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anti-Mouse (Murine) ROCK1 Antibodies:
anti-Rat (Rattus) ROCK1 Antibodies:
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Dog (Canine) Monoclonal ROCK1 Primary Antibody for ICC, IF - ABIN252549
Zhao, Miller, Pfeiffer, Buras, Stahl: Anoxia and reoxygenation of human endothelial cells decrease ceramide glucosyltransferase expression and activates caspases. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003
Show all 4 Pubmed References
Human Polyclonal ROCK1 Primary Antibody for ICC, IF - ABIN152055
Chang, Xie, Shah, Schneider, Entman, Wei, Schwartz: Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis. in Proceedings of the National Academy of Sciences of the United States of America 2006
Show all 3 Pubmed References
Human Monoclonal ROCK1 Primary Antibody for ELISA, WB - ABIN969563
Kroll, Epting, Kern, Dietz, Feng, Hammes, Wieland, Augustin: Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis. in American journal of physiology. Heart and circulatory physiology 2009
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Human Polyclonal ROCK1 Primary Antibody for IF (p), IHC (p) - ABIN707771
Wang, Zhang, Wang, Zhang, Mao, Zhuang, Tang, Luo, Zhou, Zhang: Vascular endothelial growth factor stimulates endothelial differentiation from mesenchymal stem cells via Rho/myocardin-related transcription factor--a signaling pathway. in The international journal of biochemistry & cell biology 2013
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Human Monoclonal ROCK1 Primary Antibody for IF, ELISA - ABIN562671
Gong, Fang, Peng, Liu, Du: Integration of virtual screening with high-throughput screening for the identification of novel Rho-kinase I inhibitors. in Journal of biotechnology 2010
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Human Monoclonal ROCK1 Primary Antibody for WB - ABIN223244
Dasgupta, Argaiz, Mercado, Maul, Garza, Enriquez, Abdel-Monem, Prakasam, Andreeff, Thiagarajan: Platelet senescence and phosphatidylserine exposure. in Transfusion 2010
polarity-induced spatiotemporal control of Rok and Pkn (show PKN1 Antibodies) is important for unequal cortical expansion, ensuring correct cleavage furrow positioning and the establishment of physical asymmetry.
Loss of DRok function in tendon cells results in mis (show AMH Antibodies)-orientation of tendon cell extensions and abnormal accumulation of Thrombospondin and betaPS-integrin, which may cause abnormal myotendinous (show TNC Antibodies) junction formation and muscle morphogenesis.
model in which Rok-induced phosphorylation of residues within the basic region mediates the activation of FHOD1 (show FHOD1 Antibodies) homolog Knittrig in controlling macrophage migration
Atonal and EGFR (show EGFR Antibodies) signalling orchestrate rok- and Drak-dependent adherens junction remodelling during ommatidia morphogenesis.
The structure of Shrm (show SHROOM3 Antibodies) domain 2 (SD2), which mediates the interaction with Rock and is required for Shrm (show SHROOM3 Antibodies) function, is reported.
Data show that that Drak broadly promotes proper morphogenesis of epithelial tissues during development, and Drak activity is largely redundant with that of the Drosophila ROCK orthologue, Rok.
CD44 (show CD44 Antibodies) interaction with p115RhoGEF (show ARHGEF1 Antibodies) and ROK plays a pivotal role in promoting Gab-1 phosphorylation leading to Gab-1.PI 3 (show PI3 Antibodies)-kinase membrane localization, AKT (show AKT1 Antibodies) signaling, and cytokine (M-CSF (show CSF1R Antibodies)) production during HA-mediated breast cancer progression
Drok and Drosophila Lim (show ZYX Antibodies)-kinase interact in the developing nervous system
DRok is required for tissue morphogenesis in diverse compartments of the egg chamber during oogenesis
activation of RhoA/ROCK and PI3K/Akt plays a pivotal role in leptin signaling, leading to the development of VSMC hypertrophy through a mechanism involving altered actin dynamics
A specific inhibitor of ROCK, Y-27632, was used to examine the role of ROCK in mouse colitis models. ROCK1 and ROCK2 (show ROCK2 Antibodies) were silenced respectively using RNA interference in Caco-2 cells. The expression of tight junction proteins and the downstream molecules of ROCK were assessed
GTP (show AK3 Antibodies)-RhoA (show RHOA Antibodies) and ROCK1 expression levels were markedly increased in a time-dependent manner in the ears and lungs of mice treated with penicillin.
Irisin (show FNDC5 Antibodies) replenishment in mCaROCK1 mice partially reversed insulin (show INS Antibodies) resistance.
MicroRNA-146a suppresses ROCK1 allowing hyperphosphorylation of tau in Alzheimer's disease
Fasudil exhibited protective effects on smoke exposure induced cognitive deficits which might involve with the regulation of Rho/ROCK/NF-kappaB (show NFKB1 Antibodies) pathways.
we define how ROCK/LIMK (show LIMK1 Antibodies) pathway regulates mast cell development and functions
Dexamethasone up-regulates ROCK1/2 activity promoting migration, invasion and metastasis of melanoma cells.
mDia induces circumferential actin filaments around the edge of the synaptic cleft, which contract the presynaptic terminals in a ROCK-dependent manner.
SNRK (show SNRK Antibodies) in cardiomyocytes is responsible for maintaining cardiac metabolic homeostasis, which is mediated in part by ROCK, and alteration of this homeostasis influences cardiac function in the adult heart.
we uncovered cell state plasticity and adhesion dynamics regulated by Ror2 (show ROR2 Antibodies), which influenced Ras Homology Family Member A (show CXCL14 Antibodies) (RhoA (show RHOA Antibodies)) and Rho-Associated Coiled-Coil Kinase 1 (ROCK1) activity downstream of Dishevelled-2 (Dvl2 (show DVL2 Antibodies)).
The underlying molecular mechanism of dasatinib-induced reorganization of the actin involves ROCK activation, which increases the amount of the phosphorylation of myosin light chain and consequently activates the non-muscle myosin II.
NEAT1 promoted ovarian cancer cells metastasis through regulating the miR (show MLXIP Antibodies)-382-3p/ROCK1 axis
Data demonstrate that miR (show MLXIP Antibodies)-148a acts as a tumor suppressor in OS, at least partly, via targeting ROCK1.
We identify HGF (show HGF Antibodies), acting through the c-Met receptor, as the key polarity-inducing morphogen (show SHH Antibodies), which acts to activate b1-integrin-dependent adhesion. HGF (show HGF Antibodies) and ECM (show MMRN1 Antibodies)-derived integrin signals co-operate via a c-Src (show SRC Antibodies)-dependent inhibition of the RhoA (show RHOA Antibodies)-ROCK1 signalling pathway via p190A (show GRLF1 Antibodies) RhoGAP (show ARHGAP1 Antibodies)
data suggest that TGF-beta (show TGFB1 Antibodies) stimulated the expression of ChPF (show CHPF Antibodies) and sGAG synthesis in nucleus pulposus cells through Smad3 (show SMAD3 Antibodies), RhoA (show RHOA Antibodies)/ROCK1 and the three MAPK (show MAPK1 Antibodies) signaling pathways.
RhoA (show RHOA Antibodies) is activated in tumors from neuroblastoma (show ARHGEF16 Antibodies) patients, and elevated expression of Rho-associated kinase (ROCK)2 (show ROCK2 Antibodies) is associated with poor patient survival. Pharmacological or genetic inhibition of ROCK1 and 2, key molecules in Rho signaling, resulted in neuroblastoma (show ARHGEF16 Antibodies) cell differentiation and inhibition of neuroblastoma (show ARHGEF16 Antibodies) cell growth, migration, and invasion.
Knockdown of ROCK1 decreased the volume and weight of the xenograft tumors, while overexpression of ROCK1 showed a proliferative tendency with significantly greater tumor volume and weight in vivo. The upregulation of ROCK1 increased the expression of MMP-9 (show MMP9 Antibodies), and levels of MMP-9 (show MMP9 Antibodies) positively correlated with the ROCK1 levels in PTC (show F9 Antibodies) tissues.
ROCK1 and ROCK2 (show ROCK2 Antibodies) contribute to the genetic susceptibility of hypertension and stroke.
Our findings revealed that ROCK1 was overexpressed in malignant vascular tumors such as hemangioendotheliomas and angiosarcomas, and ROCK2 (show ROCK2 Antibodies) was overexpressed in both benign and malignant vascular tumors including hemangiomas, hemangioendotheliomas, hemangiopericytomas, and angiosarcomas. shRNA-mediated knockdown of ROCK2 (show ROCK2 Antibodies), but not ROCK1, in xenograft vascular tumors significantly reduced tumor size and proliferative index
MicroRNA-146a suppresses ROCK1 allowing hyperphosphorylation of tau in Alzheimer's disease.
Results indicate that ROCK1 and ROCK2 (show ROCK2 Antibodies) may exert different biological functions during the regulation of compaction and in ensuring development of porcine preimplantation embryos to the blastocyst stage.
It is highly possible that Rho-kinase plays an important role in the pathogenesis of in-stent restenosis. Rho-kinase is not involved in endothelial regeneration after vascular injury.
results suggest that the ROCK/MLC/actomyosin as well as ROCK/LIMK (show LIMK1 Antibodies)/cofilin (show CFL1 Antibodies) pathways regulate meiotic spindle migration and cytokinesis during bovine oocyte maturation.
In airway smooth muscle, muscle contraction involves the translocation of ROCK1 from non-caveolar to caveolar regions.
p38 (show MAPK14 Antibodies) phosphorylation and MMP13 (show MMP13 Antibodies) expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.
The RhoA (show RHOA Antibodies)/ROCK signaling pathway is an important negative regulator of vascular calcification.
caveolar and cholesterol integrity are indispensable for the proper functionality of the H(1) and 5-HT(2A) receptors through their Rho/ROCK signaling.
A functional contribution of PI3K, Rho, and ROCK to both the autocrine mechanism of ATP release and ATP-mediated angiogenic activation of vasa (show DDX4 Antibodies) vasorum endothelial cells, is reported.
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.
Rho-associated coiled coil containing protein kinase 1
, rho-associated protein kinase 1
, Rho-associated, coiled-coil containing protein kinase 1
, Rho-associated kinase
, RhoA kinase
, drosophila rho-associated kinase
, rho kinase
, Rho-associated coiled-coil forming kinase 1
, p160 ROCK-1
, rho-associated, coiled-coil-containing protein kinase 1
, rho-associated, coiled-coil-containing protein kinase I
, Rho-associated kinase beta
, liver regeneration-related protein LRRG199
, p150 RhoA-binding kinase ROK beta
, Rho kinase
, renal carcinoma antigen NY-REN-35
, cAMP-dependent protein kinase ROCK-I
, corneal epithelial Rho-associated-Ser/Thr kinase 1
, Rho-kinase beta
, Rho-associated protein kinase 1
, rho-associated coiled-coil domain-containing protein kinase 1