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General beta Actin Protein expressed in Escherichia coli (E. coli) - ABIN5662577
Cooke, Govender, Watson, Armstrong, ODwyer, Keane, King, Tynan, Dunn, Donnelly: Sarcoidosis, alveolar ?-actin and pulmonary fibrosis. in QJM : monthly journal of the Association of Physicians 2013
Human beta Actin Protein expressed in Wheat germ - ABIN1305739
Huang, Wang, Wang, Zhang, Deng, Wang, Zhang, Huang: Poly(ADP-ribose) polymerase 1 is indispensable for transforming growth factor-? Induced Smad3 activation in vascular smooth muscle cell. in PLoS ONE 2011
Baraitser-Winter cerebrofrontofacial syndrome is caused by missense mutations in the cytoplasmic beta- and gamma-actin (show ACTG1 Proteins) genes ACTB and ACTG1 (show ACTG1 Proteins). We provide an overview of the clinical characteristics (including some novel findings in four recently diagnosed patients), diagnosis, management, mutation spectrum and genetic counselling.
The authors describe heterozygous ACTB deletions and nonsense and frameshift mutations in 33 individuals with developmental delay, apparent intellectual disability, increased frequency of internal organ malformations (including those of the heart and the renal tract), growth retardation, and a recognizable facial gestalt.
Data indicate AIM1 (absent in melanoma 1) as an actin binding protein and show that it regulates cytoskeletal remodeling and cell migration in prostate epithelial cells.
Case Report: gastric pericytoma harboring the exceptionally rare translocation t(7;12) resulting in ACTB-GLI1 (show GLI1 Proteins) gene fusion.
Data suggest that, in T-lymphocytes, nitric oxide generated by eNOS (show NOS3 Proteins) S-nitrosylates Cys374 on ACTB and thus regulates activation/recruitment of PRKCQ (show PRKCQ Proteins) at immune synapse; S-nitrosylation of beta-actin impairs actin binding to PFN1 (show PFN1 Proteins) and regulates protein transport in lamellipodia. (eNOS (show NOS3 Proteins) = nitric oxide synthase 3; ACTB = beta-actin; PRKCQ (show PRKCQ Proteins) = protein kinase C-theta (show PRKCQ Proteins); PFN1 (show PFN1 Proteins) = profilin-1 (show PFN1 Proteins))
Data indicate that the IQGAP1 N-terminal fragment spanning residues 1-191 (CHDF) binds to both F-actin and Ca(2+)/calmodulin.
Based on present and published dup7p22.1 patients we suggest that renal abnormalities might be an additional feature of the 7p22.1 microduplication syndrome.We also pinpoint the ACTB gene as the key gene affecting the 7p22.1 duplication syndrome phenotype.
We suggest that haploinsufficiency of ACTB may be responsible for the clinical features of patients with 7p22.1 microdeletions
crucial role of Glu270 in ADP-ribosylation of actin by Ia
Studies indicate that the process of megakaryocyte maturation and the formation of proplatelets are essential steps in the production of mature platelets and both depend heavily on the actin and microtubule cytoskeletons.
These results suggest a a novel genome-wide mechanism where the polymerase-associated beta-actin synergizes with NM1 to coordinate permissive chromatin with Pol I transcription, cell growth, and proliferation.
Two actin isoforms, beta- and gamma-actin (show ACTG1 Proteins), are crucial for slow, rapid, bulk, and overshoot endocytosis at large calyx-type synapses, and for slow endocytosis and bulk endocytosis at small hippocampal synapses.
Melatonin treatment for 1 h increased monomeric actin and decreased polymeric actin.
Disruption of the in vivo interaction of KIF11 (show KIF11 Proteins) with ZBP1 (show ZBP1 Proteins) delocalizes beta-actin mRNA and affects cell migration.
TIA proteins can function as long-term regulators of the ACTB mRNA metabolism in mouse and human cells.
Actin binding proteins associated with stress fiber or focal adhesion formation are overexpressed in the beta-actin knock-out cells and many of these contain CH-, LIM (show PDLIM5 Proteins)- or EFh- domains.
Absence of beta-actin severely hampers formation of the peripheral nervous system, due to defective neural crest migration.
Data indicate that ectopic phosphatidylinositol 3,4,5-triphosphate (PIP3) elevation alone activated membranes to form actin-based structures whose behavior was similar to that of growth-cone-like "waves".
this work demonstrated that dendritic beta-actin messenger RNA and ribosomes are in a masked, neuron-specific form.
chorein interacts with beta-adducin (show ADD2 Proteins) and beta-actin.
These findings revise the existing spermiation model in Drosophila and suggest that somatic cells can actively oppose mechanical cell invasion attempts using calibrated F-actin dynamics in situ
Data suggest that the molecular and structural mechanism of actin polymerization by Spire should apply to other actin-binding proteins that contain WH2 domains in tandem.
actin filament subunits were directly modified by Mical on their conserved pointed-end, critical for filament assembly; Mical posttranslationally oxidized the methionine 44 residue within D-loop of actin, severing filaments and decreasing polymerization
essential cytoplasmic actin isoform
A mutational strategy is used to express monomeric 5C actin that is incapable of polymerization, able to bind skeletal myosin subfragment 1 and form a homogeneous complex, an ideal candidate for structural studies of actin complexes with motor proteins.
Taken together, these data can be explained by a model that associates components of the secretory machinery to the F-actin cortex through flexible links
biophysical analysis reveals that the open nucleotide pocket of the profilin (show PFN1 Proteins)/actin x-ray structure is unstable and closes in the absence of profilin (show PFN1 Proteins)
determination of the crystal structure of oxidized beta-actin to a resolution of 2.6 A; identification of oxidation of cysteine 272 in the crystallized actin dimer
The E2-interacting domain of beta-actin was mapped to amino acids (aa) 95-188 and two beta-actin-interacting regions were identified in E2 of classical swine fever virus (aa 182-261 and aa 262-341).
This study showed that beta-actin, L32 (show RPL32 Proteins) ribosomal protein, and ATP5B (show ATP5B Proteins) proteins were the most stabily expressed genes in cryopreserved horse semen.
HnRNP-R (show HNRNPR Proteins)-mediated axonal beta-actin mRNA translocation plays an essential physiological role for axon growth and presynaptic differentiation.
Data show that shortly after anaphase onset oocytes and embryonic cells exhibit cortical waves of Rho activity and F-actin polymerization.
This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins.
PS1TP5-binding protein 1
, actin, cytoplasmic 1
, beta cytoskeletal actin
, actin, alpha 1, skeletal muscle
, A-X actin-like protein
, actin, beta, cytoplasmic
, melanoma X-actin
, cytoplasmic beta-actin
, actin beta
, 5C actin
, actin 5 C
, actin 5C
, actin 5c
, actin A1
, cellular cytoskeletal beta-actin
, cytoplasmic 1
, cytoskeletal beta actin
, gamma non-muscle actin
, beta actin
, actin, beta