Sclerostin ELISA Kit
Quick Overview for Sclerostin ELISA Kit (ABIN5510605)
Target
See all Sclerostin (SOST) ELISA KitsBinding Specificity
Reactivity
Detection Method
Method Type
Application
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Purpose
- Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human Sclerostin/SOST
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Brand
- PicoKine™
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Analytical Method
- Quantitative
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Specificity
- Expression system for standard: NSO, Immunogen sequence: Q24-Y213
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Cross-Reactivity (Details)
- There is no detectable cross-reactivity with other relevant proteins.
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Characteristics
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Tissue Specificity: Widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteoblasts differentiated for 21 days. Detected in the subendothelial layer of the aortic intima (at protein level). .
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Sclerostin (SOST) ELISA Kit
SOST Reactivity: Human Colorimetric Sandwich ELISA 0.31 ng/mL - 20 ng/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
Sclerostin (SOST) ELISA KitSOST Reactivity: Mouse Colorimetric Sandwich ELISA 6.25 pg/mL - 400 pg/mL Plasma, Serum, Tissue Homogenate
Sclerostin (SOST) ELISA KitSOST Reactivity: Rat Colorimetric Sandwich ELISA 78 pg/mL - 5000 pg/mL Plasma, Serum, Tissue Homogenate
Sclerostin (SOST) ELISA KitSOST Reactivity: Rat Colorimetric Sandwich ELISA 31.25 pg/mL - 2000 pg/mL Cell Culture Supernatant, Plasma, Serum
Sclerostin (SOST) ELISA KitSOST Reactivity: Mouse AA 24-211 Colorimetric Sandwich ELISA 15.6-1000 pg/mL Cell Culture Supernatant, Plasma (EDTA), Plasma (heparin), Serum
Sclerostin (SOST) ELISA KitSOST Reactivity: Rat AA 29-213 Colorimetric Sandwich ELISA
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Plate
- Pre-coated
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Restrictions
- For Research Use only
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Storage
- 4 °C,-20 °C
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Storage Comment
- Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
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Expiry Date
- 12 months
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- Sclerostin (SOST)
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Alternative Name
- SOST
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Background
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Protein Function: Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. .
Background: Sclerostin is a protein that in humans is encoded by the SOST gene. It is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Additionally, Sclerostin is produced by the osteocyte and has anti-anabolic effects on bone formation. The SOST gene maps to chromosome 17q12-q21.
Synonyms: Sclerostin,SOST,UNQ2976/PRO7455/PRO7476,
Full Gene Name: Sclerostin
Cellular Localisation: Secreted, extracellular space, extracellular matrix. -
UniProt
- Q9BQB4
Target See all Sclerostin (SOST) ELISA Kits
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