Peroxiredoxin 2 ELISA Kit

Catalog No. ABIN5510694

Human Peroxiredoxin 2 ELISA Kit Colorimetric assay for quantification of Human Peroxiredoxin 2.

Quick Overview for Peroxiredoxin 2 ELISA Kit (ABIN5510694)

Target: Peroxiredoxin 2 (PRDX2)

Binding Specificity: AA 2-198

Reactivity: Human

Detection Method: Colorimetric

Method Type: Sandwich ELISA

Application: ELISA

Product Details Peroxiredoxin 2 ELISA Kit

Purpose: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human Peroxiredoxin 2

Brand: PicoKine™

Analytical Method: Quantitative

Specificity: Expression system for standard: NSO, Immunogen sequence: A2-N198

Cross-Reactivity (Details): There is no detectable cross-reactivity with other relevant proteins.

Application Details

Plate: Pre-coated

Restrictions: For Research Use only

Handling

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Expiry Date: 12 months

Target Details for Peroxiredoxin 2

Target: Peroxiredoxin 2 (PRDX2)

Alternative Name: PRDX2

Background:

Protein Function: Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).

Background: Peroxiredoxin-2 is a protein that in humans is encoded by the PRDX2 gene. This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. It may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13.

Synonyms: Peroxiredoxin-2,1.11.1.15,Natural killer cell-enhancing factor B,NKEF-B,PRP,Thiol-specific antioxidant protein,TSA,Thioredoxin peroxidase 1,Thioredoxin-dependent peroxide reductase 1,PRDX2,NKEFB, TDPX1,

Full Gene Name: Peroxiredoxin-2

Cellular Localisation: Cytoplasm.

UniProt: P32119