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Human TUBB Protein expressed in HEK-293 Cells - ABIN2734558
Chang, Zhao, Wang, Chen, Yan: Screening citrullinated proteins in synovial tissues of rheumatoid arthritis using 2-dimensional western blotting. in The Journal of rheumatology 2013
Leucine point mutations viz. L215H, L217R, and L225M were reported for paclitaxel resistance in various cancers. In the current study, molecular mechanism of these resistance causing mutations in TUBB1 (show TUBB1 Proteins) was explored using molecular docking, molecular dynamics simulation, binding energy estimation, free energy decomposition, principle component analysis and free energy landscape methods.
Data suggest a looser binding of the ligand in tubulin mutants.
Data show that tubulin phosphorylation and acetylation play important roles in the control of microtubule assembly and stability.
Data suggest that, while lacking a stable structure, NFL (show NEFL Proteins)-TBS.40-63 peptide (a peptide derived from light neurofilament protein (show NEFL Proteins)) preferentially binds on a specific single site located near C-terminal end of beta-tubulin.
Citrullination of TUBB (show TUBB2A Proteins) is associated with neoplasms.
mechanism of binding and stabilization of microtubules in mammalian cells can be effectively modeled in yeast and also having the advantage of lacking any beta-tubulin isotypes that can complicate interpretation of experiments in mammalian cells.
Data indicate that leucine-rich repeat kinase 2 (LRRK2 (show LRRK2 Proteins)) selectively interacts with three beta-tubulin isoforms: TUBB (show TUBB2A Proteins), TUBB4 (show TUBB3 Proteins), and TUBB6 (show TUBb6 Proteins).
Studies suggest that tubulin-interactive agents have the potential to play a significant role in the fight against cancer.
Centaurin-alpha (show ADAP1 Proteins) interacts with beta-tubulin and stabilizes microtubules.
results provide insight into the functional repertoire of the tubulin gene family, specifically implicating TUBB5 (show TUBB5 Proteins) in embryonic neurogenesis and microcephaly
The axial elastic modulus of tubulin diminishes as the length of the monomer increases.
The results suggest that betaTub97EF upregulation at low temperature contributes to acclimation by stabilizing microtubules.
The model of molecular folding for the mRNP particle involving the mRNA of beta-tubulin 56D has been proposed.
Our results indicate that the maternally supplied beta1-Tubulin based microtubule network is sufficient for myoblast fusion, myotube elongation and sarcomere formation both during visceral and somatic muscle development in Drosophila embryogenesis
Codepletion of Vhl (show VHL Proteins) with Mgr (show GRHL1 Proteins) gives partial rescue of tubulin instability, monopolar spindle formation, and loss of centrosomes.
Partially truncated beta2-tubulin (beta2Delta7) containing only the proximal portion of the C-terminal tail, including the axoneme motif, can support production of functional motile sperm.
beta2t plays an important role in salivary gland and myoblast migration
These data reveal that beta2-tubulin has robust properties for axoneme assembly, and that axonemal specializations are embedded in both the C-terminal tail and the body of the beta2 molecule.
Bagpipe (show NKX3-1 Proteins) and Biniou serve as direct, partially redundant, and tissue-specific activators of the terminal differentiation gene beta 3Tub60D in the visceral mesoderm
Study shows that homozygous TUBB5 knockin animals exhibit a severe reduction in brain size and in body weight. These animals do not show any significant impairment in general activity, anxiety, or in the acoustic startle response, however, present with notable defects in motor coordination.
This work sheds light on the functional repertoire of Tubb5, reveals that the E401K mutation acts by a complex mechanism, and demonstrates that the cellular pathology driving TUBB5-associated microcephaly is cell death.
Differentiation-mediated activation of JunD results in enhanced TUBB4a expression in P19 embryonal carcinoma cells.
TUBB5 is essential for neuronal differentiation and dendritic spine formation in vivo, providing insight into the underlying cellular pathology associated with TUBB5 disease states.
results provide insight into the functional repertoire of the tubulin gene family, specifically implicating TUBB5 in embryonic neurogenesis and microcephaly
Mutant huntingtin (show HTT Proteins) disrupts intracellular transport and insulin (show INS Proteins) secretion by interacting with tubulin beta 5.
beta 5-tubulin\; polymerizes to form microtubules\; member of a family of structural proteins
, beta Ib tubulin
, beta-4 tubulin
, class I beta-tubulin
, tubulin beta chain
, tubulin beta polypeptide
, tubulin beta-1 chain
, tubulin beta-5 chain
, tubulin, beta polypeptide
, putative cobalt-zinc-cadmium outer membrane resistance protein
, aarF domain containing kinase 5
, Tubulin, Beta family member (tbb-6)
, tubb beta-5
, tubulin beta-1
, tubulin, beta, 5
, tubulin, beta 2A
, tubulin, beta class I
, tubulin beta-2B chain
, tubulin, beta 2B class IIb
, tubulin beta
, tubulin beta5
, tubulin, beta 2
, tubulin, beta 2a
, tubulin, beta 4
, c(beta)7 tubulin
, tubulin beta 4'
, tubulin beta-7 chain
, tubulin, beta 2A class IIa
, beta tubulin
, beta-1 tubulin
, beta-Tubulin at 56 D
, beta-tubulin 56D
, beta1 tubulin
, tubulin beta1-chain
, 60C beta tubulin
, b-3 tubulin
, b3 tubulin
, beta 3 tubulin
, beta-3 tubulin
, beta-Tubulin at 60A
, beta-tubulin 60D
, beta3 tubulin
, tubulin b-3
, b2 tubulin
, beta 2 tubulin
, beta2 tubulin
, testis-specific beta-tubulin
, beta4 tubulin
, tubulin beta-4 chain
, tubulin beta-4A chain
, beta-5 tubulin
, beta-tubulin class-V
, tubulin, beta 5
, hypothetical protein
, tubulin beta-8 chain
, Class I beta-tubulin
, Tubulin beta-7 chain
, beta-tubulin isotype I
, class I beta tubulin