Aromatase antibody (C-Term)

Catalog No. ABIN391826

Product Details anti-Aromatase Antibody

Target: Aromatase (CYP19A1) (Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1))

Binding Specificity: AA 453-485, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Aromatase antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This Aromatase (CYP19A1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 453-485 amino acids from the C-terminal region of human Aromatase (CYP19A1).

Clone: RB14708

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze-thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Expiry Date: 6 months

References for anti-Aromatase antibody (ABIN391826)

Ding, Li, Wang, Wang, Wu, Chen, Lv, Wang, Huang: "Different therapeutic effects of cells derived from human amniotic membrane on premature ovarian aging depend on distinct cellular biological characteristics." in: Stem cell research & therapy, Vol. 8, Issue 1, pp. 173, (2018) (PubMed).

Licznerska, Szaefer, Wierzchowski, Sobierajska, Baer-Dubowska: "Resveratrol and its methoxy derivatives modulate the expression of estrogen metabolism enzymes in breast epithelial cells by AhR down-regulation." in: Molecular and cellular biochemistry, Vol. 425, Issue 1-2, pp. 169-179, (2017) (PubMed).

Target Details for Aromatase

Target: Aromatase (CYP19A1) (Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1))

Alternative Name: Aromatase (CYP19A1) (CYP19A1 Products)

Background: CYP19A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in the gene encoding CYP19A1 can result in either increased or decreased aromatase activity, the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation.

Molecular Weight: 57883

Gene ID: 1588

NCBI Accession: NP_000094, NP_112503

UniProt: P11511

Pathways: Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, C21-Steroid Hormone Metabolic Process, Carbohydrate Homeostasis