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anti-Mouse (Murine) ROCK1 Antibodies:
anti-Rat (Rattus) ROCK1 Antibodies:
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Human Monoclonal ROCK1 Primary Antibody for IF, WB - ABIN968386
Ishizaki, Maekawa, Fujisawa, Okawa, Iwamatsu, Fujita, Watanabe, Saito, Kakizuka, Morii, Narumiya: The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase. in The EMBO journal 1996
Show all 5 Pubmed References
Human Monoclonal ROCK1 Primary Antibody for IF, WB - ABIN968387
Nakagawa, Fujisawa, Ishizaki, Saito, Nakao, Narumiya: ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. in FEBS letters 1996
Show all 5 Pubmed References
Dog (Canine) Monoclonal ROCK1 Primary Antibody for ICC, IF - ABIN252549
Zhao, Miller, Pfeiffer, Buras, Stahl: Anoxia and reoxygenation of human endothelial cells decrease ceramide glucosyltransferase expression and activates caspases. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003
Show all 4 Pubmed References
Human Polyclonal ROCK1 Primary Antibody for ICC, IF - ABIN152055
Chang, Xie, Shah, Schneider, Entman, Wei, Schwartz: Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis. in Proceedings of the National Academy of Sciences of the United States of America 2006
Show all 3 Pubmed References
Human Monoclonal ROCK1 Primary Antibody for ELISA, WB - ABIN969563
Kroll, Epting, Kern, Dietz, Feng, Hammes, Wieland, Augustin: Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis. in American journal of physiology. Heart and circulatory physiology 2009
Show all 2 Pubmed References
Human Polyclonal ROCK1 Primary Antibody for IF (p), IHC (p) - ABIN707771
Wang, Zhang, Wang, Zhang, Mao, Zhuang, Tang, Luo, Zhou, Zhang: Vascular endothelial growth factor stimulates endothelial differentiation from mesenchymal stem cells via Rho/myocardin-related transcription factor--a signaling pathway. in The international journal of biochemistry & cell biology 2013
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Human Monoclonal ROCK1 Primary Antibody for IF, ELISA - ABIN562671
Gong, Fang, Peng, Liu, Du: Integration of virtual screening with high-throughput screening for the identification of novel Rho-kinase I inhibitors. in Journal of biotechnology 2010
Show all 2 Pubmed References
Human Monoclonal ROCK1 Primary Antibody for WB - ABIN223244
Dasgupta, Argaiz, Mercado, Maul, Garza, Enriquez, Abdel-Monem, Prakasam, Andreeff, Thiagarajan: Platelet senescence and phosphatidylserine exposure. in Transfusion 2010
polarity-induced spatiotemporal control of Rok and Pkn (show PKN1 Antibodies) is important for unequal cortical expansion, ensuring correct cleavage furrow positioning and the establishment of physical asymmetry.
Loss of DRok function in tendon cells results in mis (show AMH Antibodies)-orientation of tendon cell extensions and abnormal accumulation of Thrombospondin and betaPS-integrin, which may cause abnormal myotendinous (show TNC Antibodies) junction formation and muscle morphogenesis.
model in which Rok-induced phosphorylation of residues within the basic region mediates the activation of FHOD1 (show FHOD1 Antibodies) homolog Knittrig in controlling macrophage migration
Atonal and EGFR (show EGFR Antibodies) signalling orchestrate rok- and Drak-dependent adherens junction remodelling during ommatidia morphogenesis.
The structure of Shrm (show SHROOM3 Antibodies) domain 2 (SD2), which mediates the interaction with Rock and is required for Shrm (show SHROOM3 Antibodies) function, is reported.
Data show that that Drak broadly promotes proper morphogenesis of epithelial tissues during development, and Drak activity is largely redundant with that of the Drosophila ROCK orthologue, Rok.
CD44 (show CD44 Antibodies) interaction with p115RhoGEF (show ARHGEF1 Antibodies) and ROK plays a pivotal role in promoting Gab-1 phosphorylation leading to Gab-1.PI 3 (show PI3 Antibodies)-kinase membrane localization, AKT (show AKT1 Antibodies) signaling, and cytokine (M-CSF (show CSF1R Antibodies)) production during HA-mediated breast cancer progression
Drok and Drosophila Lim (show ZYX Antibodies)-kinase interact in the developing nervous system
DRok is required for tissue morphogenesis in diverse compartments of the egg chamber during oogenesis
activation of RhoA/ROCK and PI3K/Akt plays a pivotal role in leptin signaling, leading to the development of VSMC hypertrophy through a mechanism involving altered actin dynamics
MicroRNA-146a suppresses ROCK1 allowing hyperphosphorylation of tau in Alzheimer's disease
Fasudil exhibited protective effects on smoke exposure induced cognitive deficits which might involve with the regulation of Rho/ROCK/NF-kappaB (show NFKB1 Antibodies) pathways.
we define how ROCK/LIMK (show LIMK1 Antibodies) pathway regulates mast cell development and functions
Dexamethasone up-regulates ROCK1/2 activity promoting migration, invasion and metastasis of melanoma cells.
mDia induces circumferential actin filaments around the edge of the synaptic cleft, which contract the presynaptic terminals in a ROCK-dependent manner.
SNRK (show SNRK Antibodies) in cardiomyocytes is responsible for maintaining cardiac metabolic homeostasis, which is mediated in part by ROCK, and alteration of this homeostasis influences cardiac function in the adult heart.
we uncovered cell state plasticity and adhesion dynamics regulated by Ror2 (show ROR2 Antibodies), which influenced Ras Homology Family Member A (show CXCL14 Antibodies) (RhoA (show RHOA Antibodies)) and Rho-Associated Coiled-Coil Kinase 1 (ROCK1) activity downstream of Dishevelled-2 (Dvl2 (show DVL2 Antibodies)).
Data indicate that oxidative stress in diabetes causes a decrease in miR (show MLXIP Antibodies)-133a expression leading to an increase in RhoA (show RHOA Antibodies)/Rho kinase (show ROCK2 Antibodies) pathway and muscle contraction.
that reduction of ROCK1 diminishes amyloid-beta levels by enhancing Amyloid beta-Protein Precursor protein degradation
ANXA1 (show ANXA1 Antibodies) restores Abeta42-induced blood brain barrier disruption through inhibition of RhoA (show RHOA Antibodies)-ROCK signaling pathway
Our findings revealed that ROCK1 was overexpressed in malignant vascular tumors such as hemangioendotheliomas and angiosarcomas, and ROCK2 (show ROCK2 Antibodies) was overexpressed in both benign and malignant vascular tumors including hemangiomas, hemangioendotheliomas, hemangiopericytomas, and angiosarcomas. shRNA-mediated knockdown of ROCK2 (show ROCK2 Antibodies), but not ROCK1, in xenograft vascular tumors significantly reduced tumor size and proliferative index
MicroRNA-146a suppresses ROCK1 allowing hyperphosphorylation of tau in Alzheimer's disease.
The migration of dermal endothelial cells undergoing epithelial-mesenchymal transition is dependent on both extracellular matrix degradation and invadosome formation associated with MMP-2 (show MMP2 Antibodies) proteolytic activity and Rho/ROCK cytoskeleton contraction.
ROCK inhibitor Y-27632 cooperated with Myc (show MYC Antibodies) to immortalize keratinocytes efficiently, indicating that apoptosis is a major barrier to Myc (show MYC Antibodies)-induced immortalization of keratinocytes.
Combined EGFR (show EGFR Antibodies) and ROCK inhibition effectively blocks proliferation of triple-negative breast cancer (TNBC) cells.
Inhibition of ROCK signaling restored polarity, decreased disorganization of F-actin, and led to reduction of proliferation of breast cancer cells.
Data show that ROCK1 is the direct target of miR (show MLXIP Antibodies)-300, and that the 3' UTRs of ROCK1 had at least 7 nucleotides that were complementary to the miR (show MLXIP Antibodies)-300 seed region.
ROCK activation phosphorylated Rac1b (show RAC3 Antibodies) at Ser71 and increased reactive oxygen species (ROS (show ROS1 Antibodies)) levels by facilitating the interaction between Rac1b (show RAC3 Antibodies) and cytochrome c (show CYCS Antibodies). Conversely, ROCK inactivation abolished their interaction, concomitant with ROS (show ROS1 Antibodies) reduction.
OB-Rb (show LEPR Antibodies), RhoA (show RHOA Antibodies)/ROCK, PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies), JAK (show JAK3 Antibodies)/STAT (show STAT1 Antibodies) pathways and NF-kB activation are involved in leptin (show LEP Antibodies)-induced upA (show PRAP1 Antibodies) expression.
Results indicate that ROCK1 and ROCK2 (show ROCK2 Antibodies) may exert different biological functions during the regulation of compaction and in ensuring development of porcine preimplantation embryos to the blastocyst stage.
It is highly possible that Rho-kinase plays an important role in the pathogenesis of in-stent restenosis. Rho-kinase is not involved in endothelial regeneration after vascular injury.
results suggest that the ROCK/MLC/actomyosin as well as ROCK/LIMK (show LIMK1 Antibodies)/cofilin (show CFL1 Antibodies) pathways regulate meiotic spindle migration and cytokinesis during bovine oocyte maturation.
In airway smooth muscle, muscle contraction involves the translocation of ROCK1 from non-caveolar to caveolar regions.
p38 (show MAPK14 Antibodies) phosphorylation and MMP13 (show MMP13 Antibodies) expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.
The RhoA (show RHOA Antibodies)/ROCK signaling pathway is an important negative regulator of vascular calcification.
caveolar and cholesterol integrity are indispensable for the proper functionality of the H(1) and 5-HT(2A) receptors through their Rho/ROCK signaling.
A functional contribution of PI3K, Rho, and ROCK to both the autocrine mechanism of ATP release and ATP-mediated angiogenic activation of vasa (show DDX4 Antibodies) vasorum endothelial cells, is reported.
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.
Rho-associated coiled coil containing protein kinase 1
, rho-associated protein kinase 1
, Rho-associated, coiled-coil containing protein kinase 1
, Rho-associated kinase
, RhoA kinase
, drosophila rho-associated kinase
, rho kinase
, Rho-associated coiled-coil forming kinase 1
, p160 ROCK-1
, rho-associated, coiled-coil-containing protein kinase 1
, rho-associated, coiled-coil-containing protein kinase I
, Rho-associated kinase beta
, liver regeneration-related protein LRRG199
, p150 RhoA-binding kinase ROK beta
, Rho kinase
, renal carcinoma antigen NY-REN-35
, cAMP-dependent protein kinase ROCK-I
, corneal epithelial Rho-associated-Ser/Thr kinase 1
, Rho-kinase beta
, Rho-associated protein kinase 1
, rho-associated coiled-coil domain-containing protein kinase 1