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Full name:: SAR1 Homolog B (S. Cerevisiae) Proteins (SAR1B)

On www.antibodies-online.com are 10 SAR1 Homolog B (S. Cerevisiae) (SAR1B) Proteins from 5 different suppliers available. Additionally we are shipping SAR1B Antibodies (95) and and many more products for this protein. A total of 115 SAR1B products are currently listed.

Synonyms:: 2310075M17Rik, 2900019I22Rik, ANDD, cmrd, GTBPB, SAR1, sar1a, SAR1B, SARA1B, sara2, Sarb, zgc:73204

list all proteins	Gene Name	GeneID	UniProt
	SAR1B	66397	Q9CQC9
	SAR1B	287276	Q5HZY2
	SAR1B	51128	Q9Y6B6
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SAR1B Proteins (SAR1B) by Origin

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Relevant Pathways for SAR1B Proteins

Lipid Metabolism

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Mouse (Murine) SAR1 Homolog B (S. Cerevisiae) (SAR1B) interaction partners

Data suggest the importance of small Sar1b GTPase (Sar1b) in organs involved in lipid transport and/or calcium trafficking such as the liver, intestine, skeletal muscle and heart.

Human SAR1 Homolog B (S. Cerevisiae) (SAR1B) interaction partners

Study data suggest that SAR1A and SAR1B are the critical regulators of trafficking of Nav1.5. Moreover, SAR1A and SAR1B interact with MOG1, and are required for MOG1-mediated cell surface expression and function of Nav1.5.
Targeted next generation DNA sequencing revealed several rare heterozygous missense variants in both MTTP and APOB genes known or predicted to be deleterious, in addition to a novel heterozygous missense variant in SAR1B, which encodes the gene causing chylomicron retention disease
Report compensatory Sar1a elevation after Sar1b gene deletion in Caco-2/15 cells prevents chylomicron collapse.
SAR1B polymorphisms were associated with Alzheimer's disease (AD) risk; results were not significant after correction for multiple tests. Simultaneous screening using SAR1B rs11948613 and ApoE epsilon4 status offered a better sensitivity for AD screening.
Our data also suggest that Sar1B overexpression contributes to regulation of CHOL transport and metabolism by facilitating rapid uptake and transport of CHOL.
although Sar1A antagonizes the lipoprotein secretion-promoting activity of Sar1B, both isoforms modulate the expression of genes encoding cholesterol biosynthetic enzymes and the synthesis of cholesterol de novo.
the behavior of the human of Sar1A and Sar1B, a key component of the COPII family of vesicle coat proteins, was examined.
Sar1b expression may promote intestinal lipid transport with the involvement of the coat protein complex II network and the processing of SREBP-1c.
Variable phenotypic expression of chylomicron retention disease in a kindred carrying a mutation of the Sara2 gene.
identify eight mutations in SARA2 that are associated with three severe disorders of fat malabsorption
Sara2 is an important gene in processes involving erythroid cell proliferation and differentiation.
Five mutations in the SAR1B gene causing Anderson disease.
muscular as well as cardiac abnormalities that could be related to the reported expression of SARA2 in these tissues

SAR1B Protein Profile

Protein Summary

The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD). Two transcript variants encoding the same protein have been found for this gene.

Alternative names and synonyms associated with SAR1B

secretion associated Ras related GTPase 1B (SAR1B)
hypothetical protein (Sar1B)
SAR1 homolog B (S. cerevisiae) (sar1b)
secretion associated Ras related GTPase 1B (Sar1b)
secretion associated, Ras related GTPase 1B L homeolog (sar1b.L)
secretion associated, Ras related GTPase 1B (Sar1b)
secretion associated, Ras related GTPase 1B (sar1b)

2310075M17Rik protein
2900019I22Rik protein
ANDD protein
cmrd protein
GTBPB protein
SAR1 protein
sar1a protein
SAR1B protein
SARA1B protein
sara2 protein
Sarb protein
zgc:73204 protein

Protein level used designations for SAR1B

SAR1 gene homolog B , GTP-binding protein SAR1b , SAR1 homolog B , hypothetical protein , GTP-binding protein sar1b , SAR1a gene homolog 2 , SAR1b gene homolog , 2310075M17Rik , GTP-binding protein B , GTP-binding protein Sara

GENE ID	SPECIES
462069	Pan troglodytes
711269	Macaca mulatta
7194978	Phaeodactylum tricornutum CCAP 1055/1
100528293	Ictalurus punctatus
100758826	Cricetulus griseus
66397	Mus musculus
387598	Xenopus laevis
287276	Rattus norvegicus
51128	Homo sapiens
554177	Danio rerio
416314	Gallus gallus
481509	Canis lupus familiaris
494017	Sus scrofa
515999	Bos taurus

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