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GZMB ELISA Kit

This Colorimetric ELISA kit is designed for the quantitative measurement of Mouse GZMB.

Mouse Granzyme B PicoKine ELISA Kit standard curve (GZMB ELISA Kit)

1 image

Catalog No. ABIN5510620

Quick Overview for GZMB ELISA Kit (ABIN5510620)

Target

See all GZMB ELISA Kits

GZMB (Granzyme B (GZMB))

Binding Specificity

AA 21-247

Reactivity

11
5
5
3
1
1
1
1
1
1
1
1

Mouse

Detection Method

Colorimetric

Method Type

Sandwich ELISA

Application

ELISA

Discover our top product GZMB ELISA Kit

Purpose

Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse Granzyme B

Brand

PicoKine™

Analytical Method

Quantitative

Specificity

Expression system for standard: NSO, Immunogen sequence: I21-S247

Cross-Reactivity (Details)

There is no detectable cross-reactivity with other relevant proteins.
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Granzyme B (GZMB) ELISA Kit
GZMB Reactivity: Human AA 21-247 Colorimetric Sandwich ELISA 15.6-1000 pg/mL Cell Culture Supernatant, Plasma (EDTA), Plasma (heparin), Serum

Granzyme B (GZMB) ELISA Kit
GZMB Reactivity: Human Colorimetric Sandwich ELISA 15.6 pg/mL - 1000 pg/mL Cell Culture Supernatant, Plasma (EDTA - heparin), Serum

Plate

Pre-coated

Restrictions

For Research Use only
Storage

4 °C,-20 °C

Storage Comment

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Expiry Date

12 months
Target See all GZMB ELISA Kits

GZMB (Granzyme B (GZMB))

Alternative Name

Gzmb

Background

Protein Function: This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis (By similarity). .
Background: Granzyme B is a serine protease that in humans is encoded by the GZMB gene. Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. CTL and NK cells share the remarkable ability to recognize specific infected target cells. They are thought to protect their host by inducing apoptosis of cells that bear on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.
Synonyms: Granzyme B(G,H),3.4.21.79,CTLA-1,Cytotoxic cell protease 1,CCP1,Fragmentin-2,Gzmb,Ctla-1, Ctla1,
Full Gene Name: Granzyme B(G,H)
Cellular Localisation: Cytoplasmic granule. Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.

UniProt

P04187

Pathways

Apoptosis, Caspase Cascade in Apoptosis

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