Browse our anti-PPARG (PPARG) Antibodies

Mouse (Murine) Peroxisome Proliferator-Activated Receptor gamma (PPARG) interaction partners

1. HDAC3 (show HDAC3 Antibodies) inhibition in particular enhanced PPARgamma acetylation, prevented Klotho (show KL Antibodies) loss, and consequentially attenuated renal damage in mice model of chronic kidney disease.

2. additional transgenic mouse PPAR-gamma or pharmacological activation of PPAR-gamma effectively prevented transgenic mouse DNMT1 (show DNMT1 Antibodies)-induced proinflammatory cytokine production in macrophages and atherosclerosis development in the mouse model.

3. the suppression of Nrf2 (show NFE2L2 Antibodies) attenuates adipogenesis and decreases FGF21 (show FGF21 Antibodies) expression through PPARgamma in 3T3-L1 cells.

4. data demonstrated that reduction of Pparg expression in T-helper cells is critical for spontaneous SLE-like autoimmune disease development; we also revealed a novel function of PPARgamma in lymphocyte trafficking and cross talk between Th17 and B cells.

5. the extracts dramatically attenuated the levels of adipogenic transcriptional factors, including CCAAT enhancer-binding protein alpha (C/EBPa (show CEBPA Antibodies)), CCAAT enhancer-binding protein beta (C/EBPb (show CEBPB Antibodies)), and gamma receptors by peroxisome proliferators (PPARg), during adipogenesis

6. these findings identified an important role of renal tubular epithelium-targeted PPAR-gamma in maintaining the normal epithelial phenotype and opposing fibrogenesis, possibly via antagonizing oxidative stress

7. Activation of PPARgamma in hematopoietic stem cells impaired hematopoietic repopulation. PPARgamma inhibition by shRNA or chemical compounds significantly improves the repopulating ability of Fancd2 (show FANCD2 Antibodies)-/- HSCs.

8. Study found that the metabolic master regulator PGC-1alpha is differentially affected by ALS-associated mutations in brain vs. peripheral tissues. Increased PGC-1alpha activity in peripheral tissue contributes to the metabolic phenotype, while in the CNS blunting of the PGC-1alpha response renders motoneurons vulnerable.

9. DBZ is a putative PPARgamma agonist that prevents HFD-induced obesity-related metabolic syndrome and reverse gut (show GUSB Antibodies) dysbiosis. DBZ may be used as a beneficial probiotic agent to improve HFD-induced obesity-related metabolic syndrome in obese individuals

10. Altogether, the authors demonstrate that Dnmt3a (show DNMT3A Antibodies) and Dnmt3b (show DNMT3B Antibodies) protect the epidermis from tumorigenesis and that squamous carcinomas are sensitive to inhibition of PPAR-gamma.

Human Peroxisome Proliferator-Activated Receptor gamma (PPARG) interaction partners

1. Most of the tested flavonoids, but not the antioxidant vitamins, stimulated Nrf2 (show GABPA Antibodies)-, FoxO (show FOXO3 Antibodies)-, and PPARgamma-dependent promoter activities.

2. Findings suggest that despite their proposed involvement in the regulation of inflammatory processes in multiple sclerosis (MS), PPARalpha (show PPARA Antibodies), PPARbeta (show PPARD Antibodies)/delta, and PGC-1alpha proteins are not potential biomarkers of neuroinflammation in MS, and indicate a preferential role of PPARgamma in the endogenous regulation of autoimmune response in the human central nervous system within its receptor family.

3. combined administration of small-interfering RNA (siRNA) transfection with PPARgamma ligands induced downregulation of SOX2 (show SOX2 Antibodies) and MMP2 (show MMP2 Antibodies) activity together with inhibition of sphere-forming activity regardless of poly(ADP-ribose) polymerase (PARP (show PARP1 Antibodies)) cleavage. Taken together, our findings suggest that a combination therapy using PPARgamma ligands and its inhibitor could be a potential therapeutic strategy targeting glioblastom...

4. High concentrations of DINCH urinary metabolites activate human PPAR-gamma.

5. UCP2 (show UCP2 Antibodies) is a key mediator of hypoxia-triggered chemoresistance in non-small cell lung cancer cells via repression of peroxisome proliferator-activated receptor gamma.

6. MERS-CoV S protein (show CDSN Antibodies) binds to DPP4 (show DPP4 Antibodies) to suppress macrophage activation via induction of IRAK-M (show IRAK3 Antibodies), PPARgamma and the immunosuppressive cytokine IL-10 (show IL10 Antibodies).

7. our findings provide novel insights into the role of PPARgamma in inhibiting breast cancer progression

8. these findings identified an important role of renal tubular epithelium-targeted PPAR-gamma in maintaining the normal epithelial phenotype and opposing fibrogenesis, possibly via antagonizing oxidative stress

9. Results demonstrate that phosphorylation of PPARgamma at Ser84 is up-regulated in hepatocellular carcinoma (HCC (show FAM126A Antibodies)) tumors. The study provides the first evidence that the novel roles of PPARgamma are linked to glycolysis by PFKFB4 (show PFKFB4 Antibodies) for the regulation of glycolysis and proliferation in HCC (show FAM126A Antibodies) cells.

10. These results indicated that AKT (show AKT1 Antibodies)-PPARgamma signaling pathway mediated HG-induced lipid deposition by upregulating CD36 (show CD36 Antibodies) expression in HK-2 (show HK2 Antibodies) cells and that inhibition of AKT (show AKT1 Antibodies)-PPARgamma signaling pathway had the potential beneficial effects of reducing lipid deposition in diabetic kidney.

Pig (Porcine) Peroxisome Proliferator-Activated Receptor gamma (PPARG) interaction partners

1. The results of the present study suggested that PPARG may mediate porcine placental angiogenesis, by interfering with hypoxia inducible factor, vascular endothelial growth factor (show VEGF Antibodies) and angiopoietinmediated signaling.

2. The results suggest the higher expression of miR (show MYLIP Antibodies)-130a, which targeting peroxisome proliferator-activated receptor gamma, may be the reason for less fat deposition in intramuscular adipose tissue than subcutaneous adipose tissue.

3. The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR (show FRAP1 Antibodies) and PPARg. In summary, PPARg plays an important role in the regulation of IGF-1 (show IGF1 Antibodies) secretion and gene expression in response to dietary protein.

4. The regulatory role of microRNA miR (show MYLIP Antibodies)-27b-3p on peroxisome proliferator-activated receptor-gamma (PPARgamma) was confirmed by their inversed expression patterns in oocytes: [miR (show MYLIP Antibodies)-27b-3p]

5. an Enhancer box and a binding site for a cooperative co-activator of MyoD (show MYOD1 Antibodies) are present in the promoter region of porcine PPARgamma.

6. The data suggest that there is local cooperation between resistin (show RETN Antibodies) and PPARgamma expression in the porcine ovary. Resistin (show RETN Antibodies) significantly increased the expression of PPARgamma, whereas PPARgamma decreased resistin (show RETN Antibodies) expression; thus, PPARgamma is a new key regulator of resistin (show RETN Antibodies) expression and function.

7. Therefore, this study demonstrated that the different regulatory adipogenic roles of MSTN (show MSTN Antibodies) in ADSCs and MSCs act by differentially regulating PPARgamma and MyoD (show MYOD1 Antibodies) expression.

8. PGRN (show GRN Antibodies) inhibits adipogenesis in porcine preadipocytes partially through ERK (show MAPK1 Antibodies) activation mediated PPARgamma phosphorylation.

9. Resveratrol activated sirtuin 1 (Sirt1 (show SIRT1 Antibodies)) gene expression and increased adipose triglyceride lipase (ATGL (show PNPLA2 Antibodies)) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 (show SIRT1 Antibodies) regulation pattern for PPARgamma to that of ATGL (show PNPLA2 Antibodies) in adipocytes.

10. The results indicate that the endometrial expression of PPARgamma genes fluctuates during the estrous cycle and pregnancy.

Cow (Bovine) Peroxisome Proliferator-Activated Receptor gamma (PPARG) interaction partners

1. Three novel SNPs of the bovine PPARgamma gene were identified in 514 individuals from six Chinese cattle breeds: SNP1 (AC_000179.1 g.57386668 C > G) in intron 2 and SNP2 (AC_000179.1 g.57431964 C > T) and SNP3 (AC_000179.1 g.57431994 T > C) in exon 7.

2. These results indicated that docosahexaenoic acid may attenuate lipopolysaccharide-stimulated inflammatory response in bovine mammary epithelial cells by suppressing NF-kappaB (show NFKB1 Antibodies) activation through a mechanism partly dependent on PPARgamma activation.

3. PPARgamma is a positive regulator of milk fat synthesis in dairy cow mammary epithelial cells.

4. An Asp7Gly substitution in PPARG is associated with adiposity.

5. upregulation of PPARgamma was observed in the backfat tissue of Lilu cattle with increasing age

6. Co-culture of adipocytes and myoblasts elicited an increase in C/EBPbeta (show CEBPB Antibodies) and PPAR-gamma gene expression in differentiated myoblasts and an increase in GPR43 (show FFAR2 Antibodies) gene expression in adipocytes.

7. A potential association of an single nucleotide polymorphism (72472 GT in exon7) of the bovine PPAR-gamma gene with carcass and meat quality traits, was evaluated.

8. study demonstrates the co-expression of DLX3 (show DLX3 Antibodies), PPARG and SP1 (show SP1 Antibodies) in trophoblast binucleated cell(BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation

9. Single nucleotide polymorphisms in coding region of the PPARgamma gene, were examined.

10. oxidative stress attenuates PPAR gamma expression and activity in vascular endothelial cells

Rhesus Monkey Peroxisome Proliferator-Activated Receptor gamma (PPARG) interaction partners

1. study found PPAR-gamma expression was prominent in the subthalamic nucleus, oculomotor nucleus, ventral tegmental nucleus, and to a lesser extent, in the putamen; 3 or 12 months after MPTP (show PTPN2 Antibodies), only the lesioned putamen had increased PPAR-gamma

2. Aleglitazar, a dual PPARalpha (show PPARA Antibodies)/gamma agonist, has beneficial effects on both lipid and glucose parameters in a primate model of the metabolic syndrome.

Rabbit Peroxisome Proliferator-Activated Receptor gamma (PPARG) interaction partners

1. siRNA targeting PPARgamma gene can inhibit adipogenic differentiation of BMSCs and prevent steroid-induced osteonecrosis in rabbit.

2. vitamin E supplementation affords protection by decreasing MMP-1 (show MMP1 Antibodies) and increasing PPARg, GSTa (show GSTa2 Antibodies), and ABCA1 (show ABCA1 Antibodies) levels in aortae of rabbits fed a cholesterol-rich diet

3. Telmisartan improves microvascular dysfunction during myocardial ischemia/reperfusion injury via the PPARgamma pathway.

4. PPARgamma plays a luteotropic role in pseudopregnant rabbits, through PTGS2 (show PTGS2 Antibodies) down-regulation and 3beta-HSD (show HAL Antibodies) up-regulation, with a consequent PGF2alpha decrease and progesterone increase.

5. In an animal model of atherosclerosis, the expression of PPAR-gamma is upregulated following atorvastatin administration.

6. Tongxinluo can inhibit the expression of MMP-3 (show MMP3 Antibodies) and 9 and increase the expression of PPARgamma in atherosclerotic rabbits.

7. Niacin Reduces serum level and adipose mRNA expression of leptin (show LEP Antibodies) and up-regulates PPARgamma and CD36 (show CD36 Antibodies) mRNA expression in hypercholesterolemic rabbits.

8. Antidiabetic drug pioglitazone protects the heart via activation of PPAR-gamma receptors, PI3-kinase (show PIK3CA Antibodies), Akt (show AKT1 Antibodies), and eNOS (show NOS3 Antibodies) pathway in a rabbit model of myocardial infarction.