Browse our anti-STAT3 (STAT3) Antibodies

Mouse (Murine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

1. This study demonstrates that obesity-associated inflammation and metabolic disturbances depend on interleukin-6 (show IL6 Antibodies)/Stat3-dependent formation of a distinct natural killer population, which may provide a target for the treatment of obesity, metaflammation-associated pathologies, and diabetes.

2. These results indicate that TRPV1 (show TRPV1 Antibodies) is important for activating proinflammatory STAT3 signaling and thermoregulation-associated brain pathways in the brain.

3. we investigated the role of alisol F and 25-anhydroalisol F in mediating mitogen-activated protein kinases (MAPKs), signal transducers, and activators of transcription 3 (STAT3) and nuclear factor kappaB (NF-kappaB (show NFKB1 Antibodies)) pathways involved in the inflammation process of LPS (show TLR4 Antibodies)-stimulated RAW 264.7 cells.

4. loss of FAK (show PTK2 Antibodies) signaling during endoplasmic reticulum stress causes mitochondrial dysfunction by reducing the protective effects of mitochondrial STAT3, leading to endothelial cell death.

5. Deletion of Stat3 in the mammary glands of MMTV-Myc (show MYC Antibodies) mice resulted in increased and earlier breast hyperplasia and expedited tumorigenesis.

6. alpha7nAChR stimulation reduced neuroinflammation via activation of the JAK2 (show JAK2 Antibodies)-STAT3 pathway, thereby ameliorating the short- and long-term sequelae after intracerebral hemorrhage .

7. Taken together, the results of our present study indicated that DHCE could inhibit cellular proliferation and induce cell apoptosis in myeloma cells mediated through different mechanisms, possibly through inhibiting the IL-6/STAT3 and ERK1/2 pathways. And it may provide a new therapeutic option for MM patients.

8. activation of oligodendroglial Stat3 is required for efficient remyelination

9. Suggest that the IL-17A (show IL17A Antibodies)/IL-10 (show IL10 Antibodies)/STAT3 signaling pathway plays a crucial role in the pathogenesis of hepatic fibrosis by suppressing hepatocellular autophagy and that blocking this pathway may provide therapeutic benefits for the treatment of hepatic fibrosis.

10. ginsenoside Rb2 (show RBL2 Antibodies) inhibits osteoclast differentiation by blocking NF-kappaB (show NFKB1 Antibodies) and STAT3 signaling pathways.

Human Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

1. Tissue microarray immunostaining indicated active STAT3 signaling in human osteosarcoma, consistent with the observations in tumor extracellular vesicle (EV)-educated mesenchymal stem cells -treated mice

2. Overexpression of CXCR4 (show CXCR4 Antibodies) facilitated tumor growth and angiogenesis in SGC7901 xenograft tumors, which was associated with increased levels of phospho-STAT3. CXCR4 (show CXCR4 Antibodies) contributes to tumor angiogenesis in gastric cancer by inducing STAT3-dependent VEGF (show VEGFA Antibodies) expression.

3. The interaction between ganlyrin and SHP-1 (show PTPN6 Antibodies) leads to inhibition of STAT3 activation and to enhancement of TNF-alpha (show TNF Antibodies) and IL-17 (show IL17A Antibodies) in inflammatory cells.

4. Results suggest that mTOR (show FRAP1 Antibodies)-STAT3-HK2 (show HK2 Antibodies) pathway is involved in the glycolysis of HCC (show FAM126A Antibodies) cells and STAT3 may regulate HCC (show FAM126A Antibodies) glycolysis through HK2 (show HK2 Antibodies) pathway.

5. Inhibition of drug resistance by apigenin is related to the suppression of the signal transducer and activator of transcription 3 (STAT3) signaling pathway

6. This study demonstrates that obesity-associated inflammation and metabolic disturbances depend on interleukin-6 (show IL6 Antibodies)/Stat3-dependent formation of a distinct natural killer population, which may provide a target for the treatment of obesity, metaflammation-associated pathologies, and diabetes.

7. Our study showed that the expressions of HER2 (show ERBB2 Antibodies), STAT3, and SOCS3 (show SOCS3 Antibodies) are associated with the progression of ovarian cancer (OC), and higher expressions of HER2 (show ERBB2 Antibodies) and STAT3 and lower expression of SOCS3 (show SOCS3 Antibodies) predict poor prognosis of OC.

8. Molecular modelling studies of PAK1 (show PAK1 Antibodies) with its major interacting partners RHOA (show RHOA Antibodies) and STAT3 revealed potential network gene elements in breast invasive carcinoma.

9. Our finding supports that STAT3 was the potential treated target for breast cancer therapy, whereas STAT5A (show STAT5A Antibodies)/5B/6 were potential prognostic markers for better survival of BC, providing more accurate prognosis.

10. Calcitriol treatment of the TL-1 (show TNFSF15 Antibodies) cell line (model of T-LGLL) led to decreased phospho-Y701 STAT1 (show STAT1 Antibodies) and phospho-Y705 STAT3 and increased vitamin D receptor (VDR) levels.

Cow (Bovine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

1. Thus, activation of STAT3 and inactivation of AKT (show AKT1 Antibodies) signaling are involved in structural regression of the corpus luteum.

2. STA3 (show ARHGEF3 Antibodies) facilitates TLR4 (show TLR4 Antibodies)-dependent IL-6 (show IL6 Antibodies) and IL-8 (show IL8 Antibodies) production via IL-6 (show IL6 Antibodies) receptor-positive feedback in endometrial cells.

3. STAT3 might have potential effects on production traits in beef cattle populations and could be used for marker-assisted selection.

4. Single-SNP analysis revealed a statistically significant association between SNP25402 in STAT3 and fertilization rate

5. results show for the first time that interleukin-6 (show IL6 Antibodies) (IL), in the presence of its soluble receptor (show IFNAR1 Antibodies) (sIL (show STIL Antibodies)-6R), induces activation of JAK1 (show JAK1 Antibodies), JAK2 (show JAK2 Antibodies), and STAT1 (show STAT1 Antibodies)/STAT3 proteins in bovine articular chondrocytes

6. peroxynitrite causes increased expression of VEGF (show VEGFA Antibodies) in vascular endothelial cells by a process that requires the activation of STAT3

7. Simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase (show NOX1 Antibodies)-mediated activation of STAT3.

Pig (Porcine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

1. this study shows that weaning caused severe inflammation associated with activation of the STAT3 pathway in the jejunum of piglets

2. maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 (show CCND2 Antibodies) and PSEN1 (show PSEN1 Antibodies) genes via a STAT3-dependent pathway

3. Studied effect of recombinant porcine leukemia inhibitory factor (show LIF Antibodies) on in vitro maturation of porcine oocytes; p-STAT3 markedly increased in both cumulus cells and oocytes cultured in pLIF (show FTH1 Antibodies)-supplemented media.

4. Data suggest that IL-6 (interleukin 6 (show IL6 Antibodies)) prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst/embryo viability through IL-6 (show IL6 Antibodies)/STAT3 signaling pathway (including up-regulation of STAT3 expression and phosphorylation).

5. the distribution of tyrosine phosphorylated signal transducer and activator of transcription 3.

6. Mitochondrial STAT3 activation has a causal role in mediating ischemic postconditioning cardioprotection through better mitochondrial function.

7. STAT3 is likely altering mitochondrial function via transcriptional regulation or indirect signaling pathways

8. Nuclear translocation of activated STAT3 and binding to STAT3 consensus DNA sequence were increased in the atrial fibrillation (AF) group.

Rabbit Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

1. This is the first report of the genetic polymorphisms of the JAK1 (show JAK1 Antibodies) and STAT3 genes and their associations with the incidence of non-specific digestive disorder in rabbits.

Guinea Pig Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

1. Studied the role of T help 17 cells (Th17) and STAT3-VEGF (show VEGFA Antibodies) pathway in pathogenesis of psoriasis.

2. Activation of Stat3 signaling pathway may be involved in up-modulating the expression of MMP-2 (show MMP2 Antibodies) in guinea pig sclera fibroblasts, and not affect integrinbeta(1) expression.

Zebrafish Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

1. Stat3 regulates cell proliferation and axis extension in part via upregulation of Cdc25a (show CDC25A Antibodies) expression during oogenesis. Accordingly, restoring Cdc25a (show CDC25A Antibodies) expression in stat3 mutants partially suppressed cell proliferation and gastrulation defects.

2. PTPN9 (show PTPN9 Antibodies) plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 (show GATA1 Antibodies) and ZBP-89 (show ZNF148 Antibodies).

3. Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.

4. Transgenic Stat3 inhibition in cardiomyocytes restricted injury-induced proliferation and regeneration, but did not reduce cardiogenesis during animal growth.

5. This study demonistrated that Stat3 is necessary for the maximal number of Muller glia to proliferate during regeneration of the damaged zebrafish retina.

6. The results of this study suggested that the stat3/socs3 (show SOCS3 Antibodies) pathway is a key response in all tissue regeneration in zebrafish.

7. stat3, a known oncogene (show RAB1A Antibodies) and a target of ss-catenin in multiple tissues, is upregulated in apc mutant zebrafish embryos.

8. Cells undergoing convergence and extension movement may sense the gradient of signaling molecules, which are expressed in gastrula organizer by STAT3 and activate PCP (show PRCP Antibodies) in neighboring cells during zebrafish gastrulation.