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Data suggest that inability of lithium, an anti-manic agent, to regulate circadian rhythms in cells from patient with bipolar disorder reflects reduced ERK1/2 activity and MAP kinase (show MAPK1 Proteins) signaling through ELK1 (show ELK1 Proteins). (ERK (show EPHB2 Proteins) = extracellular signal-related kinase; ELK1 (show ELK1 Proteins) = ETS-domain protein (show ELK3 Proteins) ELK1 (show ELK1 Proteins))
Report differential expression of EZH2 (show EZH2 Proteins) protein in small cell and aggressive B-cell non-Hodgkin lymphomas and differential regulation of EZH2 (show EZH2 Proteins) expression by p-ERK1/2 and MYC (show MYC Proteins) in aggressive B-cell lymphomas.
Data indicate that PD0325901 inhibited extracellular signal-regulated kinases ERK1/2 phosphorylation.
Findings suggest that ERK1/2-mediated Cdk2 (show CDK2 Proteins)/cyclin A (show CCNA2 Proteins) signaling pathway is involved in 7-hydroxy-5,4'-dimethoxy-2-arylbenzofuran (Ary) - induced G1/S-phase arrest.
Endoplasmic reticulum stress contributes to nefazodone-induced toxicity in HepG2 cells and ERK1/2 signaling pathway plays an important role.
ERK1 Directly Interacts With JNK1 (show MAPK8 Proteins) Leading to Regulation of JNK1 (show MAPK8 Proteins)/c-Jun (show JUN Proteins) Activity and Cell Transformation.
egulation of apoptosis was far more sensitive than regulation of proliferation. IGF1 (show IGF1 Proteins) and insulin (show INS Proteins) activated PKB (Akt/PKB (show AKT1 Proteins)) rapidly and consistently maintained its phosphorylation. Activation of ERK1/2 was only observed in response to IGF1 (show IGF1 Proteins).
Data show that oxidative stress and MAP kinase phosphatase 3 (MKP3 (show DUSP6 Proteins)) inhibition play a critical role in procyanidin B2 3,3''-di-O-gallate (B2G2)-induced cell death in prostate cancer (PCa (show FLVCR1 Proteins)) cells through sustained activation of both ERK1/2 and AMPKalpha (show GRK4 Proteins).
these findings propose that A3AR (show ADORA3 Proteins) agonist induces cell cycle arrest and apoptosis in breast cancer stem cells by inhibition of ERK1/2 and GLI-1 (show GLI1 Proteins) cascade.
Data show that Cx43 (show GJA1 Proteins) was inhibited predominantly via IL-1beta (show IL1B Proteins)-activated ERK1/2 and p38 MAP kinase (show MAPK14 Proteins) cascades.
North American ginseng inhibits myocardial NOX2 (show CYBB Proteins)-ERK1/2-TNF-alpha (show TNF Proteins) signaling pathway and improves cardiac function in endotoxemia, suggesting that NA ginseng may have the potential in the prevention of clinical sepsis.
NF-alpha1 is critical for regulating antiproliferation and cell fate determination, through differentiating embryonic stem cells to GFAP (show GFAP Proteins)-positive astrocytes for normal neurodevelopment.
These findings suggested that USP14 induces NF-kappaB activity and ERK1/2 phosphorylation triggered by microbial infection.
Cortical neuron-specific deletion of extracellular signal-regulated kinases Erk1 or Erk2 (show MAPK1 Proteins) significantly increased the duration of wakefulness.
pERK1/2 is a regulator of CD44 (show CD44 Proteins) expression, and increased CD44 (show CD44 Proteins) expression leads to a pro-sclerotic and migratory parietal epithelial cell phenotype in focal segmental glomerulosclerosis.
mmLDL increased the serum concentrations and expression of ICAM-1 (show ICAM1 Proteins) and VCAM-1 (show VCAM1 Proteins) by activating the ERK1/2 pathway, resulting in the expression of ETB (show EDNRB Proteins) receptors and the enhancement of contractile function in vascular smooth muscle.
Angiotensin II regulates dendritic cells through activation of p65 NF-kappaB (show NFkBP65 Proteins), ERK1, ERK2 (show MAPK1 Proteins) and STAT1 (show STAT1 Proteins) pathways.
MAPK3/1 participates in primordial follicle activation through mTORC1-KITL (show KITLG Proteins) signaling.
At low oxLDL levels LOX-1 activates the protective Oct-1/SIRT1 pathway, while at higher levels of the lipoprotein switches to the thrombogenic ERK1/2 pathway.
Studies indicate that progesterone receptor transgenic (Pgrcre/+) mitogen inducible gene 6 (Mig-6over) phosphatase and tensin homolog protein (Ptenf/f) knockout mice exhibited an increase of phospho-ERK1/2 and its target genes.
ERK1/2-Akt1 (show AKT1 Proteins) crosstalk regulates arteriogenesis in mice and zebrafish.
eena (show SH3GL1 Proteins) plays an important role in the development of the myeloid cell through activation of the ERK1/ERK2 (show MAPK1 Proteins) pathway
ERK1 and ERK2 (show MAPK1 Proteins) target common and distinct gene sets, confirming diverse roles for these kinases during embryogenesis; for ERK1 different specific genes involved in dorsal-ventral patterning and subsequent embryonic cell migration were identified.
These results demonstrate that induction of Hsp70 (show HSPA1A Proteins) in response to heat stress is dependent on ERK (show MAPK1 Proteins) activation in Pac2 (show PSMG2 Proteins) cells.
Data define distinct roles for ERK1 and ERK2 (show MAPK1 Proteins) in developmental cell migration processes during zebrafish embryogenesis.
MAPK3/1 is involved in luteinizing hormone-mediated decrease of C-type natriuretic peptide (show NPPC Proteins) and this process is related to the EGFR (show EGFR Proteins) and MAPK3/1 signal pathways
Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling.
ER Ca(2+) release enhances eNOS Ser-635 phosphorylation and function via ERK1/2 activation.
Thrombospondin 1 (show THBS1 Proteins), fibronectin (show FN1 Proteins), and vitronectin (show VTN Proteins) are differentially dependent upon RAS, ERK1/2, and p38 (show MAPK14 Proteins) for induction of vascular smooth muscle cell chemotaxis.
results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
These data suggest that Gab1-ERK1/2 binding and their nuclear translocation play a crucial role in Egr-1 (show EGR1 Proteins) nuclear accumulation.
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.
This study demonstrates for the first time that cyclic mechanical stretch induces the proliferation of bovine satellite cells and suppresses their myogenic differentiation through the activation of ERK (show MAPK1 Proteins).
findings indicate that exposure to DHEA, at concentrations found in human blood, causes vascular endothelial proliferation by a plasma membrane-initiated activity that is Gi/o and ERK1/2 dependent.
Results suggest that estrogen receptors and the ERK1/2 signaling pathway are involved in the anti-apoptotic action of LY117018 in vascular endothelial cells.
Early activation of MAPK p44/42 is involved in deoxynivalenol -induced disruption of intestinal barrier function and tight junction network signaling.
Pseudorabies virus glycoprotein gE-mediated ERK 1/2 phosphorylation also occurs in epithelial cells and in these cells, gE-mediated ERK 1/2 signaling is associated with degradation of the pro-apoptotic protein Bim (show BCL2L11 Proteins).
Treatment with ERK inhibitors or ERK1/2 knockdown significantly suppressed porcine epidemic diarrhea virus progeny production.
This study reveals a new function of the gE glycoprotein of pseudorabies virus and suggests that pseudorabies virus, through activation of ERK1/2 signaling, has a substantial impact on T cell behavior.
CSF2 (show CSF2 Proteins) stimulates proliferation of trophectoderm cells by activation of the PI3K-and ERK1/2 MAPK (show MAPK1 Proteins)-dependent MTOR (show FRAP1 Proteins) signal transduction cascades.
PGRN (show GRN Proteins) inhibits adipogenesis in porcine preadipocytes partially through ERK (show MAPK1 Proteins) activation mediated PPARgamma (show PPARG Proteins) phosphorylation.
Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK (show PRKAA1 Proteins)/ERK (show MAPK1 Proteins)/TSC2/mTOR (show FRAP1 Proteins) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis
Data show that proinflammatory cytokines induction was ERK1/2 and JNK1 (show MAPK8 Proteins)/2 dependent.
Saccharomyces cerevisiae inhibits the Enterotoxigenic Escherichia coli-induced expression of pro-inflammatory transcripts and this inhibition was associated to a decrease of ERK1/2 and p38 MAPK (show MAPK14 Proteins) phosphorylation
ERK1 phosphorylation in response to Insulin-like Growth Factor-1 (show IGF1 Proteins) does not require activation of the Insulin-like Growth Factor-1 receptor tyrosine kinase (show IGF1R Proteins)
The results suggest that the MPK-1 (show MAPK1 Proteins)/ERK (show MAPK1 Proteins) regulatory network, including FBF-1, FBF-2, and LIP-1 (show CENPJ Proteins), controls the number of sperm by regulating the timing of the sperm-oocyte switch in C. elegans.
Cek2 (show FGFR3 Proteins) has a cryptic role in cell-wall biogenesis and its role is not entirely redundant to Cek1.
knockdown of SUV420H1 (show SUV420H1 Proteins) reduced phosphorylated ERK1 and total ERK1 proteins, and interestingly suppressed ERK1 at the transcriptional level
Secreted aspartic protease-mediated proteolytic cleavage of Msb2 is required for activation of the Cek1 mitogen activated protein kinase (show MAPK1 Proteins) pathway in response to environmental cues.
The authors propose that a Msb2, Cek1 and Ace2 signalling pathway addresses PMT genes as downstream targets and that different modes of regulation have evolved for PMT1 and PMT2/PMT4 genes.
Msb2 is involved in the transmission of the signal toward Cek1 mediated by the Cdc42 (show CDC42 Proteins) GTPase (show RACGAP1 Proteins).
constitutively active (CA)-MPK3 crosses with summ1 and summ2, two known suppressors of mpk4 (show MAPK4 Proteins), resulted in a partial reversion of the CA-MPK3 phenotypes.
that MPK3/MPK6 phosphorylate and destabilize ICE1, which negatively regulates CBF expression and freezing tolerance in plants
Changes in PUB22 Ubiquitination Modes Triggered by MITOGEN-ACTIVATED PROTEIN KINASE3 Dampen the Immune Response
MPK3 role in ultraviolet induced stomatal closure
Study propose that the pathogen-responsive MPK3/MPK6 (show MAPK6 Proteins) cascade and ABA are two essential signaling pathways that control, respectively, the organic acid metabolism and ion channels, two main branches of osmotic regulation in guard cells that function interdependently to control stomatal opening/closure.
Data report that MPK3/MPK6 and their substrate ERF6 promote the biosynthesis of IGSs and the conversion of I3G to 4MI3G, a target of PEN2/PEN3-dependent chemical defenses in plant immunity.
Data show that the protein kinases MPK3 and MPK6 (show MAPK6 Proteins) can both interact with SPOROCYTELESS/NOZZLE (SPL (show SGPL1 Proteins)) in vitro and in vivo and can phosphorylate the SPL (show SGPL1 Proteins) protein in vitro.
MKK4 (show MAP2K4 Proteins), MKK5 (show MAP2K5 Proteins), MKK7 (show MAP2K7 Proteins), and MKK9, are responsible for the activation of MPK3 and MPK6 (show MAPK6 Proteins) by melatonin, indicating that melatonin-mediated innate immunity is triggered by MAPK (show MAPK1 Proteins) signaling through MKK4 (show MAP2K4 Proteins)/5/7/9-MPK3/6 cascades.
Phosphatase AP2C1, as well as AP2C1-targeted MPK3 and MPK6 (show MAPK6 Proteins), are important regulators of plant-nematode interaction, where the co-ordinated action of these signalling components ensures the timely activation of plant defence.
Results demonstrated the contribution of MPK3 and MPK6 (show MAPK6 Proteins) to riboflavin-induced resistance.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.
MAP kinase isoform p44
, MAPK 1
, extracellular signal-regulated kinase 1
, extracellular signal-related kinase 1
, insulin-stimulated MAP2 kinase
, microtubule-associated protein 2 kinase
, MAP kinase 3
, p44 MAP kinase
, pp42/MAP kinase
, mitogen-activated protein kinase 3
, MAP kinase 12
, MAPK 12
, extracellular signal-regulated kinase 6
, mitogen-activated protein kinase 12
, stress-activated protein kinase 3
, MAP kinase 1
, MAPK 3
, mitogen-activated 3
, mitogen-activated protein kinase 1
, extracellular signal-regulated kinase-1
, likely protein kinase