R-Spondin 4 ELISA Kit

Catalog No. ABIN5510660

This Human R-Spondin 4 ELISA Kit is a Colorimetric ELISA Kit designed to quantify Human R-Spondin 4.

Quick Overview for R-Spondin 4 ELISA Kit (ABIN5510660)

Target: R-Spondin 4 (RSPO4)

Binding Specificity: AA 20-234

Reactivity: Human

Detection Method: Colorimetric

Method Type: Sandwich ELISA

Application: ELISA

Product Details R-Spondin 4 ELISA Kit

Purpose: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human R-Spondin-4

Brand: PicoKine™

Analytical Method: Quantitative

Specificity: Expression system for standard: NSO
Immunogen sequence: L20-P234

Cross-Reactivity (Details): There is no detectable cross-reactivity with other relevant proteins.

Application Details

Plate: Pre-coated

Restrictions: For Research Use only

Handling

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Expiry Date: 12 months

Target Details for R-Spondin 4

Target: R-Spondin 4 (RSPO4)

Alternative Name: RSPO4

Background:

Protein Function: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. .

Background: R-spondin 4 is a protein in humans that is encoded by the RSPO4 gene. It is mapped to chromosome 20p13. This gene encodes a member of the R-spondin family of proteins that share a common domain organization consisting of a signal peptide, cysteine-rich/furin-like domain, thrombospondin domain and a C-terminal basic region. The encoded protein may be involved in activation of Wnt/beta-catenin signaling pathways. Mutations in this gene are associated with anonychia congenital. Alternate splicing results in multiple transcript variants.

Synonyms: R-spondin-4,Roof plate-specific spondin-4,hRspo4,RSPO4,C20orf182,

Full Gene Name: R-spondin-4

Cellular Localisation: Secreted.

UniProt: Q2I0M5