiation and liver regeneration.

2. Stat3 regulates cell proliferation and axis extension in part via upregulation of Cdc25a expression during oogenesis. Accordingly, restoring Cdc25a expression in stat3 mutants partially suppressed cell proliferation and gastrulation defects.

3. PTPN9 plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 and ZBP-89.

4. Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.

5. Transgenic Stat3 inhibition in cardiomyocytes restricted injury-induced proliferation and regeneration, but did not reduce cardiogenesis during animal growth.

6. This study demonistrated that Stat3 is necessary for the maximal number of Muller glia to proliferate during regeneration of the damaged zebrafish retina.

7. The results of this study suggested that the stat3/socs3 pathway is a key response in all tissue regeneration in zebrafish.

8. stat3, a known oncogene and a target of ss-catenin in multiple tissues, is upregulated in apc mutant zebrafish embryos.

9. Cells undergoing convergence and extension movement may sense the gradient of signaling molecules, which are expressed in gastrula organizer by STAT3 and activate PCP in neighboring cells during zebrafish gastrulation.