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Human Polyclonal CYP19A1 Primary Antibody for ICC, IF - ABIN151143
Beyer, Green, Barker, Huskisson, Hutchison: Aromatase-immunoreactivity is localised specifically in neurones in the developing mouse hypothalamus and cortex. in Brain research 1994
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Chicken Polyclonal CYP19A1 Primary Antibody for IHC, WB - ABIN223293
Bukulmez, Hardy, Carr, Word, Mendelson: Inflammatory status influences aromatase and steroid receptor expression in endometriosis. in Endocrinology 2008
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Cow (Bovine) Polyclonal CYP19A1 Primary Antibody for IHC (fro), WB - ABIN549087
Shimizu, Kaji, Murayama, Magata, Shirasuna, Wakamiya, Okuda, Miyamoto: Effects of interleukin-8 on estradiol and progesterone production by bovine granulosa cells from large follicles and progesterone production by luteinizing granulosa cells in culture. in Cytokine 2011
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Human Polyclonal CYP19A1 Primary Antibody for IHC (p), WB - ABIN3044414
Zhang, Zhang, Zhang, Lu, Li, Cui: MiRNA-143 mediates the proliferative signaling pathway of FSH and regulates estradiol production. in The Journal of endocrinology 2017
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Rat (Rattus) Polyclonal CYP19A1 Primary Antibody for IHC (p), WB - ABIN3044490
Zhao, Tian, Hao, Chen: Extragonadal aromatization increases with time after ovariectomy in rats. in Reproductive biology and endocrinology : RB&E 2006
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Human Polyclonal CYP19A1 Primary Antibody for ELISA, WB - ABIN543830
dos Santos, de Jesus, Trindade Filho, Trindade, de Camargo, Rainho, Rogatto: PSA and androgen-related gene (AR, CYP17, and CYP19) polymorphisms and the risk of adenocarcinoma at prostate biopsy. in DNA and cell biology 2008
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Human Polyclonal CYP19A1 Primary Antibody for IHC (fro), ELISA - ABIN543933
Xita, Georgiou, Lazaros, Psofaki, Kolios, Tsatsoulis: The synergistic effect of sex hormone-binding globulin and aromatase genes on polycystic ovary syndrome phenotype. in European journal of endocrinology / European Federation of Endocrine Societies 2008
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Human Polyclonal CYP19A1 Primary Antibody for IHC (p), WB - ABIN391826
Licznerska, Szaefer, Wierzchowski, Sobierajska, Baer-Dubowska: Resveratrol and its methoxy derivatives modulate the expression of estrogen metabolism enzymes in breast epithelial cells by AhR down-regulation. in Molecular and cellular biochemistry 2017
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Polyclonal CYP19A1 Primary Antibody for WB - ABIN540749
Bogan, Murphy, Stouffer, Hennebold: Systematic determination of differential gene expression in the primate corpus luteum during the luteal phase of the menstrual cycle. in Molecular endocrinology (Baltimore, Md.) 2008
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Human Polyclonal CYP19A1 Primary Antibody for IF (p), IHC (p) - ABIN725150
Qu, Liang, Zhou, Ma, Zhou, Wang, Wu, Fang: Transcutaneous electrical acupoint stimulation alleviates the hyperandrogenism of polycystic ovarian syndrome rats by regulating the expression of P450arom and CTGF in the ovaries. in International journal of clinical and experimental medicine 2015
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Liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis revealed that aromatase is basally acetylated on several lysine residues (108, 169, 242, 262, 334, 352, and 354) in MCF-7 cells, and treatment with a SIRT-1 inhibitor induced additional acetylation (376, 390, 440, and 448). These acetylated lysine residues are in regions critical for aromatase (CYP19A1)activity
There was an additive effect of the alleles in the four genes associated with good growth response. For rs3110697 within IGFBP3, rs1045992 in CYP19A1 and rs2888586 in SOS1, the variant associated with better growth response showed higher transcriptional activity with r-hGH treatment
High CYP19A1 expression is associated with Aromatase excess syndrome.
CYP19A1 promotes cholangiocarcinoma progression with aggressive clinical outcomes via increased migration and proliferation activities of cancer cells.
CYP19A1 SNPs are significantly associated with the risk for adenomyosis.
the inducing effect of kisspeptin on aromatase expression is possibly mediated via kisspeptin receptor and estrogen receptor dependent mechanisms
A novel CTBP1/CYP19A1/Estradiol axis that explains, in part, the mechanism for prostate tumor growth increase by MeS.
Metformin could down-regulate the mRNA expression level of aromatase in the uterine leiomyoma cells. These results indicate that metformin may inhibit the local estrogen synthesis and therefore suppress the development of uterine leiomyoma.
we evaluated the frequencies of CYP19A1 rs2414096 and DENND1A rs10818854 polymorphisms in overweight and normal individuals and didn't find any significant difference between these groups which demonstrates a lack of association between obesity risk and these SNPs
this study shows that elevated CYP19A1 expression is associated with a poor survival of patients with estrogen receptor positive breast cancer
These findings suggest that reduced SIRT1-mediated deacetylation of HIF-1alpha contributes to the elevated levels of aromatase in breast tissues of obese women.
Study results demonstrate that aromatase expression in tumor related stroma but not tumor epithelium may play a critical role in human bladder cancer progression.
Patients with the variant homozygous genotype AA of CYP19A1 (rs10046) showed increased serum concentrations of estradiol when compared to patients with other genotypes (p = 0.005). The CYP19A1 variant is associated with an estradiol imbalance in serum. This CYP19A1 variant did not affect the number of oocytes recovered nor their maturation level.
rs727479 associated with recurrent spontaneous abortions
Investigated aromatase regulation by leptin involving the p53-HIF1alpha/PKM2-aromatase axis and studied in situ, the association of BMI and the breast ASC-specific immunoreactivity of members of the p53-HIF1alpha/PKM2-aromatase axis.
The TT genotype of rs700518 is an independent risk factor for the of benign prostate hyperplasia (BPH) is combined with metabolic syndrome population
CYP19A1 mRNA levels were lower in endometrial cancer (EC) than in controls. A novel highly sensitive and accurate protocol to assess SULT1E1 activity is presented. STS enzyme activity and the STS:SULT1E1 activity ratio seem to be lower in ECs than in controls. STS is an important route for estrogen supply in endometrial cells.
Though the CYP19A1 rs7176005 SNP is not associated with breast cancer development, breast cancer patients with the C allele exhibit a high tumor growth rate and large diameters.
The authors demonstrated in vitro that neonicotinoids may stimulate a change in CYP19 promoter usage similar to that observed in patients with hormone-dependent breast cancer.
IL-10 suppresses TNF-alpha-induced expression of human aromatase gene in mammary adipose tissue.
We found that cyp19a1 expression is highly regionalized in the brains of both sexes.
Cyp19a1 expression leads to female sex determination in Xenopus laevis.
brain-specific promoter/exon I.f of the cyp19a1 has cis-elements for several transcriptional factors
binding sequences to a specific trans-activating factor upstream of the p450 aromatase promoter II
The ontogenetic patterns of Aro, Srd5a1 and Srd5a2 suggest that these genes are involved in sexual differentiation of gonads and brain already in early developmental stages.
co-localization of estrogen receotirs with aromatase in horse trophoblast suggests auto- or intracrine functions of oestrogens in this cell type
CYP19A1 is an inhibitor of follicular atresia and is regulated by both SMAD4 and miR-10b.
liver receptor homolog (LRH)-1, not CYP19A1, is a direct functional target of miR-1275.
CYP19A1 is involved in sperm fertility and its expression in sperm plays an important role in fertilization.
P450arom was expressed in all layers of the arterial and venous vessels of the spermatic cord with higher intensity of staining in June long daylight) compared to December(short daylight).
Decreased estradiol production via suppression of aromatase may be one of the mechanisms by which miR-378 regulates the maturation of cumulus-oocyte complexes.
This study tested whether prenatal and neonatal exposure to antiandrogen flutamide affected ovarian 17beta-estradiol synthesis and the associated gene expression in large antral follicles of adult pigs.
show that micro-RNA378 (miR-378) is spatiotemporally expressed in porcine granulosa cells, the cells that generate estradiol in the ovary during follicular development, in an inverse manner compared with the expression of aromatase
Pig ejaculated spermatozoa express aromatase.
The presence of aromatase and 11beta-HSD 2 in Leydig cells increased, together with germ and Sertoli cell numbers.
This study demonstrates that transferrin had a dose-dependent inhibitory effect on follicle stimulating hormone-stimulated aromatase activity.
In conclusion, sex chromosome complement governs the hormonal regulation of aromatase expression through activation of ERbeta in developing mouse brain.
This study demonstrated that Aromatase expression in spinal cord and medulla in sex difference.
These studies suggest an association between adiposity, aromatase estrogenic capacity and atrial arrhythmogenicity.
Increased adipose tissue aromatase activity reduces adipose tissue inflammation and improves insulin sensitivity in male mice.
Aromatase-knockout (ArKO) mice cannot synthesize estrogens in vivo. Male ArKO mice developed hepatic steatosis accompanied by high testosterone levels.
results show that the Aha1-Hsp90-PKM2/HIF-1alpha axis mediates the induction of aromatase in Li-Fraumeni Syndrome.
aromatase could modulate pituitary LH-positive cells in males through local estradiol synthesis.
Findings indicate that sex chromosome factors determine sex differences in aromatase expression in the stria terminalis and in the anterior amygdaloid area of mouse embryos.
CELF1 downregulates Cyp19a1 (Aromatase) posttranscriptionally to achieve high concentrations of testosterone compatible with spermiogenesis completion.
Aromatase plays an important role in the survival of metastatic ERalpha breast cancer cells by suppressing anoikis.
aromatase may play a key role in the pathogenesis of Sjogren syndrome-like lesions by controlling the target organ and adipose tissue-associated macrophage; increased MPC1 protein expression has a role in adiposity
The protective effect of female gender on abdominal aortic aneurysms is due to estrogen synthesis and requires the presence of both ovarian and extragonadal/peripheral aromatase.
Aromatase signaling is common in the mouse brain; locally synthesized brain estrogens could mediate biological effects by activating pre- and post-synaptic estrogen alpha and beta receptors, and androgen receptors.
Male Aromatase knockout mice develop hepatic glucose intolerance.
Cerebrovascular endothelial aromatase plays an important and sexually dimorphic role in cerebrovascular function and that aromatase inhibitors in clinical use may have cardiovascular consequences in both males and females.
CYP19A1 gene is driven by promoters PII, I.4, and I.3 in the seminal vesicles, and by promoters PII and I.4 in the urinary bladder.
Lhx2 is involved in the transcriptional regulation of aromatase in the rodent brain.
Glucocorticoids alter aromatase expression in the hypothalamus and might regulate gonadotropin pulses and the menstrual cycle.
Aromatase-deficient mice displayed increased cortical neuronal density and occasional cortical heterotopias
Data show that the human aromatase gene can be expressed via its native promoters in a wide variety of mouse tissues and in a distribution pattern nearly identical to that of humans.
This study examined the calibration of follicular development in chickens and cattle according to gene expression patterns. Unlike mammals, ESR2 was implicated as one of transcription factors regulating CYP19A1 expression in chicken follicles.
The CYP19A1 gene contributes to genetic variation of in vitro embryo production traits in cattle. The complexity of the physiological phenomena related to estrogen pathways and their influence on reproduction in cattle allow indication of the mutations evaluated here as possible genetic markers for embryo production traits, which should be validated in the next steps of marker-assisted selection.
in granulosa cells of dominant follicles the concentration of CYP19P1 mRNA was very low compared to CYP19A1 mRNA. CONCLUSIONS: CYP19P1 and CYP19A1 transcripts might interfere in placental cotyledons
These data suggest that a major reason why CYP19A1 is not expressed in luteinized cells (and the corpus luteum) of ruminants may be the stimulatory effect of FOXL2, which does not appear to be the case in the human and rat.
This study evaluated the relationships among aromatase, IGF-1, IGF2R, and FSH levels expressed in ovarian follicles of cattle selected for twin pregnancies.
Data indicated de novo DNA methylation fter the luteinizing hormone-induced down-regulation of CYP19A1 expression, suggesting that DNA methylation might play a role for permanent silencing of previously down-regulated genes.
P450(AROM) is localized in the cytoplasm and only seldom present in the fine extensions of the cells in frontal cortex.
Granulosa and theca of well-characterized large bovine follicles were isolated before and after the LH surge. CYP19A1, HSD3B1, and CYP17A1 transcripts were quantified by real-time PCR (qPCR) and the chromatin condensation was determined.
DNA methylation may have a role in the permanent shutdown of promoter 2-directed cytochrome P450 19A1(CYP19A1) expression in large (granulosa derived) lutein cells
fetal ovary of cattle has the steroidogenic enzyme aromatase to convert androgens to estradiol-17beta, and estrogen receptors alpha and beta to facilitate an estrogen response within the fetal ovary
granulosa cell clustering is accompanied by marked increases in FSHr, IGF-1r, and p450 arom expression, and precedes induction and subsequent peak E2 production
demonstrates that cattle and sheep use different promoters to direct aromatase(Cyp19) expression during pregnancy
Promoter-2-derived high-level expression of Cyp19 might be controlled by cell-type-specific DNA methylation.
CYP19 is regulated by multiple pathways in granulosa cells
second quarter of the gestation is the developmental stage which represents a critical period for hypothalamic differentiation in bovine ontogenesis.
Serum free culture conditions significantly enhanced Cyp17 and Csh1 but not Hsd3b expression in trophoblast.
CYP19 promoters are differentially methylated in ovine and bovine placental tissues of foetal and maternal origin.
Administration of CART in vivo into follicles at the early dominance stage reduced follicular fluid estradiol concentrations and granulosa cell CYP19A1 mRNA.
The CYP19/PvuII allele frequencies were as follows: A -0.91 and B -0.09. The highest average heterozygosity rate was found in herd A (0.2108).
Relative mRNA expression for insulin and FSH receptors and cytochrome P450 aromatase in cultured follicles.
cyp19a1a is expressed early during development, before the histological differentiation of the gonads, and the down-regulation of cyp19a1a expression is likely responsible for the testicular differentiation.
Knocking down the expression of gdf9 and cyp19a1a with vivo-morpholinos caused a male-skewed sex ratio.
Mutant zebrafish lines lacking the ovarian aromatase gene (cyp19a1a) leads to all-male offspring, suggesting that aromatase plays a critical role in directing ovarian differentiation and development.
Dual functions of the cyp19a1a gene during sex differentiation: cyp19a1a is not only indispensable for female sex differentiation but also required for male sex differentiation.
The whole-body androgen levels, follicle-stimulating hormone beta and luteinizing hormone beta protein levels in the pituitary, and transcript levels of genes known to be involved in spermatogenesis and steroidogenesis in the testes were significantly higher in the cyp19a1a mutant and aromatase double-mutant males than in the wild-type and cyp19a1b mutant male.
The results from the present study strongly suggest that DNA methylation is one of mechanisms that is involved in the regulation of cyp19a1a gene expression during folliculogenesis
Data show that cytochrome P450 enzymes Cyp17-I, Cyp11c1, Cyp19a1a and Cyp19a1b and one of their regulators forkhead protein Foxl2a were detected both in the testis and ovary.
Data indicate taht monocrotophos (MCP) exposure modulated gene expression of forkhead transcription factor gene L2 (foxl2), doublesex/mab-3 related transcription factor 1 (dmrt1), gonadal aromatase (cyp19a1a) and brain aromatase (cyp19a1b).
The differential expression of the aromatase genes, particularly CYP19A2 in the brain, suggests that the two aromatase genes play different roles in the reproductive behavior and/or physiology of bony fish.
zebrafish Anti-Mullerian hormone (Amh) is regulated by sox9a, sox9b, and cyp19a1a during gonad development
These results demonstrate seasonal and sex differences in brain aromatase mRNA expression in a teleost fish and suggest a role for aromatase in the expression of vocal-acoustic and alternative male reproductive phenotypes.
These analyses suggest that variants of CYP19 are not associated with risk of breast cancer.
amh is a candidate gene down-regulating cyp19a1a, leading to "juvenile ovary-to-testis" transformation.
two mutants with premature stops in the ovarian aromatase (cyp19a1) gene from an N-ethyl-N-nitrosourea-based gene-driven mutagenesis library of the medaka, Oryzias latipes, were isolated.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity\; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants.
, cytochrome P-450AROM
, cytochrome P450 19A1
, cytochrome P450, subfamily XIX (aromatization of androgens)
, estrogen synthase
, estrogen synthetase
, flavoprotein-linked monooxygenase
, microsomal monooxygenase
, Cytochrome P450, 19, aromatase
, cytochrome P450 family 19 subfamily a
, cytochrome P450, subfamily 19
, p450 aromatase A
, cytochrome P450 aromatase
, cytochrome P450 17-alpha
, cytochrome P450 19 type I
, cytochrome P450, family19, subfamily A, polypeptide 1
, cytochrome P450, 19, aromatase
, cytochrome P450, family XIX (conversion of androgen to estrogen), aromatase
, Cytochrome P-450AROM
, Cytochrome P450 19A1
, Estrogen synthase
, aromatase cytochrome P450
, cytochrome P450 19A1a
, cytochrome P450, 19a
, P-450 aromatase
, cytochrome P-450 aromatase