KREMEN1 ELISA Kit

Catalog No. ABIN5510702

This Mouse KREMEN1 ELISA Kit is a Colorimetric ELISA Kit designed to quantify Mouse KREMEN1.

Quick Overview for KREMEN1 ELISA Kit (ABIN5510702)

Target: KREMEN1 (Kringle Containing Transmembrane Protein 1 (KREMEN1))

Binding Specificity: AA 20-395

Reactivity: Mouse

Detection Method: Colorimetric

Method Type: Sandwich ELISA

Application: ELISA

Product Details KREMEN1 ELISA Kit

Purpose: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse Kremen-1

Brand: PicoKine™

Analytical Method: Quantitative

Specificity: Expression system for standard: NSO
Immunogen sequence: A20-G395

Cross-Reactivity (Details): There is no detectable cross-reactivity with other relevant proteins.

Characteristics:

Tissue Specificity: In the adult, widely expressed with high levels in heart, lung, kidney, skeletal muscle and testis. .

Application Details

Plate: Pre-coated

Restrictions: For Research Use only

Handling

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Expiry Date: 12 months

Target Details for KREMEN1

Target: KREMEN1 (Kringle Containing Transmembrane Protein 1 (KREMEN1))

Alternative Name: Kremen1

Background:

Protein Function: Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling (By similarity). .

Background: Kremen protein 1 is a protein that in humans is encoded by the KREMEN1 gene. This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.

Synonyms: Kremen protein 1,Dickkopf receptor,Kringle domain-containing transmembrane protein 1,Kringle-containing protein marking the eye and the nose,Kremen1,Kremen,

Full Gene Name: Kremen protein 1

Cellular Localisation: Membrane, Single-pass type I membrane protein.

UniProt: Q99N43

Pathways: WNT Signaling