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anti-Human MUC1 Antibodies:
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Human Polyclonal MUC1 Primary Antibody for IHC (p) - ABIN3043421
Wang, Du, Wang, Kuang, Wang: Z-ligustilide attenuates lipopolysaccharide-induced proinflammatory response via inhibiting NF-kappaB pathway in primary rat microglia. in Acta pharmacologica Sinica 2010
Show all 19 Pubmed References
Human Monoclonal MUC1 Primary Antibody for ELISA, ICC - ABIN266893
Dalziel, Whitehouse, McFarlane, Brockhausen, Gschmeissner, Schwientek, Clausen, Burchell, Taylor-Papadimitriou: The relative activities of the C2GnT1 and ST3Gal-I glycosyltransferases determine O-glycan structure and expression of a tumor-associated epitope on MUC1. in The Journal of biological chemistry 2001
Show all 11 Pubmed References
Human Monoclonal MUC1 Primary Antibody for IHC (f), IHC (fro) - ABIN2689099
Agrawal, Schatz: RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination. in Cell 1997
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Human Monoclonal MUC1 Primary Antibody for ICC, FACS - ABIN335355
Gourevitch, von Mensdorff-Pouilly, Litvinov, Kenemans, van Kamp, Verstraeten, Hilgers: Polymorphic epithelial mucin (MUC-1)-containing circulating immune complexes in carcinoma patients. in British journal of cancer 1995
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Cow (Bovine) Polyclonal MUC1 Primary Antibody for ICC, IF - ABIN4336040
Rosa, Osorio, Trevisi, Yanqui-Rivera, Estill, Bionaz: 2,4-Thiazolidinedione Treatment Improves the Innate Immune Response in Dairy Goats with Induced Subclinical Mastitis. in PPAR research 2017
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Human Monoclonal MUC1 Primary Antibody for IHC (fro), IHC (p) - ABIN966067
Hilkens, Buijs, Hilgers, Hageman, Calafat, Sonnenberg, van der Valk: Monoclonal antibodies against human milk-fat globule membranes detecting differentiation antigens of the mammary gland and its tumors. in International journal of cancer. Journal international du cancer 1984
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Mouse (Murine) Polyclonal MUC1 Primary Antibody for IHC (fro), IHC (p) - ABIN3043886
Zhang, Chen, Shi, Xie, Liu, Zhang, Lai, Zuo, Chen, Liu, Wang: Establishment of a new representative model of human ovarian cancer in mice. in Journal of ovarian research 2013
Show all 2 Pubmed References
Human Monoclonal MUC1 Primary Antibody for IHC (fro), IHC (p) - ABIN3043642
Liu, Wei, Yang, Tan, Sun, Li, Che, Luan, Wang, Wang, Sun, Yin: Globose, cystic olfactory ensheathing cell tumor: A case report and literature review. in Oncology letters 2016
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A colon score derived from serum CEA, CA19-9, CK1 and MUC1 is a potential valuable non-invasive index that could be used for detection and screening early stage colon cancer patients
The suprachoroidal region of the eye comprises vascular channels, melanocytes, and thin fibroblasts with elongated cytoplasm that are positioned directly adjacent to the densely collagenous sclera. Granular, diffuse, and cytoplasmic EMA expression was seen in suprachoroidal fibroblasts, but this was not contiguous with the similar pattern of EMA expression in adjacent perineurium and arachnoid.
Calgranulin B and KL-6 in BAL proved to be reliable biomarkers of diopathic pulmonary fibrosis (IPF) and non-specific interstitial pneumonia (NSIP) and to have prognostic meaning, discriminating severe and advanced patients. The combination of the two biomarkers can facilitate the stratification of severity.
MUC1 is related to the occurrence and development of salivary gland acinic cell carcinoma
Baseline elevated serum KL-6 may predict deterioration of lung function of systemic sclerosis-interstitial lung disease patients with mild lung injury.
MUC1 expression is involved in accelerated growth of EMM1 cells.
These results suggest that certain proteins, such as MUC1, are selectively enriched in the exosome compartment. The mechanisms for their preferential localization and their biological roles remain to be studied
Through IL-11-STAT3/ERK signaling by upregulating MUC1.
this study shows that changes in serum KL-6 levels are associated with the development of chronic lung allograft dysfunction in lung transplant recipients
Interstitial lung disease patients with clubbing had lower oxygen levels, higher serum KL-6 levels, and lower pulmonary function than those without clubbing.
Mutated MUC1 (insC) affects vesicular transport in renal epithelial cells. It changes gene expression of vesicular transport-associated proteins, for example VTA1.
MUC1-C thereby contributes to the integration of PRC2 and PRC1-mediated repression of tumor suppressor genes, such as CDH1, CDKN2A, PTEN and BRCA1. Like PRC2 and PRC1, MUC1-C is associated with the epithelial-mesenchymal transition (EMT) program, cancer stem cell (CSC) state, and acquisition of anticancer drug resistance. [review]
MUC-1, CK7, and c-p27 immunostaining can be used as the predictive markers for esophageal cancer progression from Barrett's esophagus.
The CA 15-3 assay using 115D8-DF3 antibody pair is more suitable for monitoring therapy in pregnancy-associated breast cancer
MUC1-CT (cytoplasmic tail) expression was downregulated in lung tissue, bronchial epithelial cells and lung neutrophils from smokers and in COPD and it was correlated with their FEV1%
MiR-326 functioned as a tumor suppressor in PCa by negatively regulating MUC1.
To achieve this, using semi-quantitative mass spectrometry, we found MUC1 to be significantly and durably upregulated in response to erlotinib, an EGFR-targeting treatment. MUC1 upregulation was regulated transcriptionally, involving PI3K-signaling and STAT3
Studies demonstrate that MUC1-C-terminal beta subunit drives EZH2 expression in TNBC, NSCLC and other types of carcinoma cells. MUC1-C activates the EZH2 promoter through induction of the pRB-->E2F pathway. MUC1-C binds directly to the EZH2 CXC region adjacent to the catalytic SET domain and associates with EZH2 on the CDH1 and BRCA1 promoters.
Findings indicate that linc01296/miR-26a/GALNT3 axis involves in the progression of CRC cells, illuminating the possible mechanism mediated by O-glycosylated MUC1 via PI3K/AKT pathway.
The most strong relationship was registered between levels of expression of genes MUC I and IL32 (r-0.72; p=0.0001). In comparison with MUC I negative breast carcinoma, MUC I positive breast carcinoma characterized by higher level of mRNA of pro-inflammatory cytokines IL32 and capital IE, Cyrilliccapital TE, Cyrilliccapital A, Cyrillic
The results indicate that Muc1 gene is significantly associated with litter size in pigs.
Adhesion between Lactococcus lactis, the model for lactic acid bacteria (LAB) and mucins, is reported.
The epiblast expressed epithelial markers, MUC1 and E-CADHERIN, and the pluripotency markers, DNMT3B and CRIPTO.
Endometrial expressions of MUC1 and cytokine genes differed among normal, fertile versus diseased, and subfertile dairy cows.
Bovine Muc1 prevents binding of bacteria to human intestinal cells and may have a role in preventing the binding of common enteropathogenic bacteria to human intestinal epithelial surfaces.
concluded that bovine Muc1 protein is probably an inducible innate immune effector and an important component of the first line of defense against bacterial invasion of epithelial surfaces
Pseudomonas aeruginosa flagellin provokes NEU1-mediated airway shedding of MUC1-ectodomain, which functions as a decoy receptor protecting against lethal Pa lung infection.
The results showed that co-administration of an adjuvant plasmid and a DNA vaccine stimulated the production of higher titers of specific antibodies and a T cell response and suppressed the growth of subcutaneous tumors expressing MUC1.
these data showed that sustained abnormal MUC1 induction accompanies failing epithelial repair, chronic inflammation and kidney fibrosis. In conclusion, MUC1 exerts opposite effects during kidney response to IR: first protective and then harmful
MUC1 plays an important role in protection against severe pneumococcal disease, potentially mediated by facilitating macrophage phagocytosis.
this study implicates the MUC1 as a critical and dynamic component of the innate host response that limits the severity of influenza and provides the foundation for exploration of MUC1 in resolving inflammatory disease
Tumor growth delays observed by tumor irradiation combined with MVA-MUC1-IL-2 vaccine were significantly more prolonged than those observed by vaccine, radiation, or radiation with MVA empty vector.
Muc1 has anti-fibrotic properties in the mouse lung.
our data suggest a novel molecular mechanism by which tMUC1 may modulate NRP1-dependent VEGFR signaling in PDA cells.
Low expression of MUC1 is associated with lung carcinogenesis.
Using an extensive collection of novel murine cell lines we have identified distinct roles for Kras and Pten on MUC1 and EMT in vivo and in vitro. The data has implications for future design of combination therapies targeting Kras mutations, Pten deletions and MUC1 vaccines.
Gp91phox NADPH oxidase modulates litter size by up-regulating mucin1 expression in the uterus of mice.
In summary, we have demonstrated that MUC1 on immune cells is a novel regulator of the NLRP3 inflammasome, and propose this is mediated by an interaction with signalling components at the cytoplasmic domains of TLRs that involves inhibition of IRAK4 activation.
MUC1 regulates IL-1beta secretion induced by the NLRP3-activating bacteria Haemophilus influenzae but not bacteria that activate other inflammasomes.
Muc1 protection during acute kidney injury proceeds by enhancing both the HIF-1 and beta-catenin protective pathways.
MAMs MUC1 and MUC16 contribute to the maintenance of immune homeostasis at the ocular surface by limiting TLR-mediated innate immune responses.
the present study provides evidence that Muc1 is a direct target of let-7a and let-7b in mouse uteri during embryo implantation.
Anatomical site-specific Cre-loxP recombination throughout the genital tract of MUC1KrasPten mice leads to MUC1 positive genital tract tumors, and the development of these tumors is influenced by the anatomical environment
Muc1 clearly plays a significant role in enhancing the hypoxia-inducible transcription factors protective pathway during ischemic insult and recovery in kidney epithelia
Epithelial Muc1 is important for gastric mucosa healing by enhancing cell migration and proliferation.
the present study provides evidence that MUC1 is a direct target of miRNA-199a during embryo implantation.
This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.
, H23 antigen
, breast carcinoma-associated antigen DF3
, cancer antigen 15-3
, carcinoma-associated mucin
, krebs von den Lungen-6
, mucin 1, transmembrane
, peanut-reactive urinary mucin
, polymorphic epithelial mucin
, tumor associated epithelial mucin
, tumor-associated epithelial membrane antigen
, tumor-associated mucin
, endometrial mucin-1
, epithelial mucin