Browse our anti-RGS14 (RGS14) Antibodies

Human Regulator of G-Protein Signaling 14 (RGS14) interaction partners

1. The findings of this study suggested new pre- and postsynaptic regulatory functions of RGS14 and RGS14 variants, specific to the primate brain, and provide evidence for unconventional roles of RGS14 in the nuclei of striatal neuron.

2. Data support the notion that the Galpha, but not Gbetagamma, arm of the Gi/o signalling is involved in TRPC4 activation and unveil new roles for RGS and RGS14 in fine-tuning TRPC4 activities.

3. The RBD region associates with the RGS domain region, producing an intramolecular interaction within RGS14 that enhances the GTPase activating function.

4. RGS14 can form complexes with GPCRs in cells that are dependent on Galpha(i/o) and these RGS14.Galpha(i1).GPCR complexes may be substrates for other signaling partners such as Ric-8A

5. RGS-14 may facilitate cognitive processing by modulating Cav1 channel-mediated intracellular divalent calcium ion Ca(2)+ transients.

6. RGS14 serves as a novel scaffold to integrate GTP-Binding Protein alpha Subunit and Ras/Raf/MAPkinase signalling events through the action of its GL domain.

7. We show that RGS14 is a component of mitotic asters formed in vitro from HeLa cell extracts and that depletion of RGS14 from cell extracts blocks aster formation.

8. NMR 1H, 13C and 15N resonances of the RGS domain (residues 56-207)

Mouse (Murine) Regulator of G-Protein Signaling 14 (RGS14) interaction partners

1. The studies results demonstrate for the first time that RGS14 regulates plasticity in hippocampal area CA2 by restricting Ca(2+) elevations in CA2 spines and downstream signaling pathways.

2. Study shows that RGS14 mRNA and protein are upregulated throughout postnatal mouse development, and RGS14 protein exhibits a dynamic localization pattern that is enriched in hippocampus and primary olfactory cortex in the adult mouse brain

3. Inactive Galpha(i1)-GDP enhances the affinity of RGS14 for H-Ras-GTP in live cells, resulting in a ternary signaling complex that is further regulated by G protein-coupled receptors.

4. Activation of the Rsg14-Galphai1-GDP signaling complex is regulated by Ric8.

5. These results demonstrate that RGS14 is a key regulator of signaling pathways linking synaptic plasticity in CA2 pyramidal neurons to hippocampal-based learning and memory but distinct from the canonical DG-CA3-CA1 circuit.

6. the RGS14 GoLoco domain discriminates among Galphai isoforms

7. RGS14 is found ubiquitously throughout the postimplantation period in mice

8. RGS14 activity towards heterotrimeric G-proteins, as either a GAP or a guanine nucleotide dissociation inhibitor, was unaffected by Rap binding.

9. Morphine activation of Mu opioid receptors RGS14 prevents G-protein-coupled receptor kinases from phosphorylating those residues required for receptor endocytosis.

Zebrafish Regulator of G-Protein Signaling 14 (RGS14) interaction partners

1. The regulator of G-protein signaling 14a protein, regulates the temporal relations between the appearance of the guidance molecules and the acquisition of cellular motility by regulating E-cadherin levels.