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Human Polyclonal GCC2 Primary Antibody for IHC (p), IHC - ABIN451681
Efimov, Kharitonov, Efimova, Loncarek, Miller, Andreyeva, Gleeson, Galjart, Maia, McLeod, Yates, Maiato, Khodjakov, Akhmanova, Kaverina: Asymmetric CLASP-dependent nucleation of noncentrosomal microtubules at the trans-Golgi network. in Developmental cell 2007
Human Polyclonal GCC2 Primary Antibody for ICC, IF - ABIN4313718
Wong, Munro: Membrane trafficking. The specificity of vesicle traffic to the Golgi is encoded in the golgin coiled-coil proteins. in Science (New York, N.Y.) 2014
In light of existing report suggesting critical role of Nef-GCC185 interaction reveals valuable mechanistic insights affecting specific protein transport pathway in docking of late endosome derived Rab9 (show RAB9A Antibodies) bearing transport vesicle at TGN (show TG Antibodies) elucidating role of Nef during viral pathogenesis.
These unexpected features support a model in which GCC185 collapses onto the Golgi surface, perhaps by binding to Rab (show HRB Antibodies) GTPases, to mediate vesicle tethering.
Deletion of the ARL4A (show ARL4A Antibodies)-interacting region of GCC185 results in inability to maintain Golgi structure and modulate endosome-to-Golgi transport.
Two distinct domains of GCC185 are needed either for Golgi structure maintenance or transport vesicle tethering. The domain needed for vesicle tethering binds to the clathrin adaptor AP-1 (show FOSB Antibodies).
The ability of the four mammalian GRIP domain proteins, p230 (show GOLGA4 Antibodies), golgin-97 (show GOLGA1 Antibodies), GCC88 (show GCC1 Antibodies), and GCC185 to interact is reported.
These data assign a specific pathway to an interesting, TGN (show TG Antibodies)-localized protein and suggest that GCC185 may participate in the docking of late endosome-derived, Rab9 (show RAB9A Antibodies)-bearing transport vesicles at the TGN (show TG Antibodies).
GCC2 is required for endosome-to-Golgi transport and maintenance of Golgi structure.
Rab (show HRB Antibodies) and Arl GTPase (show RACGAP1 Antibodies) family members cooperate in the localization of GCC2.
Results show that GCC185 contains at least six binding sites for as many as 14 different Rab (show HRB Antibodies) GTPases across its entire length.
Study demonstrates that Golgi recruitment of endogenous GCC185 does not involve Rab6A (show RAB6A Antibodies)/A' and Arl1 (show ARL1 Antibodies).
The protein encoded by this gene is a peripheral membrane protein localized to the trans-Golgi network. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. Alternative splicing results in multiple transcript variants.
GRIP and coiled-coil domain containing 2
, GRIP and coiled-coil domain-containing 2
, GRIP and coiled-coil domain-containing protein 2
, GRIP and coiled-coil domain-containing protein 2-like
, 185 kDa Golgi coiled-coil protein
, CLL-associated antigen KW-11
, CTCL tumor antigen se1-1
, GCC protein, 185-kD
, Golgi coiled-coil protein GCC185
, Ran-binding protein 2-like 4
, renal carcinoma antigen NY-REN-53
, LIM and senescent cell antigen-like domains 1