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Human Monoclonal Smooth Muscle Actin Primary Antibody for IHC (fro), IHC (p) - ABIN3044575
Li, Yao, Zhang, Bao, Chen, Wang, Yue, Li, Zhang, Hao: Genome-wide DNA methylation analysis in lung fibroblasts co-cultured with silica-exposed alveolar macrophages. in Respiratory research 2017
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Human Monoclonal Smooth Muscle Actin Primary Antibody for CyTOF, FACS - ABIN4900586
Delitto, Delitto, DiVita, Pham, Han, Hartlage, Newby, Gerber, Behrns, Moldawer, Thomas, George, Brusko, Mathews, Liu, Trevino, Hughes, Wallet: Human Pancreatic Cancer Cells Induce a MyD88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment. in Cancer research 2016
Show all 33 Pubmed References
Human Polyclonal Smooth Muscle Actin Primary Antibody for ICC, IF - ABIN4280053
Jeyasuria, Wetzel, Bradley, Subedi, Condon: Progesterone-regulated caspase 3 action in the mouse may play a role in uterine quiescence during pregnancy through fragmentation of uterine myocyte contractile proteins. in Biology of reproduction 2009
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Human Monoclonal Smooth Muscle Actin Primary Antibody for IEM, ICC - ABIN335372
Chaponnier, Goethals, Janmey, Gabbiani, Gabbiani, Vandekerckhove: The specific NH2-terminal sequence Ac-EEED of alpha-smooth muscle actin plays a role in polymerization in vitro and in vivo. in The Journal of cell biology 1995
Show all 14 Pubmed References
Human Polyclonal Smooth Muscle Actin Primary Antibody for ELISA, IHC - ABIN268804
Austin, Sens, Combs: Amyloid precursor protein mediates a tyrosine kinase-dependent activation response in endothelial cells. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
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Human Monoclonal Smooth Muscle Actin Primary Antibody for FACS - ABIN4897983
Asosingh, Aldred, Vasanji, Drazba, Sharp, Farver, Comhair, Xu, Licina, Huang, Anand-Apte, Yoder, Tuder, Erzurum: Circulating angiogenic precursors in idiopathic pulmonary arterial hypertension. in The American journal of pathology 2008
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Human Polyclonal Smooth Muscle Actin Primary Antibody for IHC, ELISA - ABIN185271
Reddy, Ozgur, Lu, Chang, Mohan, Kumar, Ruley: Structure of the human smooth muscle alpha-actin gene. Analysis of a cDNA and 5' upstream region. in The Journal of biological chemistry 1990
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Human Monoclonal Smooth Muscle Actin Primary Antibody for FACS - ABIN4897981
Morris, Khan, Ahmad, Weston, Nofchissey, Pinchuk, Beswick: G-CSF and G-CSFR are highly expressed in human gastric and colon cancers and promote carcinoma cell proliferation and migration. in British journal of cancer 2014
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Human Polyclonal Smooth Muscle Actin Primary Antibody for IHC, WB - ABIN1882764
Jay, Bielinska, Erlich, Mannisto, Pu, Heikinheimo, Wilson: Impaired mesenchymal cell function in Gata4 mutant mice leads to diaphragmatic hernias and primary lung defects. in Developmental biology 2007
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Human Monoclonal Smooth Muscle Actin Primary Antibody for IHC, ELISA - ABIN968946
Guo, Pannu, Tran-Fadulu, Papke, Yu, Avidan, Bourgeois, Estrera, Safi, Sparks, Amor, Ades, McConnell, Willoughby, Abuelo, Willing, Lewis, Kim, Scherer, Tung, Ahn, Buja, Raman, Shete, Milewicz: Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections. in Nature genetics 2007
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Data show that the locomotion and blebbing of the primordial germ cells (PGCs) required F-actin, myosin II activity and RhoA/Rho-associated protein kinase (ROCK) signaling.
cellular defects due to the ACTA2 mutation in both aortic smooth muscle cells and adventitial fibroblasts may contribute to development of thoracic aortic aneurysms and dissections and proliferative occlusive vascular disease
our results seemed to justify the conclusion that ACTA2 did not play a significant role in the pathogenesis of BAV aortopathy.
In patients with MYH11 (show MYH11 Antibodies) or ACTA2 variants, the effect of intronic variants on splicing was demonstrated on the mRNA level in the induced smooth muscle cell (SMC (show DYM Antibodies)), allowing classification into pathogenic or nonpathogenic variants.
We present a young woman whose ACTA2 mutation was ascertained during pregnancy because of her father's history of dissecting aneurysms. She was delivered at full term by cesarean section and subsequently had severe uterine hemorrhage due to uterine atony. Targeted analysis of the patient's ACTA2 gene revealed she had inherited the N117S variant from her father.
During transition from the pluripotent stage towards the neural developmental stage, ACTA2 is differentially expressed in bipolar patient derived cells compared to control derived cells.
Two unrelated patients with the heterozygous R189H mutation in ACTA2 and complex congenital heart defects expands the cardiac phenotype of multisystemic smooth muscle dysfunction syndrome.
Cells in high glucose for 7 days showed a significant decrease in mRNA expression of CD31 (show HBA1 Antibodies) and VE-cadherin (show CDH5 Antibodies), and a significant increase in that of alpha-SMA (show SMN1 Antibodies) and collagen I.
ACTA2 is the isoform of contractile protein (show TNNT2 Antibodies) alpha-actin present in vascular smooth muscle cells (SMCs) throughout the arterial tree.4 Pathologic conditions in individuals with ACTA2 mutations show increased deposition of SMCs in the intimal arterial layer, leading to a decreased intraluminal diameter.4
Two novel actin alpha 2 mutations (N117I and L348R) were identified in each familial non-syndromatic thoracic aortic aneurysm proband separately, and an additional novel actin alpha 2 mutation (Y168N) was identified in one patient with sporadic non-syndromatic thoracic aortic aneurysm.
The R179H mutation has the potential to affect actin structure and function in both the contractile domain of the cell and the more dynamic cytoskeletal pool of actin, both of which are required for contraction.
These data suggest that the interplay between cell-matrix adhesion and intercellular adhesion is an important determinant for some aspects of TGFbeta1 (show TGFB1 Antibodies)-induced epithelial-mesenchymal transition via alphaSMA expression induction.
The level of alpha-SMA (show SMN1 Antibodies) expression by intramuscular fibrogenic cells does not correlate positively with the level of collagen gene expression or the severity of skeletal muscle fibrosis in the mdx5cv mice. alpha-SMA (show SMN1 Antibodies) is not a functional marker of fibrogenic cells in skeletal muscle fibrosis associated with muscular dystrophy
Data suggest that membrane-proximal signaling complexes constrained by AKAP220 (show AKAP11 Antibodies) impact the actin barrier dynamics and AQP2 (show AQP2 Antibodies) trafficking to ensure water homeostasis.
Gremlin1 accelerates hepatic stellate cell activation through upregulation of TGF-B1, alpha-SMA (show SMN1 Antibodies), and COL1a1 (show COL1A1 Antibodies) expression in a liver fibrosis disease model.
Disruption of smooth muscle Acta2 increases reactive oxygen species levels, activates NF-kappaB (show NFKB1 Antibodies) signaling and increases AngII receptor type I a expression.
The expression levels of alpha-smooth muscle actin (show ACTG2 Antibodies) (alpha-SMA (show SMN1 Antibodies), a marker of fibroblast activation) in fibrotic livers were significantly higher than those in control livers.
this study identifies Rac1 as a downstream target for SMA (show SMN1 Antibodies) to inhibit smooth muscle cell proliferation and migration.
the coordinated up-regulations of desmin (show DES Antibodies) and alpha- actinin (show ACTN1 Antibodies) specifically in the early stage of diastolic heart failure mouse models indicate a novel myocardial response.
site-directed mutagenesis revealed several basic amino acid residues in the intermolecular (R267) and intramolecular (K82 (show KRT82 Antibodies) and R159) subdomains that are essential for Purbeta (show PURB Antibodies) transcriptional repressor function in Acta2 promoter-reporter assays. In keeping with their diminished Acta2 repressor activity in fibroblasts, purified Purbeta (show PURB Antibodies) variants containing an R267A mutation exhibited reduced binding affinity for purine-ric (show FXYD5 Antibodies)...
Alpha-smooth muscle actin (show ACTG2 Antibodies) protein (show ACTR3 Antibodies) and mRNA are enhanced from brain blood vessels in an Alzheimer's disease animal model.
TnT has a previously unrecognized role in forming the inactive state of regulated actin.
The terminal pointed end subunit is tilted (show OTOP1 Antibodies) towards the penultimate subunit, allowing specific and extra loop-to-loop inter-strand contacts between the two end subunits, which is not possible in other parts of the filament.
There was no significant change in the expression of TGF-beta(2 (show TGFB2 Antibodies)) and alpha-SMA (show SMN1 Antibodies) after laser-assisted intrastromal scanning.
The arrangement of actin subunits in an actin dimer assembled by tandem W domains resembles that of a long-pitch helix of the actin filament.
The distribution of laminin and alphaSMA in the testis and epididymis might point out to their roles in the male reproduction.
The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified.
, alpha smooth muscle actin
, actin, alpha 2, smooth muscle, aorta
, actin alpha cardiac 1
, actin, aortic smooth muscle
, vascular smooth muscle alpha-actin
, alpha-smooth muscle actin
, actin, aortic smooth muscle-like
, alpha-cardiac actin
, cell growth-inhibiting gene 46 protein
, actin, alpha, vascular smooth muscle
, alpha actin 2
, smooth muscle alpha-actin
, alpha actin