TNFRSF19 ELISA Kit

Catalog No. ABIN5510740

This Colorimetric ELISA kit is designed for the quantitative measurement of Mouse TNFRSF19.

Quick Overview for TNFRSF19 ELISA Kit (ABIN5510740)

Target: TNFRSF19 (Tumor Necrosis Factor Receptor Superfamily, Member 19 (TNFRSF19))

Binding Specificity: AA 30-170

Reactivity: Mouse

Detection Method: Colorimetric

Method Type: Sandwich ELISA

Application: ELISA

Product Details TNFRSF19 ELISA Kit

Purpose: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse TNFRSF19/TROY

Analytical Method: Quantitative

Specificity: Expression system for standard: NSO, Immunogen sequence: E30-L170

Cross-Reactivity (Details): There is no detectable cross-reactivity with other relevant proteins.

Characteristics:

Tissue Specificity: Highly expressed in adult brain, and in embryos from day 11-17, but not earlier. Detected in embryonic brain and epithelium, and at lower levels in adult heart, lung and liver. In neonatal mice, mainly in hair follicles and neuron-like cells in the cerebellum, but not in the skin epidermis. Isoform 3 was found in embryonic day 17.5 skin but not in brain and liver.

Application Details

Plate: Pre-coated

Restrictions: For Research Use only

Handling

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Expiry Date: 12 months

Target Details for TNFRSF19

Target: TNFRSF19 (Tumor Necrosis Factor Receptor Superfamily, Member 19 (TNFRSF19))

Alternative Name: Tnfrsf19

Background:

Protein Function: Can mediate activation of c-Jun and NF-kappa-B. May promote caspase-independent cell death (By similarity). Isoform 2 and isoform 3 may act as decoy receptors. .

Background: Tumor necrosis factor receptor superfamily, member 19, also known as TNFRSF19 and TROY, is a human gene. It is mapped to 13q12.11-q12.3. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Synonyms: Tumor necrosis factor receptor superfamily member 19,TRADE,Toxicity and JNK inducer,Tnfrsf19,Taj, Troy,

Full Gene Name: Tumor necrosis factor receptor superfamily member 19

Cellular Localisation: Isoform 1: Cell membrane, Single-pass type I membrane protein.

UniProt: Q9JLL3