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MUC1 antibody (C-Term)

MUC1 Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Guinea Pig, Horse IHC, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2776819
  • Target See all MUC1 Antibodies
    MUC1 (Mucin 1 (MUC1))
    Binding Specificity
    • 26
    • 18
    • 16
    • 16
    • 12
    • 8
    • 7
    • 6
    • 6
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 271
    • 57
    • 29
    • 11
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Cow, Dog, Rabbit, Guinea Pig, Horse
    Host
    • 197
    • 87
    • 2
    • 1
    Rabbit
    Clonality
    • 175
    • 107
    • 5
    Polyclonal
    Conjugate
    • 146
    • 26
    • 16
    • 11
    • 11
    • 10
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This MUC1 antibody is un-conjugated
    Application
    • 140
    • 137
    • 102
    • 84
    • 75
    • 48
    • 26
    • 24
    • 24
    • 20
    • 19
    • 14
    • 13
    • 13
    • 6
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB)
    Sequence
    GQLDIFPARD TYHPMSEYPT YHTHGRYVPP SSTDRSPYEK VSAGNGGSSL
    Predicted Reactivity
    Cow: 92%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
    Characteristics
    This is a rabbit polyclonal antibody against MUC1. It was validated on Western Blot and immunohistochemistry.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human MUC1
    Top Product
    Discover our top product MUC1 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 203 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    MUC1 (Mucin 1 (MUC1))
    Alternative Name
    MUC1 (MUC1 Products)
    Synonyms
    CA 15-3 antibody, CD227 antibody, EMA antibody, H23AG antibody, KL-6 antibody, MAM6 antibody, MCKD1 antibody, MUC-1 antibody, MUC-1/SEC antibody, MUC-1/X antibody, MUC1/ZD antibody, PEM antibody, PEMT antibody, PUM antibody, Muc-1 antibody, mucin 1, cell surface associated antibody, mucin 1, transmembrane antibody, MUC1 antibody, Muc1 antibody
    Background
    MUC1 is a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas.
    Alias Symbols: CD227, EMA, PEM, PUM, mucin, KL-6, MAM6, PEMT, H23AG, MUC-1, MUC-1/X, MUC1/ZD, MUC-1/SEC
    Protein Interaction Partner: UBC, PPARG, IPO5, NUP62, EGFR, ABL1, SRC, JUN, TP53, TBP, IKBKG, TNFRSF1A, IKBKB, GRB2, ESR1, GALNT15, GALNT12, GALNT10, OSGEP, GSK3B, GALNT2, GALNT1, CTNND1, SIGLEC1, ERBB4, ERBB3, SOS1, PRKCD, ZAP70, APC, JUP, LYN, ERBB2, LCK, CTNNB1, GALNT4, BAX, CDKN1
    Protein Size: 203
    Molecular Weight
    22 kDa
    Gene ID
    4582
    NCBI Accession
    NM_001044390, NP_001037855
    UniProt
    Q7Z552
    Pathways
    Negative Regulation of intrinsic apoptotic Signaling
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