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Mouse (Murine) Peroxisome Proliferator-Activated Receptor gamma (PPARG) interaction partners

1. The transcription factor PPAR-gamma is a key regulator of lung immunity exhibiting multiple cell type specific roles in controlling development and function of the lung immune system. Review.

2. These findings provide a novel mechanism by which XBP1s stimulate insulin sensitivity in adipocytes through fibroblast growth factor 21 induction and PPARgamma activation.

3. These results suggest that the ketogenic diet regulates catalase expression through PPARgamma2 activation, and that catalase may contribute to the ketogenic diet antiseizure efficacy.

4. these findings highlight crucial roles for Sema6D reverse signaling in macrophage polarization, coupling immunity, and metabolism via PPARgamma.

5. Alkyl-glycerophosphate plays a significant role in the initiation/progression of diabetes-related atherosclerosis through PPARgamma activation.

6. These results demonstrated that chlorogenic acid (CGA) might function as a potential PPARgamma agonist similar to Rosiglitazone (RG); however, the impact of CGA on lipolysis in 3T3-L1 preadipocytes differed from that of RG.

7. Diet-induced obesity PPARgamma-K107R-mutant mice have enhanced insulin sensitivity without the corresponding increase in adiposity.

8. adipose tissue-derived miR-27a may play a key role in the development of obesity-triggered insulin resistance in skeletal muscle.

9. Peroxisome proliferator activated receptor gamma (PPARgamma) is recruited to the genome in a ligand-independent manner upon macrophage polarization.

10. These findings delineate instrumental mechanisms underlying the active lipid metabolism and suppressed glycolysis in PT and active glycolysis in DT and reveal critical roles for PPARs and c-Myc in maintaining renal metabolic homeostasis.

11. PPARgamma activation, which down-regulates macrophage pro-inflammatory responses, impacts the lung's response to M. tb infection, thereby supporting PPARgamma's role in tuberculosis pathogenesis.

12. These results suggested that PPARgamma regulates the S1P levels by modulating apoM in a bell-shaped manner, with the greatest levels of apoM/S1P observed when PPARgamma was mildly expressed and that hepatic apoM/PPARgamma axis might maintain the homeostasis of S1P metabolism.

13. This study emphasizes the importance of PPARgamma phosphorylation in controlling bone mass and marrow adiposity and demonstrates how a regulatory mutation in PPARgamma previously associated with peripheral fat metabolism can have broader effects on bone homeostasis that may in turn affect whole body energy metabolism.

14. Concurrent exercise improves insulin resistance and nonalcoholic fatty liver disease by upregulating PPAR-gamma, CPT-1A and Mcad activities.

15. These results reveal novel genes and networks modulated by PPARgamma.

16. the zinc-finger transcription factor Kruppel-like factor 10 (KLF10) is induced after adipogenic induction and that its expression positively correlates with that of C/EBPbeta but inversely correlates with expression of C/EBPalpha and PPARgamma.

17. crosstalk between GCR and PPARgamma is largely synergistic but counter-regulatory in lipogenic genes, of which enhancement prevents excessive glycerol and possibly FFA release by glucocorticoids into the circulation.

18. Taken together, PPARalpha-mediated metabolic induction and proliferation of peroxisomes via a PPRE-dependent mechanism could compensate PPARgamma-deficiency in club cells.

19. PPARgamma is essential for the skin infection transition to the post-inflammatory resolution phase and methicillin-resistant Staphylococcus aureus clearance.

20. P465L mutation confers partial resistance to the hypolipidemic action of fibrates. The fatty liver phenotype observed in P465L mutant mice is not only the consequence of dysfunctional adipose tissue, but also involves defective liver metabolism. All in all, the deleterious effects of P465L-PPARgamma mutation may be magnified by their collateral negative effect on PPARalpha function.

Human Peroxisome Proliferator-Activated Receptor gamma (PPARG) interaction partners

1. among the 10 SNPs negatively associated with Nonalcoholic Fatty Liver Disease, the four-locus model (rs13431696 and rs3856806 in PPARgamma, and rs5182, rs1492100 in ATGR1) and the five-locus model (rs9817428, rs1175543, rs13433696, and rs2920502 in PPARgamma, and rs1492100 in ATGR1) were closely related with Nonalcoholic Fatty Liver Disease susceptibility (p = 0.019 and p = 0.048, respectively).

2. These results conclude linc01230 as a novel modifier in PPARgamma-mediated activation of Akt in endothelial function.

3. The transcription factor PPAR-gamma is a key regulator of lung immunity exhibiting multiple cell type specific roles in controlling development and function of the lung immune system. Review.

4. Pro12Ala polymorphism of the PPAR-gamma2 gene cannot be considered as a risk factor for non alcoholic fatty liver disease in the Iranian population.

5. upregulation of microRNAs 27b, 130b and 138 is associated with susceptibility to CRC in obese subjects through PPARgamma downregulation. Hypermethylation of PPARgamma gene promoter is associated with CRC through suppression of PPARgamma regardless of BMI.

6. The modified transcriptional activity of PPAR-gamma gene, associated with lipid and carbohydrate metabolism, has a direct effect on the weight gain during pregnancy.

7. The expansion of CB HSPCs by PPAR-gamma antagonism was completely suppressed by removal of glucose or inhibition of glycolysis. Moreover, knockdown of FBP1 expression promoted glycolysis and ex vivo expansion of long-term repopulating CB HSPCs, whereas overexpression of FBP1 suppressed the expansion of CB HSPCs that was induced by PPARG antagonism

8. Data indicate that synthetic ligand and fatty acid cobinding can form a 'ligand link' to the Omega-loop and synergistically affect the structure and function of peroxisome proliferator-activated receptor gamma (PPARgamma).

9. Alkyl-glycerophosphate plays a significant role in the initiation/progression of diabetes-related atherosclerosis through PPARgamma activation.

10. The DHEA metabolite 7beta-hydroxy-epiandrosterone exerts anti-estrogenic effects on breast cancer cell lines.

11. this study shows that impaired anti-inflammatory activity of PPARgamma in the salivary epithelia of Sjogren's syndrome patients is imposed by intrinsic NF-kappaB activation

12. adipose tissue-derived miR-27a may play a key role in the development of obesity-triggered insulin resistance in skeletal muscle.

13. The presence of FTO and/or PPARgamma SNPs might be related to a genetic predisposition to metabolic syndrome.

14. These results suggested that PPARgamma regulates the S1P levels by modulating apoM in a bell-shaped manner, with the greatest levels of apoM/S1P observed when PPARgamma was mildly expressed and that hepatic apoM/PPARgamma axis might maintain the homeostasis of S1P metabolism.

15. beta-Conglycinin and fish oil are effective at preventing alcoholic fatty liver because beta-conglycinin decreases the function of SREBP-1c and PPARgamma2, and fish oil decreases the function of SREBP-1c and increases that of PPARalpha

16. Neither the PPARgamma nor the IRS-1 polymorphism was associated with mortality outcome in breast-cancer patients. The TNF-alfa -308 G > A polymorphism was associated with reduced breast-cancer-specific and all-cause mortality.

17. Soft substrate attenuates M1-like macrophage polarization and predominantly induced the M2-like macrophage polarization through induction of PPARgamma expression.

18. Our data suggest that activation of the PPARgamma pathway differentiates Ductal carcinoma in situ (DCIS) and may be a useful approach to delay DCIS progression.

19. Study reveals genomic alterations of PPARG that lead to pro-tumorigenic PPARgamma/RXRalpha pathway activation in luminal bladder tumors and may open the way towards alternative options for treatment.

20. In a Chinese population, the AA genotype indivduals with rs13433696 in PPARG exhibited a decreased hypertriglyceridemia risk.

Pig (Porcine) Peroxisome Proliferator-Activated Receptor gamma (PPARG) interaction partners

1. Study demonstrated that overexpression of DNMT3A promoted the expression of cell proliferation markers but significantly decreased the expression of p21 to repress cell proliferation by the methylation of p21 promoter. Moreover, overexpression of DNMT3A decreased lipid accumulation and significantly down-regulated the levels of adipogenic marker genes through the methylation of PPARg promoter.

2. Our results provide novel insights into regulation of PPAR expression in ovarian follicles. We observed that FSH increased mRNA and protein expression of all PPARs isoforms, while LH only increased PPAR alpha and gamma. Steroids like progesterone and estradiol increased expression of PPAR alpha and gamma without affecting the beta isoform, while testosterone had no effect on all PPARs expression.

3. The results of the present study suggested that PPARG may mediate porcine placental angiogenesis, by interfering with hypoxia inducible factor, vascular endothelial growth factor and angiopoietinmediated signaling.

4. The results suggest the higher expression of miR-130a, which targeting peroxisome proliferator-activated receptor gamma, may be the reason for less fat deposition in intramuscular adipose tissue than subcutaneous adipose tissue.

5. The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR and PPARg. In summary, PPARg plays an important role in the regulation of IGF-1 secretion and gene expression in response to dietary protein.

6. The regulatory role of microRNA miR-27b-3p on peroxisome proliferator-activated receptor-gamma (PPARgamma) was confirmed by their inversed expression patterns in oocytes: [miR-27b-3p]

7. an Enhancer box and a binding site for a cooperative co-activator of MyoD are present in the promoter region of porcine PPARgamma.

8. The data suggest that there is local cooperation between resistin and PPARgamma expression in the porcine ovary. Resistin significantly increased the expression of PPARgamma, whereas PPARgamma decreased resistin expression; thus, PPARgamma is a new key regulator of resistin expression and function.

9. Therefore, this study demonstrated that the different regulatory adipogenic roles of MSTN in ADSCs and MSCs act by differentially regulating PPARgamma and MyoD expression.

10. PGRN inhibits adipogenesis in porcine preadipocytes partially through ERK activation mediated PPARgamma phosphorylation.

11. Resveratrol activated sirtuin 1 (Sirt1) gene expression and increased adipose triglyceride lipase (ATGL) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 regulation pattern for PPARgamma to that of ATGL in adipocytes.

12. The results indicate that the endometrial expression of PPARgamma genes fluctuates during the estrous cycle and pregnancy.

13. Increasing dietary DE linearly enhanced the expression of PPARgamma in adipose tissues but not skeletal muscle of Rongchang piglets.

14. These results suggest that trans-10, cis-12-conjugated linoleic acid can modulate TNF-alpha production and NF-kappa B expression by a PPARgamma-dependent pathway in porcine peripheral blood mononuclear cells.

15. The results indicated that PPARgamma gene was significantly associated with litter size in pigs.

16. Results indicated that PPARgamma is an essential regulatory factor for the transcriptional activity of ERp44, which in turn controls the secretion of adiponectin.

17. Endothelium on the pathosusceptible side of the aortic valve leaflet is responds to hypercholesterolemia with activation of a PPAR-gamma pathway.

18. PPAR profiles in bladder smooth muscle (BSM) may contribute to the susceptibility of BSM to lipotoxicity in the metabolic syndrome.

19. Our results raise doubts about the prevalently accepted anti-inflammatory role for PPAR-g activation.

20. Upregulation of PPAR-gamma and NADPH oxidases are involved in restenosis.

Cow (Bovine) Peroxisome Proliferator-Activated Receptor gamma (PPARG) interaction partners

1. This study shows that bta-miR-130a and bta-miR-130b play similar roles in the regulation of adipocyte differentiation in beef muscles by targeting the 3'UTR of PPARG and CYP2U1.

2. Results found that PPAR-gamma expression is regulated by miR-454 in bovine mammary epithelial cells (BMECs). miR-454 directly targets the 3'UTR of PPAR-gamma to regulate triglyceride synthesis in BMECs.

3. Three novel SNPs of the bovine PPARgamma gene were identified in 514 individuals from six Chinese cattle breeds: SNP1 (AC_000179.1 g.57386668 C > G) in intron 2 and SNP2 (AC_000179.1 g.57431964 C > T) and SNP3 (AC_000179.1 g.57431994 T > C) in exon 7.

4. These results indicated that docosahexaenoic acid may attenuate lipopolysaccharide-stimulated inflammatory response in bovine mammary epithelial cells by suppressing NF-kappaB activation through a mechanism partly dependent on PPARgamma activation.

5. PPARgamma is a positive regulator of milk fat synthesis in dairy cow mammary epithelial cells.

6. An Asp7Gly substitution in PPARG is associated with adiposity.

7. upregulation of PPARgamma was observed in the backfat tissue of Lilu cattle with increasing age

8. Co-culture of adipocytes and myoblasts elicited an increase in C/EBPbeta and PPAR-gamma gene expression in differentiated myoblasts and an increase in GPR43 gene expression in adipocytes.

9. A potential association of an single nucleotide polymorphism (72472 GT in exon7) of the bovine PPAR-gamma gene with carcass and meat quality traits, was evaluated.

10. study demonstrates the co-expression of DLX3, PPARG and SP1 in trophoblast binucleated cell(BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation

11. Single nucleotide polymorphisms in coding region of the PPARgamma gene, were examined.

12. oxidative stress attenuates PPAR gamma expression and activity in vascular endothelial cells

13. The effects of dietary fat components on the expression of PPAR-gamma AND PPAR-gamma coactivator 1 in cultured bovine preadipocytes are reported.

14. Intramammary infection elicited a strong transcriptomic response, leading to potent activation of pro-inflammatory pathways that were associated with a marked inhibition of lipid synthesis, stress-activated kinase signaling cascades, and PPAR signaling.

15. PPARgamma1 has bifunctional properties in the regulation of KDR gene expression mediated via interaction with both Sp1 and Sp3

16. There is evidence of cotranscription and intergenic splicing events between the PPARG gene and the neighboring gene TSEN2 in cattle. Two types of chimeric transcripts are observed.

Rhesus Monkey Peroxisome Proliferator-Activated Receptor gamma (PPARG) interaction partners

1. study found PPAR-gamma expression was prominent in the subthalamic nucleus, oculomotor nucleus, ventral tegmental nucleus, and to a lesser extent, in the putamen; 3 or 12 months after MPTP, only the lesioned putamen had increased PPAR-gamma

2. Aleglitazar, a dual PPARalpha/gamma agonist, has beneficial effects on both lipid and glucose parameters in a primate model of the metabolic syndrome.

Rabbit Peroxisome Proliferator-Activated Receptor gamma (PPARG) interaction partners

1. the present study demonstrated that RS protects primary myocardial cells against OGD/R injury by regulating PPARgamma and UCP2. RS may be a promising therapeutic agent for treatment of myocardial ischemia/reperfusion injury.

2. siRNA targeting PPARgamma gene can inhibit adipogenic differentiation of BMSCs and prevent steroid-induced osteonecrosis in rabbit.

3. vitamin E supplementation affords protection by decreasing MMP-1 and increasing PPARg, GSTa, and ABCA1 levels in aortae of rabbits fed a cholesterol-rich diet

4. Telmisartan improves microvascular dysfunction during myocardial ischemia/reperfusion injury via the PPARgamma pathway.

5. PPARgamma plays a luteotropic role in pseudopregnant rabbits, through PTGS2 down-regulation and 3beta-HSD up-regulation, with a consequent PGF2alpha decrease and progesterone increase.

6. In an animal model of atherosclerosis, the expression of PPAR-gamma is upregulated following atorvastatin administration.

7. Tongxinluo can inhibit the expression of MMP-3 and 9 and increase the expression of PPARgamma in atherosclerotic rabbits.

8. Niacin Reduces serum level and adipose mRNA expression of leptin and up-regulates PPARgamma and CD36 mRNA expression in hypercholesterolemic rabbits.

9. Antidiabetic drug pioglitazone protects the heart via activation of PPAR-gamma receptors, PI3-kinase, Akt, and eNOS pathway in a rabbit model of myocardial infarction.