EDG-2
BUD31
PC, WB
Whole Cell Lysate
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- Target See all BUD31 products
- BUD31 (BUD31 Homolog (BUD31))
- Application
- Positive Control (PC), Western Blotting (WB)
- Lysate Fraction
- Whole Cell Lysate
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- Application Notes
- For use as a positive control with EDG-2 polyclonal antibody ABIN187787 for Western blot analysis. Use 10 µl of EDG-2 cell lysate per lane as a control for using EDG-2 antibody.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Cell lysate provided in 10% glycerol, 0.063 M Tris-HCl (pH 6.8), 2% SDS and 0.002% bromophenol blue, 5% 2-mercaptoethanol.
- Storage
- -20 °C
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- Target
- BUD31 (BUD31 Homolog (BUD31))
- Alternative Name
- EDG-2 (BUD31 Products)
- Background
- EDG-2 Transfected Cell Positive Control Lysate. Provided in 10% glycerol, 0.063 M Tris-HCl (pH 6.8), 2% SDS and 0.002% bromophenol blue, 5% 2-Mercaptoethanol. Endothelial cell differentiation gene-2 (EDG-2) receptor is a high affinity receptor for lysophosphatidic acid (LPA). EDG-2, also known as lysopholipid receptor A1, Vzg-1, mrec1.3 or GPCR26, like all other EDG receptors, couple multiple (3 or more) types of G proteins and transduce decreases in c[AMP]i through Gi and increases in [Ca 2+ ]i by augmenting phos- pholipase C through Gq/11 and beta/gamma dimmers and by induction of PI3 kinase, p125 FAK, phospholipase D by activating rho through G12/13. Human EDG-2 is present in high levels on oligodendrocytes and certain human malignant T cell lines. EDG-2 receptors (with EDG-4) may play a role in protecting cardiomyocytes from apoptosis induced by hypoxia and andrenergic stimulation.
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