STAT3 antibody (AA 670-769)

Catalog No. ABIN563028

Cited in 1 publication. The Mouse Monoclonal anti-STAT3 antibody (Clone 4D6) (ABIN563028) specifically detects STAT3 in WB, ELISA, IF and PLA. The antibody is reactive with Human samples.

Quick Overview for STAT3 antibody (AA 670-769) (ABIN563028)

Target: STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This STAT3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Proximity Ligation Assay (PLA)

Clone: 4D6

Product Details anti-STAT3 Antibody

Binding Specificity: AA 670-769

Purpose: Mouse monoclonal antibody raised against a partial recombinant STAT3.

Sequence: LVYLYPDIPK EEAFGKYCRP ESQEHPEADP GAAPYLKTKF ICVTPTTCSN TIDLPMSPRT LDSLMQFGNN GEGAEPSAGG QFESLTFDME LTSECATSPM

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: STAT3 (NP_003141, 670 a.a. ~ 769 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-STAT3 antibody (ABIN563028)

Wang, Holloway, Ma, Cooper, Riolo, Samkari, Elenitoba-Johnson, Chin, Altura: "Acetylation directs survivin nuclear localization to repress STAT3 oncogenic activity." in: The Journal of biological chemistry, Vol. 285, Issue 46, pp. 36129-37, (2010) (PubMed).

Target Details for STAT3

Target: STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))

Alternative Name: STAT3

Background: Full Gene Name: signal transducer and activator of transcription 3 (acute-phase response factor)
Synonyms: APRF,FLJ20882,HIES,MGC16063

Gene ID: 6774

NCBI Accession: NM_003150

Pathways: JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Neurotrophin Signaling Pathway, Dopaminergic Neurogenesis, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Stem Cell Maintenance, Hepatitis C, Protein targeting to Nucleus, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor