WFDC2 ELISA Kit

Catalog No. ABIN5510648

This Human WFDC2 ELISA Kit is a Colorimetric ELISA Kit designed to quantify Human WFDC2. This ELISA Kit has been cited in1 publication.

Quick Overview for WFDC2 ELISA Kit (ABIN5510648)

Target: WFDC2 (WAP Four-Disulfide Core Domain 2 (WFDC2))

Binding Specificity: AA 31-124

Reactivity: Human

Detection Method: Colorimetric

Method Type: Sandwich ELISA

Application: ELISA

Product Details WFDC2 ELISA Kit

Purpose: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human HE4

Brand: PicoKine™

Analytical Method: Quantitative

Specificity: Expression system for standard: E.coli
Immunogen sequence: E31-F124

Cross-Reactivity (Details): There is no detectable cross-reactivity with other relevant proteins.

Characteristics:

Tissue Specificity: Expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. Highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis. .

Application Details

Plate: Pre-coated

Restrictions: For Research Use only

Handling

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Expiry Date: 12 months

References for WFDC2 ELISA Kit (ABIN5510648)

Dong, Liu, Li: "Value of HE4 Combined with Cancer Antigen 125 in the Diagnosis of Endometrial Cancer." in: Pakistan journal of medical sciences, Vol. 33, Issue 4, pp. 1013-1017, (2017) (PubMed).

Target Details for WFDC2

Target: WFDC2 (WAP Four-Disulfide Core Domain 2 (WFDC2))

Alternative Name: WFDC2

Background:

Protein Function: Broad range protease inhibitor. .

Background: WAP four-disulfide core domain protein 2, also known as Human Epididymis Protein 4 (HE4), is a protein that in humans is encoded by the WFDC2 gene. This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation.

Synonyms: WAP four-disulfide core domain protein 2,Epididymal secretory protein E4,Major epididymis-specific protein E4,Putative protease inhibitor WAP5,WFDC2,HE4, WAP5,

Full Gene Name: WAP four-disulfide core domain protein 2

Cellular Localisation: Secreted.

UniProt: Q14508