Endothelin 1 ELISA Kit

Catalog No. ABIN5510599

This Colorimetric ELISA kit is designed for the quantitative measurement of Horse Endothelin 1.

Quick Overview for Endothelin 1 ELISA Kit (ABIN5510599)

Target: Endothelin 1 (EDN1)

Binding Specificity: AA 53-73

Reactivity: Horse

Detection Method: Colorimetric

Method Type: Sandwich ELISA

Application: ELISA

Product Details Endothelin 1 ELISA Kit

Purpose: Sandwich High Sensitivity ELISA kit for Quantitative Detection of horse equine Endothelin

Brand: PicoKine™

Analytical Method: Quantitative

Specificity: Expression system for standard: horse equine peptide
Immunogen sequence: C53-W73

Cross-Reactivity (Details): There is no detectable cross-reactivity with other relevant proteins.

Characteristics:

Sequence similarities: Belongs to the endothelin/sarafotoxin family.

Tissue Specificity: Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells. .

Application Details

Plate: Pre-coated

Restrictions: For Research Use only

Handling

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Expiry Date: 12 months

Target Details for Endothelin 1

Target: Endothelin 1 (EDN1)

Alternative Name: EDN1

Background:

Protein Function: Endothelins are endothelium-derived vasoconstrictor peptides.

Background: The endothelins is a family of structurally and pharmacologically distinct peptides, which has been identified and sequenced in humans. Three isoforms of horse equine endothelin have been identified: endothelin-1, -2, and -3. Endothelin-1 is a potent, 21-amino acid vasoconstrictor peptide produced by vascular endothelial cells. Endothelins are 21-amino acid vasoconstricting peptides produced primarily in the endothelium having a key role in vascular homeostasis. Endothelins are implicated in vascular diseases of several organ systems, including the heart, general circulation and brain. Endothelins are proteins that constrict blood vessels and raise blood pressure. They are normally kept in balance by other mechanisms, but when they are over-expressed, they contribute to high blood pressure(hypertension) and heart disease.

Synonyms: Endothelin-1,Preproendothelin-1,PPET1,Endothelin-1,ET-1,Big endothelin-1,EDN1,

Full Gene Name: Endothelin-1

Cellular Localisation: Secreted.

UniProt: P05305

Pathways: Hormone Transport, Negative Regulation of Hormone Secretion, Regulation of Systemic Arterial Blood Pressure by Hormones, cAMP Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of Cell Size