This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008].
Flach, Leu, Martinisi, Skachokova, Frank, Tolnay, Stahlberg, Winkler: "Trans-seeding of Alzheimer-related tau protein by a yeast prion." in: Alzheimer's & dementia : the journal of the Alzheimer's Association, Vol. 18, Issue 12, pp. 2481-2492, (2023) (PubMed).
Aliases for MAPT Proteins
microtubule associated protein tau (MAPT) Proteins microtubule-associated protein tau (Mapt) Proteins microtubule associated protein tau S homeolog (mapt.S) Proteins microtubule-associated protein tau (LOC5580230) Proteins microtubule-associated protein tau (CpipJ_CPIJ013260) Proteins Microtubule-associated protein tau (tau) Proteins microtubule associated protein tau (Mapt) Proteins solute carrier family 6 (neurotransmitter transporter), member 6b (slc6a6b) Proteins AI413597 Proteins AW045860 Proteins DDPAC Proteins FTDP-17 Proteins MAPT Proteins MAPTL Proteins MSTD Proteins Mtapt Proteins MTBT1 Proteins MTBT2 Proteins PHF-tau Proteins PPND Proteins pTau Proteins RNPTAU Proteins slc6a6 Proteins TAU Proteins Tau Proteins tau Proteins taut Proteins wu:fc26e12 Proteins xtp Proteins