SensoLyte® 490 MMP-9 Assay Kit

Catalog No. ABIN1882527

Quick Overview for SensoLyte® 490 MMP-9 Assay Kit (ABIN1882527)

Target: MMP 9 (MMP9) (Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) (MMP9))

Detection Method: Fluorometric

Application: Fluorescence Resonance Energy Transfer Microscopy (FRET)

Product Details

Brand: SensoLyte®

Characteristics: The SensoLyte® 490 MMP-9 Assay Kit is a complete assay system designed to continuously analyze MMP activity or to screen for MMP-9 inhibitors using a fluorogenic MMP-9 substrate. The assays are performed in a convenient 96-well or 384-well microplate format. The kit provides speed, convenience and accuracy in MMP-9 analysis.

Application Details

Comment:

FRET-based Assay Kit

Restrictions: For Research Use only

Handling

Handling Advice: Protect Components A and B from light.

Storage: -20 °C

Storage Comment: Store all components at -20 °C. Components D and E can be stored at 4 °C for convenience.

References

Won, Lee, Wali, Stein, Sayeed: "Progesterone attenuates hemorrhagic transformation after delayed tPA treatment in an experimental model of stroke in rats: involvement of the VEGF-MMP pathway." in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 34, Issue 1, pp. 72-80, (2014) (PubMed).

Mei, Li, Chu, Yiu, Lo: "The inhibitory effects of silver diamine fluoride at different concentrations on matrix metalloproteinases." in: Dental materials : official publication of the Academy of Dental Materials, Vol. 28, Issue 8, pp. 903-8, (2012) (PubMed).

Djouad, Rackwitz, Song, Janjanin, Tuan: "ERK1/2 activation induced by inflammatory cytokines compromises effective host tissue integration of engineered cartilage." in: Tissue engineering. Part A, Vol. 15, Issue 10, pp. 2825-35, (2009) (PubMed).

Oh, Kim, Ahn, Yoon, Yoo, Choi, Lee, Ryu, Min: "Syndecan-1 enhances the endometrial cancer invasion by modulating matrix metalloproteinase-9 expression through nuclear factor kappaB." in: Gynecologic oncology, Vol. 114, Issue 3, pp. 509-15, (2009) (PubMed).

Lin, Hou, Shen, Juan, Ko, Wang, Chen: "Quercetin inhibition of tumor invasion via suppressing PKC delta/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells." in: Carcinogenesis, Vol. 29, Issue 9, pp. 1807-15, (2008) (PubMed).

Target Details

Target: MMP 9 (MMP9) (Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) (MMP9))

Alternative Name: MMP-9

Background: Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated proteins capable of digesting extracellular matrix components. MMP-9 (gelatinase-B, collagenase-IV) is involved in quite a few diseases such as a cancer, angiogenesis, alopecia and metastasis.