PRSS3 ELISA Kit

Catalog No. ABIN5510696

This Human PRSS3 ELISA Kit is a Colorimetric ELISA Kit designed to quantify Human PRSS3.

Quick Overview for PRSS3 ELISA Kit (ABIN5510696)

Target: PRSS3 (Protease, serine, 3 (PRSS3))

Binding Specificity: AA 16-247

Reactivity: Human

Detection Method: Colorimetric

Method Type: Sandwich ELISA

Application: ELISA

Product Details PRSS3 ELISA Kit

Purpose: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human Pan Trypsin

Brand: PicoKine™

Analytical Method: Quantitative

Specificity: Expression system for standard: NSO
Immunogen sequence: A16-S247

Cross-Reactivity (Details): There is no detectable cross-reactivity with other relevant proteins.

Characteristics:

Tissue Specificity: Expressed in pancreas and brain. Also expressed in Paneth cells, at the base of small intestinal crypts. .

Application Details

Plate: Pre-coated

Restrictions: For Research Use only

Handling

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Expiry Date: 12 months

Target Details for PRSS3

Target: PRSS3 (Protease, serine, 3 (PRSS3))

Alternative Name: PRSS3

Background:

Protein Function: Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5. .

Background: Trypsin is a serine protease from the PA clan superfamily, found in the digestive system of many vertebrates, where it hydrolyses proteins. In the duodenum, trypsin catalyzes the hydrolysis of peptide bonds, breaking down proteins into smaller peptides. The peptide products are then further hydrolyzed into amino acids via other proteases, rendering them available for absorption into the blood stream. Tryptic digestion is a necessary step in protein absorption as proteins are generally too large to be absorbed through the lining of the small intestine. Additionally, Trypsin is produced as the inactive zymogen trypsinogen in the pancreas. When the pancreas is stimulated by cholecystokinin, it is then secreted into the first part of the small intestine (the duodenum) via the pancreatic duct. Once in the small intestine, the enzyme enteropeptidase activates trypsinogen into trypsin by proteolytic cleavage. Auto catalysis can happen with trypsin using trypsinogen as the substrate. This activation mechanism is common for most serine proteases, and serves to prevent autodegradation of the pancreas.

Synonyms: Trypsin-3,3.4.21.4,Brain trypsinogen,Mesotrypsinogen,Serine protease 3,Serine protease 4,Trypsin III,Trypsin IV,PRSS3,PRSS4, TRY3, TRY4,

Full Gene Name: Trypsin-3

Cellular Localisation: Secreted.

UniProt: P35030