ModDetect® 2'-O-Methoxyethyl (2'MOE) Panel

Catalog No. ABIN7675639

Supplier Product No.: kna-200

Quick Overview for ModDetect® 2'-O-Methoxyethyl (2'MOE) Panel (ABIN7675639)

Target: DNA (Deoxyribonucleic Acid (DNA))

Product Details

Binding Specificity: 2'-O-Methoxyethyl

Clonality: Monoclonal

Supplier Product No.: kna-200

Supplier: Rockland

Purpose: ModDetect® 2'-O-Methoxyethyl (2'MOE) Panel

Brand: ModDetect®

Components: The set includes five unlabeled ModDetect® 2'-O-Methoxyethyl (2'MOE) detection reagents [clone MOE1 (200-301-NF0S), clone MOE3 (200-301-NF1S), clone MOE4 (200-301-NF2S), clone MOE9 (200-301-NF3S), and clone MOEC (200-301-NF4S)], curated by binding characteristics, and three rabbit Anti-Mouse IgG reporter molecules labeled with peroxidase (ABIN5608149), 488 λ fluorophore (ABIN6698973), and 649 λ fluorophore (ABIN6698977). The different binding characteristics create opportunities to generate highly optimized immunoassays independent of oligonucleotide sequence, as opposed to spending significant efforts to optimize assays to underperforming reagents. Designed for use in various immunoassays, such as ELISA, IF, and IHC.
NOTE: Panel detection reagents components are provided in a 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride buffer, pH 7.2. This buffer contains 0.01 % Sodium Azide as a preservative and 10 mg/mL carrier protein as a stabilizing reagent.

Product Specific Information:

The ModDetect™ 2′-O-Methoxyethyl (MOE) Panel enables antibody-based detection of MOE-modified oligonucleotides used to enhance stability and tolerability. MOE modifications are frequently incorporated into antisense and RNA-based therapeutics but are challenging to evaluate with conventional assays. This panel targets the MOE chemical feature directly, allowing sequence-independent analysis across oligonucleotide designs. The antibodies are compatible with ELISA, immunofluorescence, and tissue-based assays. These reagents support biodistribution, localization, and quantitative assessment in research and preclinical workflows.

Application Details

Application Notes: Designed for use in various immunoassays, such as ELISA, IF, and IHC and establishment of said assays

Restrictions: For Research Use only

Handling

Format: Lyophilized or Liquid

Buffer: Panel detection reagents components are provided in a 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride buffer, pH 7.2. This buffer contains 0.01 % Sodium Azide as a preservative and 10 mg/mL carrier protein as a stabilizing reagent.

Handling Advice: Avoid cycles of freezing and thawing. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. Dilute only prior to immediate use.

Storage: 4 °C,-20 °C

Storage Comment: Store five 2'-O-Methoxyethyl vials at -20°C or below prior to opening. Store the vial at -20°C or below after dilution. Avoid cycles of freezing and thawing. Store three reporter molecule vials at 4°C or -20°C prior to restoration. For extended storage aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details

Target: DNA (Deoxyribonucleic Acid (DNA))

Alternative Name: DNA

Target Type: Chemical

Background: 2'-O-Methoxyethyl, 2'MOE, ASO, anti-sense oligonucleotide