Browse our PHGDH Proteins (PHGDH)

Full name:: phosphoglycerate Dehydrogenase Proteins (PHGDH)

On www.antibodies-online.com are 11 phosphoglycerate Dehydrogenase (PHGDH) Proteins from 5 different suppliers available. Additionally we are shipping PHGDH Antibodies (133) and PHGDH Kits (10) and many more products for this protein. A total of 164 PHGDH products are currently listed.

Synonyms:: 3-PGDH, 3PGDH, 4930479N23, A10, ECK2909, embryo sac development arrest 9, F10M10.7, fb38f06, JW2880, PDG, PGAD, PGD, PGDH, SERA, wu:fb38f06, zgc:65956

list all proteins	Gene Name	GeneID	UniProt
	PHGDH	236539	Q61753
	PHGDH	26227	O43175
	PHGDH	58835	O08651
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PHGDH Proteins (PHGDH) by Origin

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Relevant Pathways for PHGDH Proteins

Metabolism of Steroid Hormones and Vitamin D

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More Proteins for PHGDH Interaction Partners

Arabidopsis thaliana phosphoglycerate Dehydrogenase (PHGDH) interaction partners

PGDH1 (show HPGD Proteins) is essential for Arabidopsis development.
Genetic and molecular evidence were provided for the essential role of EDA9 for embryo and pollen development.
Data indicate that 3-phosphoglycerate dehydrogenases PGDH (show HPGD Proteins) (At1g17745) and EDA9 (At4g34200) were expressed preferentially in roots while 3-PGDH (At3g19480) was expressed mainly in the aerial parts and was not expressed or very poorly in roots.

Mouse (Murine) phosphoglycerate Dehydrogenase (PHGDH) interaction partners

These results indicate that the PHGDH gene expression, dictated by IL-2R signaling, is a crucial event for DNA synthesis during S phase of activated T cells.
Using transgenic mice expressing enhanced GFP under the Srr (show SRR Proteins) promoter and mice with targeted deletion of Srr (show SRR Proteins) or 3-Phosphoglycerate dehydrogenase, we demonstrate predominantly neuronal sources of d-serine dependent on astrocytic supply of l-serine.
Elevated levels of 4E-BP1 (show EIF4EBP1 Proteins) may be involved in a mechanism to arrest brain development in Phgdh knock out embryos.
Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of brain D-serine, an N-methyl-D-aspartate receptor (show GRIN1 Proteins) co-agonist
Data suggest expression of Phgdh in endometrium is regulated by Hoxa10.
the Phgdh-dependent phosphorylated pathway is essential for normal embryonic development, especially for brain morphogenesis
the presence of cis (show CISH Proteins)-acting elements confer the cell type specificity of Phgdh transcription in the distal promoter region.
The mouse Phgdh gene spans approximately 27 kilobases in length and comprises 12 exons with 11 intervening introns and is mapped to chromosome 3, region F2-F3 by FISH.
either Phgdh or ASCT1 (show SLC1A4 Proteins) is provided to each segment of renal tubules, suggesting that metabolic interplay mediated by L-serine biosynthesis and supply may exist in the kidney
Inactivation of Phgdh gene with changes in gene expression and associated regulatory networks resulting from serine deficiency are reported.

Human phosphoglycerate Dehydrogenase (PHGDH) interaction partners

Study provides evidence that a unique metabolic program is activated in a lung adenocarcinoma subset, described by PHGDH, which confers cell growth.
Data indicate that the expression of PHGDH is increased in pancreatic cancer and is an independent molecular prognostic factor for pancreatic cancer patients. In addition, PHGDH controls cell proliferation, migration and invasion abilities.
Data show there was a significant negative correlation between PHGDH copy-number alteration and EPAS1 (HIF2A (show EPAS1 Proteins)) expression.
Therefore, we show for the first time that the nuclear localization of Cat L and its substrate Cux1can be positively regulated by Snail NLS and importin beta1, suggesting that Snail, Cat L and Cux1 all utilize importin beta1 for nuclear import.
High PHGDH expression is associated with idiopathic pulmonary fibrosis.
This report present 6 individuals from 3 unrelated families with infantile serine biosynthesis defect due to PGDH (show HPGD Proteins) deficiency.
Overexpression of Phgdh may be generally associated with CK5 (show KRT5 Proteins) cells, and oncogenic function may be determined by isoform expression.
High expression of PHGDH is associated with Colon Cancer.
p53 (show TP53 Proteins)-mediated repression of PHGDH enhances the apoptotic response upon serine starvation in melanoma cells.
Phosphoglycerate Dehydrogenase deficiency is associated with Neu-Laxova syndrome.

PHGDH Protein Profile

Protein Summary

This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known.

Alternative names and synonyms associated with PHGDH

phosphoglycerate dehydrogenase (phgdh)
D-3-phosphoglycerate dehydrogenase (EDA9)
D-3-phosphoglycerate dehydrogenase (serA)
D-3-phosphoglycerate dehydrogenase (Sthe_2284)
D-3-phosphoglycerate dehydrogenase (Dacet_1260)
D-3-phosphoglycerate dehydrogenase (Mrub_0173)
phosphoglycerate dehydrogenase (MMAH_RS07650)
D-3-phosphoglycerate dehydrogenase (Arnit_0487)
D-3-phosphoglycerate dehydrogenase (Ndas_0174)
D-3-phosphoglycerate dehydrogenase (Mesil_2386)
D-3-phosphoglycerate dehydrogenase (Slip_0010)
D-3-phosphoglycerate dehydrogenase (Trad_0302)
D-3-phosphoglycerate dehydrogenase (Acear_0027)
D-3-phosphoglycerate dehydrogenase (Mahau_0665)
phosphoglycerate dehydrogenase (MZHIL_RS05165)
D-3-phosphoglycerate dehydrogenase (Mesop_1331)
D-3-phosphoglycerate dehydrogenase (Thein_0855)
3-phosphoglycerate dehydrogenase (Phgdh)
phosphoglycerate dehydrogenase (PHGDH)
phosphoglycerate dehydrogenase (Phgdh)

3-PGDH protein
3PGDH protein
4930479N23 protein
A10 protein
ECK2909 protein
embryo sac development arrest 9 protein
F10M10.7 protein
fb38f06 protein
JW2880 protein
PDG protein
PGAD protein
PGD protein
PGDH protein
SERA protein
wu:fb38f06 protein
zgc:65956 protein

Protein level used designations for PHGDH

D-3-phosphoglycerate dehydrogenase , 3-phosphoglycerate dehyrogenase , 3-phosphoglycerate dehydrogenase , 3-PGDH

GENE ID	SPECIES
321928	Danio rerio
829568	Arabidopsis thaliana
945258	Escherichia coli str. K-12 substr. MG1655
8639711	Sphaerobacter thermophilus DSM 20745
8875608	Denitrovibrio acetiphilus DSM 12809
8878240	Meiothermus ruber DSM 1279
8983712	Methanohalophilus mahii DSM 5219
9170634	Arcobacter nitrofigilis DSM 7299
9244005	Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111
9251902	Meiothermus silvanus DSM 9946
9272777	Syntrophothermus lipocalidus DSM 12680
9279275	Truepera radiovictrix DSM 17093
9512008	Acetohalobium arabaticum DSM 5501
10607400	Mahella australiensis 50-1 BON
10822643	Methanosalsum zhilinae DSM 4017
10825145	Mesorhizobium opportunistum WSM2075
10841100	Thermodesulfatator indicus DSM 15286
236539	Mus musculus
26227	Homo sapiens
58835	Rattus norvegicus
100144529	Sus scrofa
505103	Bos taurus
739534	Pan troglodytes

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