RGS14 antibody

Catalog No. ABIN7118377

Product Details anti-RGS14 Antibody

Target: RGS14 (Regulator of G-Protein Signaling 14 (RGS14))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RGS14 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: regulator of G-protein signaling 14

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:200-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for RGS14

Target: RGS14 (Regulator of G-Protein Signaling 14 (RGS14))

Alternative Name: RGS14 (RGS14 Products)

Synonyms: RPIP1 antibody, MGC80558 antibody, RGS14 antibody, rgs14 antibody, wu:fi04g12 antibody, regulator of G protein signaling 14 antibody, regulator of G-protein signaling 14 antibody, regulator of G-protein signaling 14 L homeolog antibody, regulator of G-protein signalling 14 antibody, regulator of G protein signaling 14a antibody, RGS14 antibody, Rgs14 antibody, rgs14.L antibody, rgs14 antibody, rgs14a antibody

Background: Synonyms: Background:Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor(GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor(PDGF)-stimulated ERK1/ERK2 phosphorylation, a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor(NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory.

Molecular Weight: 60-65 kDa

Gene ID: 10636

UniProt: O43566

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Platelet-derived growth Factor Receptor Signaling