Browse our anti-STAT3 (STAT3) Antibodies

Mouse (Murine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

1. These results suggest that the inhibition of IL6 (show IL6 Antibodies)/STAT3 signaling is a potential mechanism by which PZH is used in the treatment of ulcerative colitis.

2. these data showed that CK induced ERS and apoptosis by inhibiting p-STAT3 in human liver cancer cells; thus, CK might be a potential therapeutic candidate for human HCC (show FAM126A Antibodies).

3. Study showed that Mig-6 has an important function of tumor s (show ERRFI1 Antibodies)uppressor via inhibition of STAT3 phosphorylation in uterine epithelial cells, and the antitumor effects of progesterone are mediated by the endometrial stroma.

4. results suggest that IL-6 (show IL6 Antibodies) gene requires up-regulation of phospho-JAK2 (show JAK2 Antibodies)/STAT3, PACAP (show ADCYAP1 Antibodies), and PAC1R (show ADCYAP1R1 Antibodies) and down-regulation of the TNF-alpha (show TNF Antibodies) gene to modulate its anticonvulsive/neuroprotective potential

5. IL-33 (show IL33 Antibodies) may down-regulate CLDN1 (show CLDN1 Antibodies) expression through the ERK (show EPHB2 Antibodies)/STAT3 pathway in keratinocytes.

6. ephrin type-B receptor 1 (EphB1 (show EPHB1 Antibodies)) is upregulated in injured motor neurons, which in turn can activate astrocytes through ephrin-B1 (show EFNB1 Antibodies)-mediated stimulation of signal transducer and activator of transcription-3 (STAT3)

7. TRYP improves the health condition of mice with DSS (show PMP22 Antibodies) induced colitis by regulating the TNF-&alpha (show TNF Antibodies);/NF-κBp65 and IL-6 (show IL6 Antibodies)/STAT3 signaling pathways via inhibiting the degradation of IκBα and the phosphorylation of STAT3.

8. Stat3 role in a regulatory module in inflammatory signaling.

9. Data identify a novel role for phospholipid phosphate phosphatase type 1 activity and hepatocyte lysophosphatidic acid levels in glucagon (show GCG Antibodies) sensitivity via a mechanism involving STAT3.

10. MicroRNA-125a-5p mediates preadipocyte proliferation and differentiation by negatively regulating STAT3.

Human Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

1. High STAT3 expression is associated with drug resistance in Chronic myeloid leukemia (show BCL11A Antibodies).

2. Case Report: breast implant-associated anaplastic large cell lymphoma with dual JAK1 (show JAK1 Antibodies)/STAT3 mutations.

3. Data indicate that signal transducer and activator of transcription 3 (STAT3) has emerged as a promising target in cancer immunotherapy [Review].

4. Downregulation of the lincRNA of the NED25 gene was associated with sepsis in patients by modulating the signaling pathways downstream of miR (show MLXIP Antibodies)-125b/STAT3/PCT (show UROD Antibodies)/NO signaling pathway.

5. High STAT3 expression is associated with invasion and lymph node metastasis in gastric cancer.

6. The present study demonstrated that the downregulation of filaggrin (show FLG Antibodies) in the epidermis by toluene is mediated by ERK1/2 and STAT3-dependent pathways.

7. these results indicated that STAT3-mediated downexpression of miR (show MLXIP Antibodies)-579-3p caused resistance to vemurafenib. Our findings suggest novel approaches to overcome resistance to vemurafenib by combining vemurafenib with STAT3 sliencing or miR (show MLXIP Antibodies)-579-3p overexpression.

8. Our study identified the STAT3 rs1053004 C/C as a high-risk genotype in MA (MISSED ABORTION) with lower survivin and VEGF (show VEGFA Antibodies) transcription levels in the peripheral blood

9. The role of mitochondrial Stat3 as regulator for lymphocyte function is reviewed.

10. addition of colivelin, a STAT3 activator, instead of IL-6 (show IL6 Antibodies) and C2C12 conditioned medium, promoted the myogenic differentiation of adipose tissue-derived stem cells.

Cow (Bovine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

1. variations in the STAT3 gene promoter regions, most notably haplotype H3H3, may benefit marker-assisted breeding of Qinchuan cattle.

2. Thus, activation of STAT3 and inactivation of AKT (show AKT1 Antibodies) signaling are involved in structural regression of the corpus luteum.

3. STA3 (show ARHGEF3 Antibodies) facilitates TLR4 (show TLR4 Antibodies)-dependent IL-6 (show IL6 Antibodies) and IL-8 (show IL8 Antibodies) production via IL-6 (show IL6 Antibodies) receptor-positive feedback in endometrial cells.

4. STAT3 might have potential effects on production traits in beef cattle populations and could be used for marker-assisted selection.

5. Single-SNP analysis revealed a statistically significant association between SNP25402 in STAT3 and fertilization rate

6. results show for the first time that interleukin-6 (show IL6 Antibodies) (IL), in the presence of its soluble receptor (show IFNAR1 Antibodies) (sIL (show STIL Antibodies)-6R), induces activation of JAK1 (show JAK1 Antibodies), JAK2 (show JAK2 Antibodies), and STAT1 (show STAT1 Antibodies)/STAT3 proteins in bovine articular chondrocytes

7. peroxynitrite causes increased expression of VEGF (show VEGFA Antibodies) in vascular endothelial cells by a process that requires the activation of STAT3

8. Simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase (show NOX1 Antibodies)-mediated activation of STAT3.

Pig (Porcine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

1. STAT3tyr705 phosphorylation/total STAT3 protein at early reperfusion significantly increased by ischemic preconditioning

2. In porcine circovirus type 2 subclinical infection, SOCS3 (show SOCS3 Antibodies) interacted with STAT3 and TNF receptor-associated factor 2 (show TRAF2 Antibodies), suggesting mechanisms by which SOCS3 (show SOCS3 Antibodies) inhibits IL-6 (show IL6 Antibodies) and TNF-alpha (show TNF Antibodies) signaling.

3. this study shows that weaning caused severe inflammation associated with activation of the STAT3 pathway in the jejunum of piglets

4. maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 (show CCND2 Antibodies) and PSEN1 (show PSEN1 Antibodies) genes via a STAT3-dependent pathway

5. Studied effect of recombinant porcine leukemia inhibitory factor (show LIF Antibodies) on in vitro maturation of porcine oocytes; p-STAT3 markedly increased in both cumulus cells and oocytes cultured in pLIF (show FTH1 Antibodies)-supplemented media.

6. Data suggest that IL-6 (interleukin 6 (show IL6 Antibodies)) prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst/embryo viability through IL-6 (show IL6 Antibodies)/STAT3 signaling pathway (including up-regulation of STAT3 expression and phosphorylation).

7. the distribution of tyrosine phosphorylated signal transducer and activator of transcription 3.

8. Mitochondrial STAT3 activation has a causal role in mediating ischemic postconditioning cardioprotection through better mitochondrial function.

9. STAT3 is likely altering mitochondrial function via transcriptional regulation or indirect signaling pathways

10. Nuclear translocation of activated STAT3 and binding to STAT3 consensus DNA sequence were increased in the atrial fibrillation (AF) group.

Rabbit Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

1. Osteoarthritis-cartilage injuries are caused by activating JAK2 (show JAK2 Antibodies)/STAT3 pathway.

2. This is the first report of the genetic polymorphisms of the JAK1 (show JAK1 Antibodies) and STAT3 genes and their associations with the incidence of non-specific digestive disorder in rabbits.

Guinea Pig Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

1. Studied the role of T help 17 cells (Th17) and STAT3-VEGF (show VEGFA Antibodies) pathway in pathogenesis of psoriasis.

2. Activation of Stat3 signaling pathway may be involved in up-modulating the expression of MMP-2 (show MMP2 Antibodies) in guinea pig sclera fibroblasts, and not affect integrinbeta(1) expression.

Zebrafish Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

1. Stat3 regulates cell proliferation and axis extension in part via upregulation of Cdc25a (show CDC25A Antibodies) expression during oogenesis. Accordingly, restoring Cdc25a (show CDC25A Antibodies) expression in stat3 mutants partially suppressed cell proliferation and gastrulation defects.

2. PTPN9 (show PTPN9 Antibodies) plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 (show GATA1 Antibodies) and ZBP-89 (show ZNF148 Antibodies).

3. Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.

4. Transgenic Stat3 inhibition in cardiomyocytes restricted injury-induced proliferation and regeneration, but did not reduce cardiogenesis during animal growth.

5. This study demonistrated that Stat3 is necessary for the maximal number of Muller glia to proliferate during regeneration of the damaged zebrafish retina.

6. The results of this study suggested that the stat3/socs3 (show SOCS3 Antibodies) pathway is a key response in all tissue regeneration in zebrafish.

7. stat3, a known oncogene (show RAB1A Antibodies) and a target of ss-catenin in multiple tissues, is upregulated in apc mutant zebrafish embryos.

8. Cells undergoing convergence and extension movement may sense the gradient of signaling molecules, which are expressed in gastrula organizer by STAT3 and activate PCP (show PRCP Antibodies) in neighboring cells during zebrafish gastrulation.